The structure, redox chemistry and motor neuron toxicity of heterodimeric zinc-deficient SOD1-implications for the toxic gain of function observed in ALS.
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| Title: | The structure, redox chemistry and motor neuron toxicity of heterodimeric zinc-deficient SOD1-implications for the toxic gain of function observed in ALS. |
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| Authors: | Streltsov VA; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC 3010, Australia; CSIRO, Manufacturing Division, 343 Royal Parade, Parkville, Victoria 3052, Australia. Electronic address: victor.streltsov@florey.edu.au., Ganio KE; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC 3010, Australia., Nuttall SD; CSIRO, Manufacturing Division, 343 Royal Parade, Parkville, Victoria 3052, Australia., Hernandez JA; Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32827, United States of America., Dennys CN; Alcyone Therapeutics, 116 John Street, Suite 300, Lowell, MA, United States of America., Crouch PJ; Department of Biochemistry and Pharmacology, The University of Melbourne, Parkville, VIC 3010, Australia., Estevez AG; Center for Translational Science, Florida International University, Port St. Lucie, FL 34987, USA; Departement of Cellular & Molecular Medicine, Herbert Wertheim College of Medicine, Florida International University, Port St. Lucie, FL 34987, USA., Franco MC; Center for Translational Science, Florida International University, Port St. Lucie, FL 34987, USA; Departement of Cellular & Molecular Medicine, Herbert Wertheim College of Medicine, Florida International University, Port St. Lucie, FL 34987, USA., Beckman JS; Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR 97331, USA; Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA. Electronic address: joe.beckman@oregonstate.edu., Roberts BR; Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA. Electronic address: blaine.roberts@emory.edu. |
| Source: | Neurobiology of disease [Neurobiol Dis] 2025 Dec; Vol. 217, pp. 107189. Date of Electronic Publication: 2025 Nov 12. |
| Publication Type: | Journal Article; Research Support, N.I.H., Intramural |
| Journal Info: | Publisher: Academic Press Country of Publication: United States NLM ID: 9500169 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-953X (Electronic) Linking ISSN: 09699961 NLM ISO Abbreviation: Neurobiol Dis Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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