Non-apoptotic caspase-8 is critical for orchestrating exaggerated inflammation during severe SARS-CoV-2 infection.
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| Title: | Non-apoptotic caspase-8 is critical for orchestrating exaggerated inflammation during severe SARS-CoV-2 infection. |
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| Authors: | M Bader S; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia. bader.s@wehi.edu.au.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia. bader.s@wehi.edu.au., Scherer L; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia., Bhandari R; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia., Motyer AJ; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia., Cooney JP; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia., Mackiewicz L; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia., Dayton M; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia., Sheerin D; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia., V L Romero D; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia., Schaefer J; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia., Pang J; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia., Chen S; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia.; College of Life Sciences, Nankai University, Tianjin, China., Schoffer K; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia., Wang L; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia., Jin X; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia., Batey D; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia., Yip RKH; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia., Zaman I; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia., Rajasekhar P; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia., Gartner MJ; Department of Microbiology and Immunology, the University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Wilcox S; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia., Whitehead L; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia., Georgy SR; Section of Anatomic Pathology, Melbourne Veterinary School, Faculty of Science, University of Melbourne, Werribee, Victoria, VIC, Australia., Maluenda A; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia., Davidson KC; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia., Allison CC; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia., Bowden R; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia., Brinkmann K; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia., Asselin-Labat ML; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia., Phipson B; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia., Tanzer MC; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia., Herold MJ; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia.; Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, VIC, Australia.; School of Cancer Medicine, La Trobe University, Heidelberg, Victoria, VIC, Australia., Samson AL; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia., Vince JE; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia., Strasser A; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia., Pellegrini M; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia. m.pellegrini@centenary.org.au.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia. m.pellegrini@centenary.org.au.; Centenary Institute and University of Technology Sydney, Faculty of Science, School of Life Sciences, Sydney, NSW, Australia. m.pellegrini@centenary.org.au., Doerflinger M; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia. doerflinger.m@wehi.edu.au.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia. doerflinger.m@wehi.edu.au. |
| Source: | Nature communications [Nat Commun] 2025 Nov 13; Vol. 16 (1), pp. 9822. Date of Electronic Publication: 2025 Nov 13. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41233351 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Non-apoptotic caspase-8 is critical for orchestrating exaggerated inflammation during severe SARS-CoV-2 infection. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22M+Bader+S%22">M Bader S</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia. bader.s@wehi.edu.au.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia. bader.s@wehi.edu.au.<br /><searchLink fieldCode="AU" term="%22Scherer+L%22">Scherer L</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Bhandari+R%22">Bhandari R</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Motyer+AJ%22">Motyer AJ</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Cooney+JP%22">Cooney JP</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Mackiewicz+L%22">Mackiewicz L</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Dayton+M%22">Dayton M</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Sheerin+D%22">Sheerin D</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22V+L+Romero+D%22">V L Romero D</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Schaefer+J%22">Schaefer J</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Pang+J%22">Pang J</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Chen+S%22">Chen S</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia.; College of Life Sciences, Nankai University, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Schoffer+K%22">Schoffer K</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Jin+X%22">Jin X</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Batey+D%22">Batey D</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Yip+RKH%22">Yip RKH</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Zaman+I%22">Zaman I</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Rajasekhar+P%22">Rajasekhar P</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Gartner+MJ%22">Gartner MJ</searchLink>; Department of Microbiology and Immunology, the University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Wilcox+S%22">Wilcox S</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Whitehead+L%22">Whitehead L</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Georgy+SR%22">Georgy SR</searchLink>; Section of Anatomic Pathology, Melbourne Veterinary School, Faculty of Science, University of Melbourne, Werribee, Victoria, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Maluenda+A%22">Maluenda A</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Davidson+KC%22">Davidson KC</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Allison+CC%22">Allison CC</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Bowden+R%22">Bowden R</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Brinkmann+K%22">Brinkmann K</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Asselin-Labat+ML%22">Asselin-Labat ML</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Phipson+B%22">Phipson B</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Tanzer+MC%22">Tanzer MC</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Herold+MJ%22">Herold MJ</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia.; Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, VIC, Australia.; School of Cancer Medicine, La Trobe University, Heidelberg, Victoria, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Samson+AL%22">Samson AL</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Vince+JE%22">Vince JE</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Strasser+A%22">Strasser A</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Pellegrini+M%22">Pellegrini M</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia. m.pellegrini@centenary.org.au.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia. m.pellegrini@centenary.org.au.; Centenary Institute and University of Technology Sydney, Faculty of Science, School of Life Sciences, Sydney, NSW, Australia. m.pellegrini@centenary.org.au.<br /><searchLink fieldCode="AU" term="%22Doerflinger+M%22">Doerflinger M</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, VIC, Australia. doerflinger.m@wehi.edu.au.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia. doerflinger.m@wehi.edu.au. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2025 Nov 13; Vol. 16 (1), pp. 9822. <i>Date of Electronic Publication: </i>2025 Nov 13. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101528555 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-1723 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220411723%22">20411723 </searchLink><i>NLM ISO Abbreviation: </i>Nat Commun <i>Subsets: </i>MEDLINE |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41467-025-65098-z Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 9822 Titles: – TitleFull: Non-apoptotic caspase-8 is critical for orchestrating exaggerated inflammation during severe SARS-CoV-2 infection. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: M Bader S – PersonEntity: Name: NameFull: Scherer L – PersonEntity: Name: NameFull: Bhandari R – PersonEntity: Name: NameFull: Motyer AJ – PersonEntity: Name: NameFull: Cooney JP – PersonEntity: Name: NameFull: Mackiewicz L – PersonEntity: Name: NameFull: Dayton M – PersonEntity: Name: NameFull: Sheerin D – PersonEntity: Name: NameFull: V L Romero D – PersonEntity: Name: NameFull: Schaefer J – PersonEntity: Name: NameFull: Pang J – PersonEntity: Name: NameFull: Chen S – PersonEntity: Name: NameFull: Schoffer K – PersonEntity: Name: NameFull: Wang L – PersonEntity: Name: NameFull: Jin X – PersonEntity: Name: NameFull: Batey D – PersonEntity: Name: NameFull: Yip RKH – PersonEntity: Name: NameFull: Zaman I – PersonEntity: Name: NameFull: Rajasekhar P – PersonEntity: Name: NameFull: Gartner MJ – PersonEntity: Name: NameFull: Wilcox S – PersonEntity: Name: NameFull: Whitehead L – PersonEntity: Name: NameFull: Georgy SR – PersonEntity: Name: NameFull: Maluenda A – PersonEntity: Name: NameFull: Davidson KC – PersonEntity: Name: NameFull: Allison CC – PersonEntity: Name: NameFull: Bowden R – PersonEntity: Name: NameFull: Brinkmann K – PersonEntity: Name: NameFull: Asselin-Labat ML – PersonEntity: Name: NameFull: Phipson B – PersonEntity: Name: NameFull: Tanzer MC – PersonEntity: Name: NameFull: Herold MJ – PersonEntity: Name: NameFull: Samson AL – PersonEntity: Name: NameFull: Vince JE – PersonEntity: Name: NameFull: Strasser A – PersonEntity: Name: NameFull: Pellegrini M – PersonEntity: Name: NameFull: Doerflinger M IsPartOfRelationships: – BibEntity: Dates: – D: 13 M: 11 Text: 2025 Nov 13 Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 2041-1723 Numbering: – Type: volume Value: 16 – Type: issue Value: 1 Titles: – TitleFull: Nature communications Type: main |
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