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Development and Validation of a Type 1 Diabetes Multi-Ancestry Polygenic Score.

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Title: Development and Validation of a Type 1 Diabetes Multi-Ancestry Polygenic Score.
Authors: Deutsch AJ; Diabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA.; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA.; Department of Medicine, Harvard Medical School, Boston, MA., Bell AS; Department of Medicine, Harvard Medical School, Boston, MA., Michalek DA; Department of Genome Sciences, University of Virginia, Charlottesville, VA., Burkholder AB; Office of Environmental Science Cyberinfrastructure, National Institute of Environmental Health Sciences, Durham, NC., Nam S; Diabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA.; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA., Kreienkamp RJ; Diabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA.; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA.; Department of Medicine, Harvard Medical School, Boston, MA.; Division of Endocrinology, Department of Pediatrics, Boston Children's Hospital, Boston, MA., Sharp SA; Diabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA.; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA., Huerta-Chagoya A; Diabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA.; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA., Mandla R; Diabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA.; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA.; Graduate Program in Genomics and Computational Biology, University of Pennsylvania, Philadelphia, PA.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Nanjala R; Kennedy Institute of Rheumatology, University of Oxford, Oxford, U.K., Luo Y; Kennedy Institute of Rheumatology, University of Oxford, Oxford, U.K., Oram RA; College of Medicine and Health, University of Exeter, Exeter, U.K.; Royal Devon University Healthcare National Health Service Foundation Trust, Exeter, U.K., Florez JC; Diabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA.; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA.; Department of Medicine, Harvard Medical School, Boston, MA., Onengut-Gumuscu S; Department of Genome Sciences, University of Virginia, Charlottesville, VA., Rich SS; Department of Genome Sciences, University of Virginia, Charlottesville, VA., Ng MCY; Vanderbilt Genetics Institute and Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN., Motsinger-Reif AA; Biostatistics & Computational Biology Branch, National Institute of Environmental Health Sciences, Durham, NC., Manning AK; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA.; Department of Medicine, Harvard Medical School, Boston, MA.; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA., Mercader JM; Diabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA.; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA.; Department of Medicine, Harvard Medical School, Boston, MA., Udler MS; Diabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA.; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA.; Department of Medicine, Harvard Medical School, Boston, MA.
Source: Diabetes [Diabetes] 2026 Jan 01; Vol. 75 (1), pp. 205-214.
Publication Type: Journal Article; Validation Study
Journal Info: Publisher: American Diabetes Association Country of Publication: United States NLM ID: 0372763 Publication Model: Print Cited Medium: Internet ISSN: 1939-327X (Electronic) Linking ISSN: 00121797 NLM ISO Abbreviation: Diabetes Subsets: MEDLINE
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Department of Genome Sciences, University of Virginia, Charlottesville, VA.<br /><searchLink fieldCode="AU" term="%22Ng+MCY%22">Ng MCY</searchLink>; Vanderbilt Genetics Institute and Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN.<br /><searchLink fieldCode="AU" term="%22Motsinger-Reif+AA%22">Motsinger-Reif AA</searchLink>; Biostatistics & Computational Biology Branch, National Institute of Environmental Health Sciences, Durham, NC.<br /><searchLink fieldCode="AU" term="%22Manning+AK%22">Manning AK</searchLink>; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA.; Department of Medicine, Harvard Medical School, Boston, MA.; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Mercader+JM%22">Mercader JM</searchLink>; Diabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA.; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA.; Department of Medicine, Harvard Medical School, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Udler+MS%22">Udler MS</searchLink>; Diabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA.; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA.; Department of Medicine, Harvard Medical School, Boston, MA.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Diabetes+Association%22">American Diabetes Association </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0372763 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1939-327X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200121797%22">00121797 </searchLink><i>NLM ISO Abbreviation: </i>Diabetes <i>Subsets: </i>MEDLINE
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        Value: 10.2337/db25-0772
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