First-line treatment efficacy of anti-EGFR versus anti-VEGF antibodies in BRAFV600E-mutated metastatic colorectal cancer according to primary tumor sidedness: A pooled analysis of seven clinical trials performed in the first-line treatment of mCRC (German AIO Study Group).

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Title: First-line treatment efficacy of anti-EGFR versus anti-VEGF antibodies in BRAFV600E-mutated metastatic colorectal cancer according to primary tumor sidedness: A pooled analysis of seven clinical trials performed in the first-line treatment of mCRC (German AIO Study Group).
Authors: Weiss L; Department of Medicine III and Comprehensive Cancer Center (CCC Munich LMU), University Hospital, LMU Munich, Munich, Germany. Electronic address: Lena.Weiss@med.uni-muenchen.de., Stintzing S; Department of Hematology, Oncology and Cancer Immunology (CCM), Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany; DKTK Heidelberg, Partner Site Berlin, Germany., Modest DP; Department of Hematology, Oncology and Cancer Immunology (CCM), Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany., Stahler A; Department of Hematology, Oncology and Cancer Immunology (CCM), Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany., von Weikersthal LF; MVZ Gesundheitszentrum St. Marien GmbH, Amberg, Germany., Reinacher-Schick A; Department of Hematology, Oncology and Palliative Care, St. Josef-Hospital, Ruhr-University Bochum, Bochum, Germany., Decker T; Onkologie Ravensburg, Ravensburg, Germany., Probst V; Department of Medicine III and Comprehensive Cancer Center (CCC Munich LMU), University Hospital, LMU Munich, Munich, Germany., Heinrich K; Department of Medicine III and Comprehensive Cancer Center (CCC Munich LMU), University Hospital, LMU Munich, Munich, Germany., Schwaner I; Onkologische Schwerpunktpraxis Kurfürstendamm, Berlin, Germany., Kaiser F; VK&K Oncology GmbH, Landshut, Germany., Pihusch R; MVZ Praxis Pihusch, Rosenheim, Germany., Fuchs M; München Klinik Bogenhausen, Department of Gastroenterology, Hepatology and Gastrointestinal Oncology, Munich, Germany., Held S; ClinAssess GmbH, Leverkusen, Germany., Alig A; Department of Hematology, Oncology and Cancer Immunology (CCM), Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany., Gruenberger B; Universitätsklinikum Wiener Neustadt, Wiener Neustadt, Austria., Prager GW; Medical University of Vienna, Department of Medicine I, Vienna, Austria., Tougeron D; Department of Hepato-Gastroenterology, Poitiers University Hospital and University of Poitiers, Poitiers, France., Taieb J; CARPEM comprehensive cancer center, University Paris-Cité, department of Gastroenterology and GI Oncology, Hôpital Européen Georges Pompidou, Paris, France., Heinemann V; Department of Medicine III and Comprehensive Cancer Center (CCC Munich LMU), University Hospital, LMU Munich, Munich, Germany.
Source: European journal of cancer (Oxford, England : 1990) [Eur J Cancer] 2026 Jan; Vol. 232, pp. 116105. Date of Electronic Publication: 2025 Nov 13.
Publication Type: Comparative Study; Journal Article; Meta-Analysis; Comparative Study
Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9005373 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0852 (Electronic) Linking ISSN: 09598049 NLM ISO Abbreviation: Eur J Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: First-line treatment efficacy of anti-EGFR versus anti-VEGF antibodies in BRAF<superscript>V600E</superscript>-mutated metastatic colorectal cancer according to primary tumor sidedness: A pooled analysis of seven clinical trials performed in the first-line treatment of mCRC (German AIO Study Group).
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  Data: <searchLink fieldCode="AU" term="%22Weiss+L%22">Weiss L</searchLink>; Department of Medicine III and Comprehensive Cancer Center (CCC Munich LMU), University Hospital, LMU Munich, Munich, Germany. Electronic address: Lena.Weiss@med.uni-muenchen.de.<br /><searchLink fieldCode="AU" term="%22Stintzing+S%22">Stintzing S</searchLink>; Department of Hematology, Oncology and Cancer Immunology (CCM), Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany; DKTK Heidelberg, Partner Site Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Modest+DP%22">Modest DP</searchLink>; Department of Hematology, Oncology and Cancer Immunology (CCM), Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Stahler+A%22">Stahler A</searchLink>; Department of Hematology, Oncology and Cancer Immunology (CCM), Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22von+Weikersthal+LF%22">von Weikersthal LF</searchLink>; MVZ Gesundheitszentrum St. Marien GmbH, Amberg, Germany.<br /><searchLink fieldCode="AU" term="%22Reinacher-Schick+A%22">Reinacher-Schick A</searchLink>; Department of Hematology, Oncology and Palliative Care, St. Josef-Hospital, Ruhr-University Bochum, Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Decker+T%22">Decker T</searchLink>; Onkologie Ravensburg, Ravensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Probst+V%22">Probst V</searchLink>; Department of Medicine III and Comprehensive Cancer Center (CCC Munich LMU), University Hospital, LMU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Heinrich+K%22">Heinrich K</searchLink>; Department of Medicine III and Comprehensive Cancer Center (CCC Munich LMU), University Hospital, LMU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Schwaner+I%22">Schwaner I</searchLink>; Onkologische Schwerpunktpraxis Kurfürstendamm, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Kaiser+F%22">Kaiser F</searchLink>; VK&K Oncology GmbH, Landshut, Germany.<br /><searchLink fieldCode="AU" term="%22Pihusch+R%22">Pihusch R</searchLink>; MVZ Praxis Pihusch, Rosenheim, Germany.<br /><searchLink fieldCode="AU" term="%22Fuchs+M%22">Fuchs M</searchLink>; München Klinik Bogenhausen, Department of Gastroenterology, Hepatology and Gastrointestinal Oncology, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Held+S%22">Held S</searchLink>; ClinAssess GmbH, Leverkusen, Germany.<br /><searchLink fieldCode="AU" term="%22Alig+A%22">Alig A</searchLink>; Department of Hematology, Oncology and Cancer Immunology (CCM), Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Gruenberger+B%22">Gruenberger B</searchLink>; Universitätsklinikum Wiener Neustadt, Wiener Neustadt, Austria.<br /><searchLink fieldCode="AU" term="%22Prager+GW%22">Prager GW</searchLink>; Medical University of Vienna, Department of Medicine I, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Tougeron+D%22">Tougeron D</searchLink>; Department of Hepato-Gastroenterology, Poitiers University Hospital and University of Poitiers, Poitiers, France.<br /><searchLink fieldCode="AU" term="%22Taieb+J%22">Taieb J</searchLink>; CARPEM comprehensive cancer center, University Paris-Cité, department of Gastroenterology and GI Oncology, Hôpital Européen Georges Pompidou, Paris, France.<br /><searchLink fieldCode="AU" term="%22Heinemann+V%22">Heinemann V</searchLink>; Department of Medicine III and Comprehensive Cancer Center (CCC Munich LMU), University Hospital, LMU Munich, Munich, Germany.
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  Data: <searchLink fieldCode="JN" term="%229005373%22">European journal of cancer (Oxford, England : 1990)</searchLink> [Eur J Cancer] 2026 Jan; Vol. 232, pp. 116105. <i>Date of Electronic Publication: </i>2025 Nov 13.
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