TTP enhances the sensitivity of KRASG12C-mutated lung cancer cells to KRASG12C inhibitors by downregulating SLC7A11 and promoting ferroptosis.

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Title: TTP enhances the sensitivity of KRASG12C-mutated lung cancer cells to KRASG12C inhibitors by downregulating SLC7A11 and promoting ferroptosis.
Authors: Park KR; Department of Biological Sciences, University of Ulsan, Ulsan, South Korea., Le MX; Department of Biological Sciences, University of Ulsan, Ulsan, South Korea., Sul OJ; Basic-Clinic Convergence Research Institute, University of Ulsan, Ulsan, South Korea., Jeon J; Department of Biological Sciences, University of Ulsan, Ulsan, South Korea., Kwon MS; Department of Biological Sciences, University of Ulsan, Ulsan, South Korea., Lee H; Department of Biological Sciences, University of Ulsan, Ulsan, South Korea., Ra SW; Basic-Clinic Convergence Research Institute, University of Ulsan, Ulsan, South Korea; Department of Pulmonary and Critical Care Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea., Kwon HN; Department of Biological Sciences, University of Ulsan, Ulsan, South Korea; Basic-Clinic Convergence Research Institute, University of Ulsan, Ulsan, South Korea., Cho WJ; Department of Biological Sciences, University of Ulsan, Ulsan, South Korea. Electronic address: wjcho26@ulsan.ac.kr., Park JW; Department of Biological Sciences, University of Ulsan, Ulsan, South Korea; Basic-Clinic Convergence Research Institute, University of Ulsan, Ulsan, South Korea. Electronic address: jwpark@ulsan.ac.kr.
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2025 Dec; Vol. 193, pp. 118772. Date of Electronic Publication: 2025 Nov 15.
Publication Type: Journal Article
Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1950-6007
DOI:10.1016/j.biopha.2025.118772