Sacubitril-Valsartan for the Prevention of Anthracycline Cardiotoxicity in Patients With Elevated Cardiac Troponin I Concentration During Chemotherapy: A Double-Blind Randomized Placebo-Controlled Clinical Trial: The SARAH Trial.
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| Title: | Sacubitril-Valsartan for the Prevention of Anthracycline Cardiotoxicity in Patients With Elevated Cardiac Troponin I Concentration During Chemotherapy: A Double-Blind Randomized Placebo-Controlled Clinical Trial: The SARAH Trial. |
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| Authors: | Bonatto MG; Department of Cardiology, Division of Cardio-Oncology, Erasto Gaertner Hospital, Curitiba, Paraná, Brazil (M.G.B., L.D.L., N.R.A.d.C., T.B.R.M., J.M., T.T.O., L.C., L.A.M., S.C.).; Department of Cardiology, Division of Heart Failure, Santa Casa of Curitiba Hospital, Paraná, Brazil (M.G.B., A.d.O.C.).; Heart Failure Clinics, Instituto do Coração (Incor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Brazil (M.G.B., M.S.A., S.M.A.F., E.A.B.)., Avila MS; Heart Failure Clinics, Instituto do Coração (Incor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Brazil (M.G.B., M.S.A., S.M.A.F., E.A.B.)., Ayub Ferreira SM; Heart Failure Clinics, Instituto do Coração (Incor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Brazil (M.G.B., M.S.A., S.M.A.F., E.A.B.)., Lechinewski LD; Department of Cardiology, Division of Cardio-Oncology, Erasto Gaertner Hospital, Curitiba, Paraná, Brazil (M.G.B., L.D.L., N.R.A.d.C., T.B.R.M., J.M., T.T.O., L.C., L.A.M., S.C.)., Torres RA; Department of Cardiovascular Imaging, Institute of Neurology of Curitiba Hospital, Paraná, Brazil (R.d.A.T., A.d.N.C.)., Costa AN; Department of Cardiovascular Imaging, Institute of Neurology of Curitiba Hospital, Paraná, Brazil (R.d.A.T., A.d.N.C.)., Costa NRAD; Department of Cardiology, Division of Cardio-Oncology, Erasto Gaertner Hospital, Curitiba, Paraná, Brazil (M.G.B., L.D.L., N.R.A.d.C., T.B.R.M., J.M., T.T.O., L.C., L.A.M., S.C.)., Coiradas AO; Department of Cardiology, Division of Heart Failure, Santa Casa of Curitiba Hospital, Paraná, Brazil (M.G.B., A.d.O.C.)., Mialski TBR; Department of Cardiology, Division of Cardio-Oncology, Erasto Gaertner Hospital, Curitiba, Paraná, Brazil (M.G.B., L.D.L., N.R.A.d.C., T.B.R.M., J.M., T.T.O., L.C., L.A.M., S.C.)., Maiolino J; Department of Cardiology, Division of Cardio-Oncology, Erasto Gaertner Hospital, Curitiba, Paraná, Brazil (M.G.B., L.D.L., N.R.A.d.C., T.B.R.M., J.M., T.T.O., L.C., L.A.M., S.C.)., Ota TT; Department of Cardiology, Division of Cardio-Oncology, Erasto Gaertner Hospital, Curitiba, Paraná, Brazil (M.G.B., L.D.L., N.R.A.d.C., T.B.R.M., J.M., T.T.O., L.C., L.A.M., S.C.)., Contin L; Department of Cardiology, Division of Cardio-Oncology, Erasto Gaertner Hospital, Curitiba, Paraná, Brazil (M.G.B., L.D.L., N.R.A.d.C., T.B.R.M., J.M., T.T.O., L.C., L.A.M., S.C.)., Mosko LA; Department of Cardiology, Division of Cardio-Oncology, Erasto Gaertner Hospital, Curitiba, Paraná, Brazil (M.G.B., L.D.L., N.R.A.d.C., T.B.R.M., J.M., T.T.O., L.C., L.A.M., S.C.)., Bittencourt MS; Department of Medicine, Division of Cardiology, University of Pittsburgh, PA (M.S.B.)., Cauduro S; Department of Cardiology, Division of Cardio-Oncology, Erasto Gaertner Hospital, Curitiba, Paraná, Brazil (M.G.B., L.D.L., N.R.A.d.C., T.B.R.M., J.M., T.T.O., L.C., L.A.M., S.C.)., Zytynski Moura LA; Department of Medicine, Division of Cardiology, Pontifical Catholic University of Paraná, Curitiba, Paraná, Brazil (L.A.Z.M.)., Bocchi EA; Heart Failure Clinics, Instituto do Coração (Incor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Brazil (M.G.B., M.S.A., S.M.A.F., E.A.B.). |
| Source: | Circulation [Circulation] 2025 Dec 23; Vol. 152 (25), pp. 1742-1755. Date of Electronic Publication: 2025 Nov 13. |
| Publication Type: | Journal Article; Randomized Controlled Trial |
| Journal Info: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0147763 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4539 (Electronic) Linking ISSN: 00097322 NLM ISO Abbreviation: Circulation Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41230611 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Sacubitril-Valsartan for the Prevention of Anthracycline Cardiotoxicity in Patients With Elevated Cardiac Troponin I Concentration During Chemotherapy: A Double-Blind Randomized Placebo-Controlled Clinical Trial: The SARAH Trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Bonatto+MG%22">Bonatto MG</searchLink>; Department of Cardiology, Division of Cardio-Oncology, Erasto Gaertner Hospital, Curitiba, Paraná, Brazil (M.G.B., L.D.L., N.R.A.d.C., T.B.R.M., J.M., T.T.O., L.C., L.A.M., S.C.).; Department of Cardiology, Division of Heart Failure, Santa Casa of Curitiba Hospital, Paraná, Brazil (M.G.B., A.d.O.C.).; Heart Failure Clinics, Instituto do Coração (Incor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Brazil (M.G.B., M.S.A., S.M.A.F., E.A.B.).<br /><searchLink fieldCode="AU" term="%22Avila+MS%22">Avila MS</searchLink>; Heart Failure Clinics, Instituto do Coração (Incor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Brazil (M.G.B., M.S.A., S.M.A.F., E.A.B.).<br /><searchLink fieldCode="AU" term="%22Ayub+Ferreira+SM%22">Ayub Ferreira SM</searchLink>; Heart Failure Clinics, Instituto do Coração (Incor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Brazil (M.G.B., M.S.A., S.M.A.F., E.A.B.).<br /><searchLink fieldCode="AU" term="%22Lechinewski+LD%22">Lechinewski LD</searchLink>; Department of Cardiology, Division of Cardio-Oncology, Erasto Gaertner Hospital, Curitiba, Paraná, Brazil (M.G.B., L.D.L., N.R.A.d.C., T.B.R.M., J.M., T.T.O., L.C., L.A.M., S.C.).<br /><searchLink fieldCode="AU" term="%22Torres+RA%22">Torres RA</searchLink>; Department of Cardiovascular Imaging, Institute of Neurology of Curitiba Hospital, Paraná, Brazil (R.d.A.T., A.d.N.C.).<br /><searchLink fieldCode="AU" term="%22Costa+AN%22">Costa AN</searchLink>; Department of Cardiovascular Imaging, Institute of Neurology of Curitiba Hospital, Paraná, Brazil (R.d.A.T., A.d.N.C.).<br /><searchLink fieldCode="AU" term="%22Costa+NRAD%22">Costa NRAD</searchLink>; Department of Cardiology, Division of Cardio-Oncology, Erasto Gaertner Hospital, Curitiba, Paraná, Brazil (M.G.B., L.D.L., N.R.A.d.C., T.B.R.M., J.M., T.T.O., L.C., L.A.M., S.C.).<br /><searchLink fieldCode="AU" term="%22Coiradas+AO%22">Coiradas AO</searchLink>; Department of Cardiology, Division of Heart Failure, Santa Casa of Curitiba Hospital, Paraná, Brazil (M.G.B., A.d.O.C.).<br /><searchLink fieldCode="AU" term="%22Mialski+TBR%22">Mialski TBR</searchLink>; Department of Cardiology, Division of Cardio-Oncology, Erasto Gaertner Hospital, Curitiba, Paraná, Brazil (M.G.B., L.D.L., N.R.A.d.C., T.B.R.M., J.M., T.T.O., L.C., L.A.M., S.C.).<br /><searchLink fieldCode="AU" term="%22Maiolino+J%22">Maiolino J</searchLink>; Department of Cardiology, Division of Cardio-Oncology, Erasto Gaertner Hospital, Curitiba, Paraná, Brazil (M.G.B., L.D.L., N.R.A.d.C., T.B.R.M., J.M., T.T.O., L.C., L.A.M., S.C.).<br /><searchLink fieldCode="AU" term="%22Ota+TT%22">Ota TT</searchLink>; Department of Cardiology, Division of Cardio-Oncology, Erasto Gaertner Hospital, Curitiba, Paraná, Brazil (M.G.B., L.D.L., N.R.A.d.C., T.B.R.M., J.M., T.T.O., L.C., L.A.M., S.C.).<br /><searchLink fieldCode="AU" term="%22Contin+L%22">Contin L</searchLink>; Department of Cardiology, Division of Cardio-Oncology, Erasto Gaertner Hospital, Curitiba, Paraná, Brazil (M.G.B., L.D.L., N.R.A.d.C., T.B.R.M., J.M., T.T.O., L.C., L.A.M., S.C.).<br /><searchLink fieldCode="AU" term="%22Mosko+LA%22">Mosko LA</searchLink>; Department of Cardiology, Division of Cardio-Oncology, Erasto Gaertner Hospital, Curitiba, Paraná, Brazil (M.G.B., L.D.L., N.R.A.d.C., T.B.R.M., J.M., T.T.O., L.C., L.A.M., S.C.).<br /><searchLink fieldCode="AU" term="%22Bittencourt+MS%22">Bittencourt MS</searchLink>; Department of Medicine, Division of Cardiology, University of Pittsburgh, PA (M.S.B.).<br /><searchLink fieldCode="AU" term="%22Cauduro+S%22">Cauduro S</searchLink>; Department of Cardiology, Division of Cardio-Oncology, Erasto Gaertner Hospital, Curitiba, Paraná, Brazil (M.G.B., L.D.L., N.R.A.d.C., T.B.R.M., J.M., T.T.O., L.C., L.A.M., S.C.).<br /><searchLink fieldCode="AU" term="%22Zytynski+Moura+LA%22">Zytynski Moura LA</searchLink>; Department of Medicine, Division of Cardiology, Pontifical Catholic University of Paraná, Curitiba, Paraná, Brazil (L.A.Z.M.).<br /><searchLink fieldCode="AU" term="%22Bocchi+EA%22">Bocchi EA</searchLink>; Heart Failure Clinics, Instituto do Coração (Incor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Brazil (M.G.B., M.S.A., S.M.A.F., E.A.B.). – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%220147763%22">Circulation</searchLink> [Circulation] 2025 Dec 23; Vol. 152 (25), pp. 1742-1755. <i>Date of Electronic Publication: </i>2025 Nov 13. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Randomized Controlled Trial – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Lippincott+Williams+%26+Wilkins%22">Lippincott Williams & Wilkins </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0147763 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1524-4539 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200097322%22">00097322 </searchLink><i>NLM ISO Abbreviation: </i>Circulation <i>Subsets: </i>MEDLINE |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1161/CIRCULATIONAHA.125.073322 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 1742 Titles: – TitleFull: Sacubitril-Valsartan for the Prevention of Anthracycline Cardiotoxicity in Patients With Elevated Cardiac Troponin I Concentration During Chemotherapy: A Double-Blind Randomized Placebo-Controlled Clinical Trial: The SARAH Trial. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Bonatto MG – PersonEntity: Name: NameFull: Avila MS – PersonEntity: Name: NameFull: Ayub Ferreira SM – PersonEntity: Name: NameFull: Lechinewski LD – PersonEntity: Name: NameFull: Torres RA – PersonEntity: Name: NameFull: Costa AN – PersonEntity: Name: NameFull: Costa NRAD – PersonEntity: Name: NameFull: Coiradas AO – PersonEntity: Name: NameFull: Mialski TBR – PersonEntity: Name: NameFull: Maiolino J – PersonEntity: Name: NameFull: Ota TT – PersonEntity: Name: NameFull: Contin L – PersonEntity: Name: NameFull: Mosko LA – PersonEntity: Name: NameFull: Bittencourt MS – PersonEntity: Name: NameFull: Cauduro S – PersonEntity: Name: NameFull: Zytynski Moura LA – PersonEntity: Name: NameFull: Bocchi EA IsPartOfRelationships: – BibEntity: Dates: – D: 23 M: 12 Text: 2025 Dec 23 Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 1524-4539 Numbering: – Type: volume Value: 152 – Type: issue Value: 25 Titles: – TitleFull: Circulation Type: main |
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