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Metformin for overweight and obese children and adolescents with bipolar spectrum and related mood disorders treated with second-generation antipsychotics: a randomised, pragmatic trial.

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Title: Metformin for overweight and obese children and adolescents with bipolar spectrum and related mood disorders treated with second-generation antipsychotics: a randomised, pragmatic trial.
Authors: DelBello MP; Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Electronic address: Delbelmp@ucmail.uc.edu., Welge JA; Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Klein CC; Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Blom TJ; Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Fornari V; Zucker Hillside Hospital/Northwell Health and Zucker School of Medicine at Hofstra/Northwell, Glen Oaks, NY, USA., Higdon C; Zucker Hillside Hospital/Northwell Health and Zucker School of Medicine at Hofstra/Northwell, Glen Oaks, NY, USA., Sorter MT; Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Kurtz B; Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Starr C; Cincinnati, OH, USA., Smith A; Depression and Bipolar Support Alliance, Chicago, IL, USA., Huang B; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Chen C; Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Modi AC; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Crimmins N; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Correll CU; Zucker Hillside Hospital/Northwell Health and Zucker School of Medicine at Hofstra/Northwell, Glen Oaks, NY, USA; Department of Psychiatry and Department of Child and Adolescent Psychiatry, Psychosomatic Medicine and Psychotherapy, Charité-Universitätsmedizin Berlin, Berlin, Germany; German Center for Mental Health, partner site Berlin, Berlin, Germany; German Center for Child and Adolescent Health, partner site Berlin, Berlin, Germany; Einstein Center for Population Diversity, Berlin, Germany.
Corporate Authors: MOBILITY Consortium
Source: The lancet. Psychiatry [Lancet Psychiatry] 2025 Dec; Vol. 12 (12), pp. 893-905.
Publication Type: Journal Article; Pragmatic Clinical Trial; Randomized Controlled Trial; Multicenter Study
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 101638123 Publication Model: Print Cited Medium: Internet ISSN: 2215-0374 (Electronic) Linking ISSN: 22150366 NLM ISO Abbreviation: Lancet Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Metformin for overweight and obese children and adolescents with bipolar spectrum and related mood disorders treated with second-generation antipsychotics: a randomised, pragmatic trial.
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  Data: <searchLink fieldCode="AU" term="%22DelBello+MP%22">DelBello MP</searchLink>; Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Electronic address: Delbelmp@ucmail.uc.edu.<br /><searchLink fieldCode="AU" term="%22Welge+JA%22">Welge JA</searchLink>; Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Klein+CC%22">Klein CC</searchLink>; Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Blom+TJ%22">Blom TJ</searchLink>; Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Fornari+V%22">Fornari V</searchLink>; Zucker Hillside Hospital/Northwell Health and Zucker School of Medicine at Hofstra/Northwell, Glen Oaks, NY, USA.<br /><searchLink fieldCode="AU" term="%22Higdon+C%22">Higdon C</searchLink>; Zucker Hillside Hospital/Northwell Health and Zucker School of Medicine at Hofstra/Northwell, Glen Oaks, NY, USA.<br /><searchLink fieldCode="AU" term="%22Sorter+MT%22">Sorter MT</searchLink>; Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Kurtz+B%22">Kurtz B</searchLink>; Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Starr+C%22">Starr C</searchLink>; Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Smith+A%22">Smith A</searchLink>; Depression and Bipolar Support Alliance, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Huang+B%22">Huang B</searchLink>; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Chen+C%22">Chen C</searchLink>; Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Modi+AC%22">Modi AC</searchLink>; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Crimmins+N%22">Crimmins N</searchLink>; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Correll+CU%22">Correll CU</searchLink>; Zucker Hillside Hospital/Northwell Health and Zucker School of Medicine at Hofstra/Northwell, Glen Oaks, NY, USA; Department of Psychiatry and Department of Child and Adolescent Psychiatry, Psychosomatic Medicine and Psychotherapy, Charité-Universitätsmedizin Berlin, Berlin, Germany; German Center for Mental Health, partner site Berlin, Berlin, Germany; German Center for Child and Adolescent Health, partner site Berlin, Berlin, Germany; Einstein Center for Population Diversity, Berlin, Germany.
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  Data: <searchLink fieldCode="JN" term="%22101638123%22">The lancet. Psychiatry</searchLink> [Lancet Psychiatry] 2025 Dec; Vol. 12 (12), pp. 893-905.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101638123 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>2215-0374 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2222150366%22">22150366 </searchLink><i>NLM ISO Abbreviation: </i>Lancet Psychiatry <i>Subsets: </i>MEDLINE
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        Value: 10.1016/S2215-0366(25)00273-1
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        Text: English
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              Text: 2025 Dec
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