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The German Cancer Consortium (DKTK) multi-center prospective phase 1/2 68Ga-PSMA-11 PET-imaging trial in newly-diagnosed high-risk prostate cancer: Safety and diagnostic accuracy compared to histopathology and their impact on patient management.

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Title: The German Cancer Consortium (DKTK) multi-center prospective phase 1/2 68Ga-PSMA-11 PET-imaging trial in newly-diagnosed high-risk prostate cancer: Safety and diagnostic accuracy compared to histopathology and their impact on patient management.
Authors: Giesel FL; Department of Nuclear Medicine, Heidelberg University Hospital, Heidelberg, Germany.; Department of Nuclear Medicine, Medical Faculty and University Hospital Duesseldorf, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany.; Institute for Radiation Sciences, Osaka University, Osaka, Japan., Koerber SA; Department of Radiation Oncology, Barmherzige Brüder Hospital Regensburg, Regensburg, Germany.; Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany., Hadaschik B; Department of Urology, University Hospital Essen, Essen, Germany., Kiefer S; Institute for Surgical Pathology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany., Schwarzenboeck S; Department of Nuclear Medicine, University Medical Centre, Rostock, Germany., Rahbar K; Department of Nuclear Medicine, Münster University Hospital, Münster, Germany., Derlin T; Department of Nuclear Medicine, Hannover Medical School, Hanover, Germany., Grott CA; Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany., Heck M; Department of Urology, TUM University Hospital, School of Medicine and Health, Technical University Munich, Munich, Germany., Jilg C; Department of Urology, Faculty of Medicine, University of Freiburg-Medical Centre, Freiburg, Germany., Meyer PT; Department of Nuclear Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Ruf J; Department of Nuclear Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Schmidt K; ABX-CRO, Dresden, Germany., Kotzerke J; Department of Nuclear Medicine, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., la Fougère C; Department of Nuclear Medicine and Clinical Molecular Imaging, University Hospital Tuebingen, Tuebingen, Germany., Reischl G; Department of Preclinical Imaging and Radiopharmacy, University Hospital Tuebingen, Tuebingen, Germany., Virgolini I; Department of Nuclear Medicine, University Hospital Innsbruck, Innsbruck, Austria., Herrmann K; Department of Nuclear Medicine, West German Cancer Center, University Hospital Essen, Essen, Germany.; Cancer Consortium partner site Essen/Düsseldorf, DKFZ and University Hospital Essen, Essen, Germany., Burger IA; Department of Nuclear Medicine, Kantonsspital Baden, Affiliated Hospital for Research and Teaching of the Faculty of Medicine of the University of Zurich, Baden, Switzerland.; Department of Nuclear Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland., Lorenzini T; Department of Nuclear Medicine, TUM University Hospital, School of Medicine and Health, Technical University Munich, Munich, Germany.; German Cancer Consortium (DKTK), Munich, Germany., Werner M; Institute for Surgical Pathology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany., Stenzinger A; Institute of Pathology, Division of Molecular Pathology, University Hospital Heidelberg, Heidelberg, Germany., Schwamborn K; Institute of Pathology, Technical University of Munich, School of Medicine, Munich, Germany., Radtke JP; Department of Urology, Medical Faculty, University Duesseldorf, Düsseldorf, Germany.; Department of Urology, University Hospital Essen, Essen, Germany., Hohenfellner M; Department of Urology, University Hospital Heidelberg and National Center for Tumor Diseases (NCT) Heidelberg, Heidelberg, Germany., Debus J; Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany., Weber WA; Department of Nuclear Medicine, TUM University Hospital, School of Medicine and Health, Technical University Munich, Munich, Germany.; German Cancer Consortium (DKTK), Munich, Germany.; Center for Translational Cancer Research (TranslaTUM), Technical University of Munich, Munich, Germany.; Bavarian Cancer Research Center (BZKF), Munich, Germany., Haberkorn U; Department of Nuclear Medicine, Heidelberg University Hospital, Heidelberg, Germany., Kopka K; Division of Radiopharmaceutical Chemistry, German Cancer Research Center, Heidelberg, Germany.; Helmholtz-Zentrum Dresden-Rossendorf e.V., Institute of Radiopharmaceutical Cancer Research, Dresden, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany., Eiber M; Department of Nuclear Medicine, TUM University Hospital, School of Medicine and Health, Technical University Munich, Munich, Germany. matthias.eiber@tum.de.; German Cancer Consortium (DKTK), Munich, Germany. matthias.eiber@tum.de.; Bavarian Cancer Research Center (BZKF), Munich, Germany. matthias.eiber@tum.de.
Corporate Authors: 68Ga-PSMA-11 DKTK trial contributors
Source: European journal of nuclear medicine and molecular imaging [Eur J Nucl Med Mol Imaging] 2026 Apr; Vol. 53 (5), pp. 2994-3006. Date of Electronic Publication: 2025 Nov 15.
Publication Type: Journal Article; Multicenter Study; Clinical Trial, Phase II; Clinical Trial, Phase I; Comparative Study
Journal Info: Publisher: Springer-Verlag Berlin Country of Publication: Germany NLM ID: 101140988 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1619-7089 (Electronic) Linking ISSN: 16197070 NLM ISO Abbreviation: Eur J Nucl Med Mol Imaging Subsets: MEDLINE
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  Data: The German Cancer Consortium (DKTK) multi-center prospective phase 1/2 <superscript>68</superscript>Ga-PSMA-11 PET-imaging trial in newly-diagnosed high-risk prostate cancer: Safety and diagnostic accuracy compared to histopathology and their impact on patient management.
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  Data: <searchLink fieldCode="AU" term="%22Giesel+FL%22">Giesel FL</searchLink>; Department of Nuclear Medicine, Heidelberg University Hospital, Heidelberg, Germany.; Department of Nuclear Medicine, Medical Faculty and University Hospital Duesseldorf, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany.; Institute for Radiation Sciences, Osaka University, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Koerber+SA%22">Koerber SA</searchLink>; Department of Radiation Oncology, Barmherzige Brüder Hospital Regensburg, Regensburg, Germany.; Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Hadaschik+B%22">Hadaschik B</searchLink>; Department of Urology, University Hospital Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Kiefer+S%22">Kiefer S</searchLink>; Institute for Surgical Pathology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany.<br /><searchLink fieldCode="AU" term="%22Schwarzenboeck+S%22">Schwarzenboeck S</searchLink>; Department of Nuclear Medicine, University Medical Centre, Rostock, Germany.<br /><searchLink fieldCode="AU" term="%22Rahbar+K%22">Rahbar K</searchLink>; Department of Nuclear Medicine, Münster University Hospital, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Derlin+T%22">Derlin T</searchLink>; Department of Nuclear Medicine, Hannover Medical School, Hanover, Germany.<br /><searchLink fieldCode="AU" term="%22Grott+CA%22">Grott CA</searchLink>; Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Heck+M%22">Heck M</searchLink>; Department of Urology, TUM University Hospital, School of Medicine and Health, Technical University Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Jilg+C%22">Jilg C</searchLink>; Department of Urology, Faculty of Medicine, University of Freiburg-Medical Centre, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Meyer+PT%22">Meyer PT</searchLink>; Department of Nuclear Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Ruf+J%22">Ruf J</searchLink>; Department of Nuclear Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Schmidt+K%22">Schmidt K</searchLink>; ABX-CRO, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Kotzerke+J%22">Kotzerke J</searchLink>; Department of Nuclear Medicine, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22la+Fougère+C%22">la Fougère C</searchLink>; Department of Nuclear Medicine and Clinical Molecular Imaging, University Hospital Tuebingen, Tuebingen, Germany.<br /><searchLink fieldCode="AU" term="%22Reischl+G%22">Reischl G</searchLink>; Department of Preclinical Imaging and Radiopharmacy, University Hospital Tuebingen, Tuebingen, Germany.<br /><searchLink fieldCode="AU" term="%22Virgolini+I%22">Virgolini I</searchLink>; Department of Nuclear Medicine, University Hospital Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Herrmann+K%22">Herrmann K</searchLink>; Department of Nuclear Medicine, West German Cancer Center, University Hospital Essen, Essen, Germany.; Cancer Consortium partner site Essen/Düsseldorf, DKFZ and University Hospital Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Burger+IA%22">Burger IA</searchLink>; Department of Nuclear Medicine, Kantonsspital Baden, Affiliated Hospital for Research and Teaching of the Faculty of Medicine of the University of Zurich, Baden, Switzerland.; Department of Nuclear Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Lorenzini+T%22">Lorenzini T</searchLink>; Department of Nuclear Medicine, TUM University Hospital, School of Medicine and Health, Technical University Munich, Munich, Germany.; German Cancer Consortium (DKTK), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Werner+M%22">Werner M</searchLink>; Institute for Surgical Pathology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany.<br /><searchLink fieldCode="AU" term="%22Stenzinger+A%22">Stenzinger A</searchLink>; Institute of Pathology, Division of Molecular Pathology, University Hospital Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Schwamborn+K%22">Schwamborn K</searchLink>; Institute of Pathology, Technical University of Munich, School of Medicine, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Radtke+JP%22">Radtke JP</searchLink>; Department of Urology, Medical Faculty, University Duesseldorf, Düsseldorf, Germany.; Department of Urology, University Hospital Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Hohenfellner+M%22">Hohenfellner M</searchLink>; Department of Urology, University Hospital Heidelberg and National Center for Tumor Diseases (NCT) Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Debus+J%22">Debus J</searchLink>; Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Weber+WA%22">Weber WA</searchLink>; Department of Nuclear Medicine, TUM University Hospital, School of Medicine and Health, Technical University Munich, Munich, Germany.; German Cancer Consortium (DKTK), Munich, Germany.; Center for Translational Cancer Research (TranslaTUM), Technical University of Munich, Munich, Germany.; Bavarian Cancer Research Center (BZKF), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Haberkorn+U%22">Haberkorn U</searchLink>; Department of Nuclear Medicine, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Kopka+K%22">Kopka K</searchLink>; Division of Radiopharmaceutical Chemistry, German Cancer Research Center, Heidelberg, Germany.; Helmholtz-Zentrum Dresden-Rossendorf e.V., Institute of Radiopharmaceutical Cancer Research, Dresden, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Eiber+M%22">Eiber M</searchLink>; Department of Nuclear Medicine, TUM University Hospital, School of Medicine and Health, Technical University Munich, Munich, Germany. matthias.eiber@tum.de.; German Cancer Consortium (DKTK), Munich, Germany. matthias.eiber@tum.de.; Bavarian Cancer Research Center (BZKF), Munich, Germany. matthias.eiber@tum.de.
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