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The tau biomarker cascade is condensed in Down syndrome compared with sporadic Alzheimer's disease.

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Title: The tau biomarker cascade is condensed in Down syndrome compared with sporadic Alzheimer's disease.
Authors: Zammit MD; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA., Bruzzone H; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA., Cody KA; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA., Morse J; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA., Wilson R; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA., Bettcher BT; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA.; Department of Medical Physics, University of Wisconsin-Madison, Madison, WI 53705, USA., McLachlan MJ; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA.; Department of Medical Physics, University of Wisconsin-Madison, Madison, WI 53705, USA., McVea AK; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA.; Department of Medical Physics, University of Wisconsin-Madison, Madison, WI 53705, USA., DiFilippo AH; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA.; Department of Medical Physics, University of Wisconsin-Madison, Madison, WI 53705, USA., Carey FJ; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.; Department of Medicine, University of Wisconsin-Madison, Madison, WI 53792, USA., Janelidze S; Clinical Memory Research Unit, Lund University, Lund 221 00, Sweden., Hansson O; Clinical Memory Research Unit, Lund University, Lund 221 00, Sweden., Price JC; Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA., Laymon CM; Department of Radiology, University of Pittsburgh, Pittsburgh, PA 15260, USA.; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15260, USA., Minhas DS; Department of Radiology, University of Pittsburgh, Pittsburgh, PA 15260, USA., Luo W; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15260, USA., Rosas HD; Department of Neurology, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA., Lai F; Department of Neurology, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA., Lee JH; G. H. Sergievsky Center, Department of Neurology, Columbia University Irving Medical Center, New York, NY 10032, USA., Lao PJ; G. H. Sergievsky Center, Department of Neurology, Columbia University Irving Medical Center, New York, NY 10032, USA., Ances BM; Department of Neurology, Washington University in St. Louis, St. Louis, MO 63130, USA., Krinsky-McHale SJ; Department of Psychology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA., Hom CL; Department of Psychiatry and Human Behavior, University of California Irvine School of Medicine, Orange, CA 92617, USA., Hartley SL; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA., Zaman SH; Cambridge Intellectual and Developmental Disabilities Research Group, University of Cambridge, Cambridge CB2 1TN, UK., Johnson SC; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.; Department of Medicine, University of Wisconsin-Madison, Madison, WI 53792, USA., Cohen AD; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15260, USA., Head E; Department of Pathology and Laboratory Medicine, University of California Irvine, Irvine, CA 92617, USA., Mapstone ME; Department of Neurology, Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92617, USA., Handen BL; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15260, USA., Christian BT; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA.; Department of Medical Physics, University of Wisconsin-Madison, Madison, WI 53705, USA., Tudorascu DL; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15260, USA., Langhough RE; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA., Betthauser TJ; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.; Department of Medical Physics, University of Wisconsin-Madison, Madison, WI 53705, USA.; Department of Medicine, University of Wisconsin-Madison, Madison, WI 53792, USA.
Corporate Authors: Alzheimer Biomarker Consortium–Down Syndrome
Source: Brain : a journal of neurology [Brain] 2026 Jul 07; Vol. 149 (7), pp. 2449-2462.
Publication Type: Journal Article; Comparative Study
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0372537 Publication Model: Print Cited Medium: Internet ISSN: 1460-2156 (Electronic) Linking ISSN: 00068950 NLM ISO Abbreviation: Brain Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The tau biomarker cascade is condensed in Down syndrome compared with sporadic Alzheimer's disease.
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  Data: <searchLink fieldCode="AU" term="%22Zammit+MD%22">Zammit MD</searchLink>; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA.<br /><searchLink fieldCode="AU" term="%22Bruzzone+H%22">Bruzzone H</searchLink>; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.<br /><searchLink fieldCode="AU" term="%22Cody+KA%22">Cody KA</searchLink>; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.<br /><searchLink fieldCode="AU" term="%22Morse+J%22">Morse J</searchLink>; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.<br /><searchLink fieldCode="AU" term="%22Wilson+R%22">Wilson R</searchLink>; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.<br /><searchLink fieldCode="AU" term="%22Bettcher+BT%22">Bettcher BT</searchLink>; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA.; Department of Medical Physics, University of Wisconsin-Madison, Madison, WI 53705, USA.<br /><searchLink fieldCode="AU" term="%22McLachlan+MJ%22">McLachlan MJ</searchLink>; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA.; Department of Medical Physics, University of Wisconsin-Madison, Madison, WI 53705, USA.<br /><searchLink fieldCode="AU" term="%22McVea+AK%22">McVea AK</searchLink>; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA.; Department of Medical Physics, University of Wisconsin-Madison, Madison, WI 53705, USA.<br /><searchLink fieldCode="AU" term="%22DiFilippo+AH%22">DiFilippo AH</searchLink>; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA.; Department of Medical Physics, University of Wisconsin-Madison, Madison, WI 53705, USA.<br /><searchLink fieldCode="AU" term="%22Carey+FJ%22">Carey FJ</searchLink>; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.; Department of Medicine, University of Wisconsin-Madison, Madison, WI 53792, USA.<br /><searchLink fieldCode="AU" term="%22Janelidze+S%22">Janelidze S</searchLink>; Clinical Memory Research Unit, Lund University, Lund 221 00, Sweden.<br /><searchLink fieldCode="AU" term="%22Hansson+O%22">Hansson O</searchLink>; Clinical Memory Research Unit, Lund University, Lund 221 00, Sweden.<br /><searchLink fieldCode="AU" term="%22Price+JC%22">Price JC</searchLink>; Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA.<br /><searchLink fieldCode="AU" term="%22Laymon+CM%22">Laymon CM</searchLink>; Department of Radiology, University of Pittsburgh, Pittsburgh, PA 15260, USA.; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15260, USA.<br /><searchLink fieldCode="AU" term="%22Minhas+DS%22">Minhas DS</searchLink>; Department of Radiology, University of Pittsburgh, Pittsburgh, PA 15260, USA.<br /><searchLink fieldCode="AU" term="%22Luo+W%22">Luo W</searchLink>; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15260, USA.<br /><searchLink fieldCode="AU" term="%22Rosas+HD%22">Rosas HD</searchLink>; Department of Neurology, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA.<br /><searchLink fieldCode="AU" term="%22Lai+F%22">Lai F</searchLink>; Department of Neurology, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA.<br /><searchLink fieldCode="AU" term="%22Lee+JH%22">Lee JH</searchLink>; G. H. Sergievsky Center, Department of Neurology, Columbia University Irving Medical Center, New York, NY 10032, USA.<br /><searchLink fieldCode="AU" term="%22Lao+PJ%22">Lao PJ</searchLink>; G. H. Sergievsky Center, Department of Neurology, Columbia University Irving Medical Center, New York, NY 10032, USA.<br /><searchLink fieldCode="AU" term="%22Ances+BM%22">Ances BM</searchLink>; Department of Neurology, Washington University in St. Louis, St. Louis, MO 63130, USA.<br /><searchLink fieldCode="AU" term="%22Krinsky-McHale+SJ%22">Krinsky-McHale SJ</searchLink>; Department of Psychology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA.<br /><searchLink fieldCode="AU" term="%22Hom+CL%22">Hom CL</searchLink>; Department of Psychiatry and Human Behavior, University of California Irvine School of Medicine, Orange, CA 92617, USA.<br /><searchLink fieldCode="AU" term="%22Hartley+SL%22">Hartley SL</searchLink>; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA.<br /><searchLink fieldCode="AU" term="%22Zaman+SH%22">Zaman SH</searchLink>; Cambridge Intellectual and Developmental Disabilities Research Group, University of Cambridge, Cambridge CB2 1TN, UK.<br /><searchLink fieldCode="AU" term="%22Johnson+SC%22">Johnson SC</searchLink>; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.; Department of Medicine, University of Wisconsin-Madison, Madison, WI 53792, USA.<br /><searchLink fieldCode="AU" term="%22Cohen+AD%22">Cohen AD</searchLink>; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15260, USA.<br /><searchLink fieldCode="AU" term="%22Head+E%22">Head E</searchLink>; Department of Pathology and Laboratory Medicine, University of California Irvine, Irvine, CA 92617, USA.<br /><searchLink fieldCode="AU" term="%22Mapstone+ME%22">Mapstone ME</searchLink>; Department of Neurology, Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92617, USA.<br /><searchLink fieldCode="AU" term="%22Handen+BL%22">Handen BL</searchLink>; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15260, USA.<br /><searchLink fieldCode="AU" term="%22Christian+BT%22">Christian BT</searchLink>; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA.; Department of Medical Physics, University of Wisconsin-Madison, Madison, WI 53705, USA.<br /><searchLink fieldCode="AU" term="%22Tudorascu+DL%22">Tudorascu DL</searchLink>; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15260, USA.<br /><searchLink fieldCode="AU" term="%22Langhough+RE%22">Langhough RE</searchLink>; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.<br /><searchLink fieldCode="AU" term="%22Betthauser+TJ%22">Betthauser TJ</searchLink>; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.; Department of Medical Physics, University of Wisconsin-Madison, Madison, WI 53705, USA.; Department of Medicine, University of Wisconsin-Madison, Madison, WI 53792, USA.
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  Data: <searchLink fieldCode="JN" term="%220372537%22">Brain : a journal of neurology</searchLink> [Brain] 2026 Jul 07; Vol. 149 (7), pp. 2449-2462.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Oxford+University+Press%22">Oxford University Press </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>0372537 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1460-2156 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200068950%22">00068950 </searchLink><i>NLM ISO Abbreviation: </i>Brain <i>Subsets: </i>MEDLINE
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