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Comparative biophysical and functional analysis of TCZ-UFRJ, a potential biosimilar to Actemra.

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Title: Comparative biophysical and functional analysis of TCZ-UFRJ, a potential biosimilar to Actemra.
Authors: Corrêa Araújo S; School of Pharmacy, Pharmaceutical Biotechnology Dept., Universidade Federal do Rio de Janeiro - UFRJ, Brazil., Marsili FF; COPPE, Chemical Engineering Program, Cell Culture Engineering Lab, Universidade Federal do Rio de Janeiro - UFRJ, Brazil; Institute of Chemistry, Biochemistry Dept. Universidade Federal do Rio de Janeiro - UFRJ, Brazil., Guimarães Alvim R; COPPE, Chemical Engineering Program, Cell Culture Engineering Lab, Universidade Federal do Rio de Janeiro - UFRJ, Brazil., Dos Santos Cabral KM; Protein Advanced Biochemistry, National Center for Structural Biology and Bioimaging (CENABIO), Universidade Federal do Rio de Janeiro - UFRJ, Brazil., de Paula Neto HA; School of Pharmacy, Pharmaceutical Biotechnology Dept., Universidade Federal do Rio de Janeiro - UFRJ, Brazil., Cordeiro Y; School of Pharmacy, Pharmaceutical Biotechnology Dept., Universidade Federal do Rio de Janeiro - UFRJ, Brazil., da Silva Almeida M; Protein Advanced Biochemistry, National Center for Structural Biology and Bioimaging (CENABIO), Universidade Federal do Rio de Janeiro - UFRJ, Brazil., Dos Reis Castilho L; COPPE, Chemical Engineering Program, Cell Culture Engineering Lab, Universidade Federal do Rio de Janeiro - UFRJ, Brazil; Institute of Chemistry, Biochemistry Dept. Universidade Federal do Rio de Janeiro - UFRJ, Brazil., Sampaio Carvalho R; Institute of Biomedical Sciences. Universidade Federal do Rio de Janeiro - UFRJ, Brazil. Electronic address: renato.carvalho@icb.ufrj.br.
Source: Protein expression and purification [Protein Expr Purif] 2026 Mar; Vol. 239, pp. 106841. Date of Electronic Publication: 2025 Nov 11.
Publication Type: Journal Article; Comparative Study
Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 9101496 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0279 (Electronic) Linking ISSN: 10465928 NLM ISO Abbreviation: Protein Expr Purif Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Comparative biophysical and functional analysis of TCZ-UFRJ, a potential biosimilar to Actemra.
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  Data: <searchLink fieldCode="AU" term="%22Corrêa+Araújo+S%22">Corrêa Araújo S</searchLink>; School of Pharmacy, Pharmaceutical Biotechnology Dept., Universidade Federal do Rio de Janeiro - UFRJ, Brazil.<br /><searchLink fieldCode="AU" term="%22Marsili+FF%22">Marsili FF</searchLink>; COPPE, Chemical Engineering Program, Cell Culture Engineering Lab, Universidade Federal do Rio de Janeiro - UFRJ, Brazil; Institute of Chemistry, Biochemistry Dept. Universidade Federal do Rio de Janeiro - UFRJ, Brazil.<br /><searchLink fieldCode="AU" term="%22Guimarães+Alvim+R%22">Guimarães Alvim R</searchLink>; COPPE, Chemical Engineering Program, Cell Culture Engineering Lab, Universidade Federal do Rio de Janeiro - UFRJ, Brazil.<br /><searchLink fieldCode="AU" term="%22Dos+Santos+Cabral+KM%22">Dos Santos Cabral KM</searchLink>; Protein Advanced Biochemistry, National Center for Structural Biology and Bioimaging (CENABIO), Universidade Federal do Rio de Janeiro - UFRJ, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Paula+Neto+HA%22">de Paula Neto HA</searchLink>; School of Pharmacy, Pharmaceutical Biotechnology Dept., Universidade Federal do Rio de Janeiro - UFRJ, Brazil.<br /><searchLink fieldCode="AU" term="%22Cordeiro+Y%22">Cordeiro Y</searchLink>; School of Pharmacy, Pharmaceutical Biotechnology Dept., Universidade Federal do Rio de Janeiro - UFRJ, Brazil.<br /><searchLink fieldCode="AU" term="%22da+Silva+Almeida+M%22">da Silva Almeida M</searchLink>; Protein Advanced Biochemistry, National Center for Structural Biology and Bioimaging (CENABIO), Universidade Federal do Rio de Janeiro - UFRJ, Brazil.<br /><searchLink fieldCode="AU" term="%22Dos+Reis+Castilho+L%22">Dos Reis Castilho L</searchLink>; COPPE, Chemical Engineering Program, Cell Culture Engineering Lab, Universidade Federal do Rio de Janeiro - UFRJ, Brazil; Institute of Chemistry, Biochemistry Dept. Universidade Federal do Rio de Janeiro - UFRJ, Brazil.<br /><searchLink fieldCode="AU" term="%22Sampaio+Carvalho+R%22">Sampaio Carvalho R</searchLink>; Institute of Biomedical Sciences. Universidade Federal do Rio de Janeiro - UFRJ, Brazil. Electronic address: renato.carvalho@icb.ufrj.br.
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  Data: <searchLink fieldCode="JN" term="%229101496%22">Protein expression and purification</searchLink> [Protein Expr Purif] 2026 Mar; Vol. 239, pp. 106841. <i>Date of Electronic Publication: </i>2025 Nov 11.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Academic+Press%22">Academic Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9101496 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1096-0279 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210465928%22">10465928 </searchLink><i>NLM ISO Abbreviation: </i>Protein Expr Purif <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.pep.2025.106841
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      – Code: eng
        Text: English
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              Text: 2026 Mar
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