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Automated reporting of primaquine dose efficacy, tolerability and safety for Plasmodium vivax malaria using a systematic review and individual patient data meta-analysis.

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Title: Automated reporting of primaquine dose efficacy, tolerability and safety for Plasmodium vivax malaria using a systematic review and individual patient data meta-analysis.
Authors: Edler P; Department of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Rajasekhar M; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia., Price DJ; Department of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia., Adam I; Department of Obstetrics and Gynecology, College of Medicine, Qassim University, Buraidah, Saudi Arabia., Awab GR; Mahidol Oxford Tropical Medicine Research Unit (MORU), Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Department of Public and Global Health, Afghan International Islamic University, Kabul, Afghanistan., Barber BE; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia.; Infectious Diseases Society Sabah-Menzies School of Health Research Clinical Research Unit, Kota Kinabalu, Sabah, Malaysia., Brasil LW; Diretoria de Ensino e Pesquisa, Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Amazonas, Brazil.; Programa de Pós‑Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus, Amazonas, Brazil., Chamma-Siqueira NN; Laboratório de Malária, Instituto Evandro Chagas, Ministério da Saúde do Brasil, Ananindeua, Pará State, Brazil., Chu CS; Shoklo Malaria Research Unit, Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., Cui L; Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA., Daher A; Fiocruz Clinical Research Platform, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil.; Vice‑Presidency of Research and Biological Collections, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil., Gomes MDSM; Superintendência de Vigilância em Saúde do Estado do Amapá - SVS/AP, Macapá, Amapá, Brazil.; Federal University of aMAPA, Universidade Federal do Amapá - UNIFAP), Macapá, Amapá, Brazil., Gonzalez-Ceron L; Regional Centre for Public Health Research, National Institute for Public Health, Tapachula, Chiapas, Mexico., Grigg MJ; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia.; Infectious Diseases Society Sabah-Menzies School of Health Research Clinical Research Unit, Kota Kinabalu, Sabah, Malaysia., Karunajeewa H; Department of Medicine-Western Health, Melbourne Medical School, The University of Melbourne, St. Albans, VIC, Australia., Lacerda MVG; Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Brazil.; Instituto Leônidas E Maria Deane, Fiocruz, Manaus, Brazil.; University of Texas Medical Branch, Galveston, USA., Ladeia-Andrade S; Laboratory of Parasitic Diseases, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Brazil.; Institute of Hygiene and Tropical Medicine, Global Health and Tropical Medicine, NOVA University of Lisbon, Lisbon, Portugal., Leslie T; Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK.; HealthNet-TPO, Kabul, Afghanistan., Ley B; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia., Lidia K; The Department of Pharmacology and Therapy, Faculty of Medicine and Veterinary Medicine, Universitas Nusa Cendana, Kupang, Indonesia., Llanos-Cuentas A; Unit of Leishmaniasis and Malaria, Instituto de Medicina Tropical 'Alexander Von Humboldt', Universidad Peruana Cayetano Heredia, Lima, Peru., Longley RJ; Mahidol Vivax Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Infection and Global Health Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Australia., Manning L; Medical School, University of Western Australia, Crawley, Australia.; Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, Perth, Australia.; Department of Infectious Diseases, Fiona Stanley Hospital, Perth, Australia., Mekonnen DA; Malaria and Neglected Tropical Diseases Directorate, Armauer Hansen Research Institute, Addis Ababa, Ethiopia.; Haramaya University, Dire Dawa, Ethiopia., Monteiro WM; Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Brazil.; Universidade do Estado do Amazonas, Manaus, Brazil., Moore BR; Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, Perth, Australia.; Curtin Medical School, Faculty of Health Science, Curtin University, Perth, Australia.; Curtin Medical Research Institute, Curtin University, Perth, Australia., Nosten F; Shoklo Malaria Research Unit, Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., Pasaribu AP; Department of Pediatrics, Medical Faculty, Universitas Sumatera Utara, Medan, North Sumatera, Indonesia., Pereira DB; Centro de Pesquisa Em Medicina Tropical de Rondonia (CEPEM), Porto Velho, Brazil.; Fundação Universidade Federal de Rondonia (UNIR), Porto Velho, Brazil., Poespoprodjo JR; Mimika District Hospital, Timika, Indonesia.; Timika Malaria Research Programme, Papuan Health and Community Development Foundation, Timika, Indonesia.; Paediatric Research Office, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia., Pukrittayakamee S; Mahidol Oxford Tropical Medicine Research Unit (MORU), Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand., Rijal KR; Central Department of Microbiology, Tribhuvan University, Kirtipur, Nepal.; Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand., Saravu K; Department of Infectious Diseases, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, Madhava Nagar, Manipal, Karnataka, India., Siqueira AM; Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, Brazil., Sutanto I; Department of Parasitology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia., Taylor WRJ; Mahidol Oxford Tropical Medicine Research Unit (MORU), Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., Thanh PV; Parasitology and Entomology, National Institute of Malariology, Hanoi, Vietnam., Thriemer K; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia., Vieira JLF; Federal University of Pará (Universidade Federal Do Pará - UFPA), Belém, Pará, Brazil., White NJ; Mahidol Oxford Tropical Medicine Research Unit (MORU), Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., Yeshiwondim AK; World Health Organization Country Office for Addis Ababa, Addis Ababa, Ethiopia., Zuluaga-Idarraga LM; Grupo Malaria, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.; Facultad Nacional de Salud Publica, Universidad de Antioquia, Medellín, Colombia., Guerin PJ; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.; WorldWide Antimalarial Resistance Network (WWARN), Oxford, UK.; Infectious Diseases Data Observatory (IDDO), Oxford, UK., Simpson JA; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.; WorldWide Antimalarial Resistance Network (WWARN), Asia-Pacific Regional Centre, Melbourne, Australia., Price RN; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia.; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.; WorldWide Antimalarial Resistance Network (WWARN), Asia-Pacific Regional Centre, Melbourne, Australia., Commons RJ; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia. rob.commons@wwarn.org.; WorldWide Antimalarial Resistance Network (WWARN), Asia-Pacific Regional Centre, Melbourne, Australia. rob.commons@wwarn.org.; General and Subspecialty Medicine, Grampians Health-Ballarat, Ballarat, Australia. rob.commons@wwarn.org.
Corporate Authors: WorldWide Antimalarial Resistance Network (WWARN) Vivax Primaquine Dosing Efficacy, Tolerability and Safety Study Group
Source: Malaria journal [Malar J] 2025 Nov 14; Vol. 24 (1), pp. 400. Date of Electronic Publication: 2025 Nov 14.
Publication Type: Journal Article; Systematic Review; Meta-Analysis
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101139802 Publication Model: Electronic Cited Medium: Internet ISSN: 1475-2875 (Electronic) Linking ISSN: 14752875 NLM ISO Abbreviation: Malar J Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Automated reporting of primaquine dose efficacy, tolerability and safety for Plasmodium vivax malaria using a systematic review and individual patient data meta-analysis.
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Mahidol Oxford Tropical Medicine Research Unit (MORU), Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Department of Public and Global Health, Afghan International Islamic University, Kabul, Afghanistan.<br /><searchLink fieldCode="AU" term="%22Barber+BE%22">Barber BE</searchLink>; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia.; Infectious Diseases Society Sabah-Menzies School of Health Research Clinical Research Unit, Kota Kinabalu, Sabah, Malaysia.<br /><searchLink fieldCode="AU" term="%22Brasil+LW%22">Brasil LW</searchLink>; Diretoria de Ensino e Pesquisa, Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Amazonas, Brazil.; Programa de Pós‑Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus, Amazonas, Brazil.<br /><searchLink fieldCode="AU" term="%22Chamma-Siqueira+NN%22">Chamma-Siqueira NN</searchLink>; 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Superintendência de Vigilância em Saúde do Estado do Amapá - SVS/AP, Macapá, Amapá, Brazil.; Federal University of aMAPA, Universidade Federal do Amapá - UNIFAP), Macapá, Amapá, Brazil.<br /><searchLink fieldCode="AU" term="%22Gonzalez-Ceron+L%22">Gonzalez-Ceron L</searchLink>; Regional Centre for Public Health Research, National Institute for Public Health, Tapachula, Chiapas, Mexico.<br /><searchLink fieldCode="AU" term="%22Grigg+MJ%22">Grigg MJ</searchLink>; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia.; Infectious Diseases Society Sabah-Menzies School of Health Research Clinical Research Unit, Kota Kinabalu, Sabah, Malaysia.<br /><searchLink fieldCode="AU" term="%22Karunajeewa+H%22">Karunajeewa H</searchLink>; Department of Medicine-Western Health, Melbourne Medical School, The University of Melbourne, St. Albans, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Lacerda+MVG%22">Lacerda MVG</searchLink>; Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Brazil.; Instituto Leônidas E Maria Deane, Fiocruz, Manaus, Brazil.; University of Texas Medical Branch, Galveston, USA.<br /><searchLink fieldCode="AU" term="%22Ladeia-Andrade+S%22">Ladeia-Andrade S</searchLink>; Laboratory of Parasitic Diseases, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Brazil.; Institute of Hygiene and Tropical Medicine, Global Health and Tropical Medicine, NOVA University of Lisbon, Lisbon, Portugal.<br /><searchLink fieldCode="AU" term="%22Leslie+T%22">Leslie T</searchLink>; Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK.; HealthNet-TPO, Kabul, Afghanistan.<br /><searchLink fieldCode="AU" term="%22Ley+B%22">Ley B</searchLink>; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia.<br /><searchLink fieldCode="AU" term="%22Lidia+K%22">Lidia K</searchLink>; The Department of Pharmacology and Therapy, Faculty of Medicine and Veterinary Medicine, Universitas Nusa Cendana, Kupang, Indonesia.<br /><searchLink fieldCode="AU" term="%22Llanos-Cuentas+A%22">Llanos-Cuentas A</searchLink>; Unit of Leishmaniasis and Malaria, Instituto de Medicina Tropical 'Alexander Von Humboldt', Universidad Peruana Cayetano Heredia, Lima, Peru.<br /><searchLink fieldCode="AU" term="%22Longley+RJ%22">Longley RJ</searchLink>; Mahidol Vivax Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Infection and Global Health Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Manning+L%22">Manning L</searchLink>; Medical School, University of Western Australia, Crawley, Australia.; Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, Perth, Australia.; Department of Infectious Diseases, Fiona Stanley Hospital, Perth, Australia.<br /><searchLink fieldCode="AU" term="%22Mekonnen+DA%22">Mekonnen DA</searchLink>; Malaria and Neglected Tropical Diseases Directorate, Armauer Hansen Research Institute, Addis Ababa, Ethiopia.; 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Department of Pediatrics, Medical Faculty, Universitas Sumatera Utara, Medan, North Sumatera, Indonesia.<br /><searchLink fieldCode="AU" term="%22Pereira+DB%22">Pereira DB</searchLink>; Centro de Pesquisa Em Medicina Tropical de Rondonia (CEPEM), Porto Velho, Brazil.; Fundação Universidade Federal de Rondonia (UNIR), Porto Velho, Brazil.<br /><searchLink fieldCode="AU" term="%22Poespoprodjo+JR%22">Poespoprodjo JR</searchLink>; Mimika District Hospital, Timika, Indonesia.; Timika Malaria Research Programme, Papuan Health and Community Development Foundation, Timika, Indonesia.; Paediatric Research Office, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.<br /><searchLink fieldCode="AU" term="%22Pukrittayakamee+S%22">Pukrittayakamee S</searchLink>; Mahidol Oxford Tropical Medicine Research Unit (MORU), Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.<br /><searchLink fieldCode="AU" term="%22Rijal+KR%22">Rijal KR</searchLink>; 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Parasitology and Entomology, National Institute of Malariology, Hanoi, Vietnam.<br /><searchLink fieldCode="AU" term="%22Thriemer+K%22">Thriemer K</searchLink>; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia.<br /><searchLink fieldCode="AU" term="%22Vieira+JLF%22">Vieira JLF</searchLink>; Federal University of Pará (Universidade Federal Do Pará - UFPA), Belém, Pará, Brazil.<br /><searchLink fieldCode="AU" term="%22White+NJ%22">White NJ</searchLink>; Mahidol Oxford Tropical Medicine Research Unit (MORU), Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Yeshiwondim+AK%22">Yeshiwondim AK</searchLink>; World Health Organization Country Office for Addis Ababa, Addis Ababa, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Zuluaga-Idarraga+LM%22">Zuluaga-Idarraga LM</searchLink>; Grupo Malaria, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.; Facultad Nacional de Salud Publica, Universidad de Antioquia, Medellín, Colombia.<br /><searchLink fieldCode="AU" term="%22Guerin+PJ%22">Guerin PJ</searchLink>; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.; WorldWide Antimalarial Resistance Network (WWARN), Oxford, UK.; Infectious Diseases Data Observatory (IDDO), Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Simpson+JA%22">Simpson JA</searchLink>; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.; WorldWide Antimalarial Resistance Network (WWARN), Asia-Pacific Regional Centre, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Price+RN%22">Price RN</searchLink>; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia.; 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            NameFull: Pereira DB
      – PersonEntity:
          Name:
            NameFull: Poespoprodjo JR
      – PersonEntity:
          Name:
            NameFull: Pukrittayakamee S
      – PersonEntity:
          Name:
            NameFull: Rijal KR
      – PersonEntity:
          Name:
            NameFull: Saravu K
      – PersonEntity:
          Name:
            NameFull: Siqueira AM
      – PersonEntity:
          Name:
            NameFull: Sutanto I
      – PersonEntity:
          Name:
            NameFull: Taylor WRJ
      – PersonEntity:
          Name:
            NameFull: Thanh PV
      – PersonEntity:
          Name:
            NameFull: Thriemer K
      – PersonEntity:
          Name:
            NameFull: Vieira JLF
      – PersonEntity:
          Name:
            NameFull: White NJ
      – PersonEntity:
          Name:
            NameFull: Yeshiwondim AK
      – PersonEntity:
          Name:
            NameFull: Zuluaga-Idarraga LM
      – PersonEntity:
          Name:
            NameFull: Guerin PJ
      – PersonEntity:
          Name:
            NameFull: Simpson JA
      – PersonEntity:
          Name:
            NameFull: Price RN
      – PersonEntity:
          Name:
            NameFull: Commons RJ
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 14
              M: 11
              Text: 2025 Nov 14
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 1475-2875
          Numbering:
            – Type: volume
              Value: 24
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Malaria journal
              Type: main
ResultId 1