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Spatial fibroblast niches define Crohn's fistulae.

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Title: Spatial fibroblast niches define Crohn's fistulae.
Authors: McGregor C; Medical Research Council Translational Immune Discovery Unit (MRC TIDU), Weatherall Institute of Molecular Medicine (WIMM), University of Oxford, Oxford, UK.; Translational Gastroenterology and Liver Unit, John Radcliffe Hospital, Oxford, UK., Qin X; Medical Research Council Translational Immune Discovery Unit (MRC TIDU), Weatherall Institute of Molecular Medicine (WIMM), University of Oxford, Oxford, UK., Jagielowicz M; Medical Research Council Translational Immune Discovery Unit (MRC TIDU), Weatherall Institute of Molecular Medicine (WIMM), University of Oxford, Oxford, UK., Gupta T; Medical Research Council Translational Immune Discovery Unit (MRC TIDU), Weatherall Institute of Molecular Medicine (WIMM), University of Oxford, Oxford, UK.; Translational Gastroenterology and Liver Unit, John Radcliffe Hospital, Oxford, UK., Yin Z; Medical Research Council Translational Immune Discovery Unit (MRC TIDU), Weatherall Institute of Molecular Medicine (WIMM), University of Oxford, Oxford, UK., Lentsch V; Medical Research Council Translational Immune Discovery Unit (MRC TIDU), Weatherall Institute of Molecular Medicine (WIMM), University of Oxford, Oxford, UK., Fawkner-Corbett D; Medical Research Council Translational Immune Discovery Unit (MRC TIDU), Weatherall Institute of Molecular Medicine (WIMM), University of Oxford, Oxford, UK.; Academic Paediatric Surgery Unit, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Wien Lai V; Medical Research Council Translational Immune Discovery Unit (MRC TIDU), Weatherall Institute of Molecular Medicine (WIMM), University of Oxford, Oxford, UK.; MRC WIMM Centre for Computational Biology, WIMM, Oxford, UK., Gomez Castro P; Medical Research Council Translational Immune Discovery Unit (MRC TIDU), Weatherall Institute of Molecular Medicine (WIMM), University of Oxford, Oxford, UK., Bridges E; Medical Research Council Translational Immune Discovery Unit (MRC TIDU), Weatherall Institute of Molecular Medicine (WIMM), University of Oxford, Oxford, UK., Lee CH; Medical Research Council Translational Immune Discovery Unit (MRC TIDU), Weatherall Institute of Molecular Medicine (WIMM), University of Oxford, Oxford, UK.; MRC WIMM Centre for Computational Biology, WIMM, Oxford, UK., Chuang HW; Medical Research Council Translational Immune Discovery Unit (MRC TIDU), Weatherall Institute of Molecular Medicine (WIMM), University of Oxford, Oxford, UK., Deng L; Medical Research Council Translational Immune Discovery Unit (MRC TIDU), Weatherall Institute of Molecular Medicine (WIMM), University of Oxford, Oxford, UK., Aulicino A; Medical Research Council Translational Immune Discovery Unit (MRC TIDU), Weatherall Institute of Molecular Medicine (WIMM), University of Oxford, Oxford, UK., Teague R; Oxford Centre for Histopathological Research, Oxford University Hospitals NHS Trust, Oxford, UK., Moradi S; Oxford Centre for Histopathological Research, Oxford University Hospitals NHS Trust, Oxford, UK., Park JS; Medical Research Council Translational Immune Discovery Unit (MRC TIDU), Weatherall Institute of Molecular Medicine (WIMM), University of Oxford, Oxford, UK.; MRC WIMM Centre for Computational Biology, WIMM, Oxford, UK., Woo J; Medical Research Council Translational Immune Discovery Unit (MRC TIDU), Weatherall Institute of Molecular Medicine (WIMM), University of Oxford, Oxford, UK.; MRC WIMM Centre for Computational Biology, WIMM, Oxford, UK., Xu K; Medical Research Council Translational Immune Discovery Unit (MRC TIDU), Weatherall Institute of Molecular Medicine (WIMM), University of Oxford, Oxford, UK.; MRC WIMM Centre for Computational Biology, WIMM, Oxford, UK., Tandon R; Department of Cellular Pathology, Oxford University Hospitals NHS Trust, Oxford, UK., Cianci N; Center for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Bornschein J; Medical Research Council Translational Immune Discovery Unit (MRC TIDU), Weatherall Institute of Molecular Medicine (WIMM), University of Oxford, Oxford, UK.; Translational Gastroenterology and Liver Unit, John Radcliffe Hospital, Oxford, UK., Ho LP; Medical Research Council Translational Immune Discovery Unit (MRC TIDU), Weatherall Institute of Molecular Medicine (WIMM), University of Oxford, Oxford, UK., Siejka-Zielinska P; Medical Research Council Translational Immune Discovery Unit (MRC TIDU), Weatherall Institute of Molecular Medicine (WIMM), University of Oxford, Oxford, UK., Christoforidou Z; Medical Research Council Translational Immune Discovery Unit (MRC TIDU), Weatherall Institute of Molecular Medicine (WIMM), University of Oxford, Oxford, UK., Hill S; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Lehmann J; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Kujawa R; MRC WIMM Advanced Single Cell OMICS Facility, WIMM, Oxford, UK., Vargas Gutierrez P; MRC WIMM Advanced Single Cell OMICS Facility, WIMM, Oxford, UK., Cheng C; MRC WIMM Advanced Single Cell OMICS Facility, WIMM, Oxford, UK., Greco M; MRC WIMM Advanced Single Cell OMICS Facility, WIMM, Oxford, UK., Baker K; Department of Colorectal Surgery, Oxford University Hospitals NHS Trust, Oxford, UK., Bignell M; Department of Colorectal Surgery, Oxford University Hospitals NHS Trust, Oxford, UK., George B; Department of Colorectal Surgery, Oxford University Hospitals NHS Trust, Oxford, UK., Fryer E; Department of Cellular Pathology, Oxford University Hospitals NHS Trust, Oxford, UK., Vieth M; Institute of Pathology, Friedrich-Alexander University Erlangen-Nuremberg, Klinikum Bayreuth, Bayreuth, Germany., Antanaviciute A; Medical Research Council Translational Immune Discovery Unit (MRC TIDU), Weatherall Institute of Molecular Medicine (WIMM), University of Oxford, Oxford, UK. agne.antanaviciute@imm.ox.ac.uk.; MRC WIMM Centre for Computational Biology, WIMM, Oxford, UK. agne.antanaviciute@imm.ox.ac.uk., Simmons A; Medical Research Council Translational Immune Discovery Unit (MRC TIDU), Weatherall Institute of Molecular Medicine (WIMM), University of Oxford, Oxford, UK. alison.simmons@imm.ox.ac.uk.; Translational Gastroenterology and Liver Unit, John Radcliffe Hospital, Oxford, UK. alison.simmons@imm.ox.ac.uk.
Source: Nature [Nature] 2026 Jan; Vol. 649 (8097), pp. 703-712. Date of Electronic Publication: 2025 Nov 12.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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