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Neurodevelopmental disorder-linked Argonaute mutations permit delayed RISC formation and unusual shortening of miRNAs by 3'→5' trimming.

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Title: Neurodevelopmental disorder-linked Argonaute mutations permit delayed RISC formation and unusual shortening of miRNAs by 3'→5' trimming.
Authors: Savidge A; Ohio State Biochemistry Program, The Ohio State University, Columbus, OH 43210.; Center for RNA Biology, The Ohio State University, Columbus, OH 43210.; Cellular, Molecular and Biochemical Sciences Program, The Ohio State University, Columbus, OH 43210., Zhang H; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210., Annasaheb Adhav V; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210., Kehling AC; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210., Sim G; Center for RNA Biology, The Ohio State University, Columbus, OH 43210.; Molecular, Cellular and Developmental Biology, The Ohio State University, Columbus, OH 43210., Shen Z; Department of Biological Chemistry and Pharmacology, The Ohio State University, Columbus, OH 43210., Fu TM; Ohio State Biochemistry Program, The Ohio State University, Columbus, OH 43210.; Center for RNA Biology, The Ohio State University, Columbus, OH 43210.; Department of Biological Chemistry and Pharmacology, The Ohio State University, Columbus, OH 43210.; The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210.; Department of Pathology, University of Massachusetts Chan Medical School, Worcester, MA 01605., Nakanishi K; Ohio State Biochemistry Program, The Ohio State University, Columbus, OH 43210.; Center for RNA Biology, The Ohio State University, Columbus, OH 43210.; Cellular, Molecular and Biochemical Sciences Program, The Ohio State University, Columbus, OH 43210.; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210.; Molecular, Cellular and Developmental Biology, The Ohio State University, Columbus, OH 43210.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Nov 18; Vol. 122 (46), pp. e2524644122. Date of Electronic Publication: 2025 Nov 14.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: Neurodevelopmental disorder-linked Argonaute mutations permit delayed RISC formation and unusual shortening of miRNAs by 3'→5' trimming.
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  Data: <searchLink fieldCode="AU" term="%22Savidge+A%22">Savidge A</searchLink>; Ohio State Biochemistry Program, The Ohio State University, Columbus, OH 43210.; Center for RNA Biology, The Ohio State University, Columbus, OH 43210.; Cellular, Molecular and Biochemical Sciences Program, The Ohio State University, Columbus, OH 43210.<br /><searchLink fieldCode="AU" term="%22Zhang+H%22">Zhang H</searchLink>; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210.<br /><searchLink fieldCode="AU" term="%22Annasaheb+Adhav+V%22">Annasaheb Adhav V</searchLink>; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210.<br /><searchLink fieldCode="AU" term="%22Kehling+AC%22">Kehling AC</searchLink>; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210.<br /><searchLink fieldCode="AU" term="%22Sim+G%22">Sim G</searchLink>; Center for RNA Biology, The Ohio State University, Columbus, OH 43210.; Molecular, Cellular and Developmental Biology, The Ohio State University, Columbus, OH 43210.<br /><searchLink fieldCode="AU" term="%22Shen+Z%22">Shen Z</searchLink>; Department of Biological Chemistry and Pharmacology, The Ohio State University, Columbus, OH 43210.<br /><searchLink fieldCode="AU" term="%22Fu+TM%22">Fu TM</searchLink>; Ohio State Biochemistry Program, The Ohio State University, Columbus, OH 43210.; Center for RNA Biology, The Ohio State University, Columbus, OH 43210.; Department of Biological Chemistry and Pharmacology, The Ohio State University, Columbus, OH 43210.; The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210.; Department of Pathology, University of Massachusetts Chan Medical School, Worcester, MA 01605.<br /><searchLink fieldCode="AU" term="%22Nakanishi+K%22">Nakanishi K</searchLink>; Ohio State Biochemistry Program, The Ohio State University, Columbus, OH 43210.; Center for RNA Biology, The Ohio State University, Columbus, OH 43210.; Cellular, Molecular and Biochemical Sciences Program, The Ohio State University, Columbus, OH 43210.; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210.; Molecular, Cellular and Developmental Biology, The Ohio State University, Columbus, OH 43210.
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  Data: <searchLink fieldCode="JN" term="%227505876%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink> [Proc Natl Acad Sci U S A] 2025 Nov 18; Vol. 122 (46), pp. e2524644122. <i>Date of Electronic Publication: </i>2025 Nov 14.
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              Text: 2025 Nov 18
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