Unlocking dexmedetomidine's therapeutic potential in multiple sclerosis: Dual modulation of PI3K/Akt/BDNF and TLR4/NF-κB pathways in EAE rats.
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| Title: | Unlocking dexmedetomidine's therapeutic potential in multiple sclerosis: Dual modulation of PI3K/Akt/BDNF and TLR4/NF-κB pathways in EAE rats. |
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| Authors: | Salem MA; Department of Pharmacology, Toxicology and Biochemistry, Faculty of Pharmacy, Future University in Egypt, 90th St., 11835, Cairo, Egypt. Electronic address: mohamed.saleem@fue.edu.eg., Rabie MA; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Κasr El-Aini St., 11562, Cairo, Egypt. Electronic address: mostafa.mohammed@pharma.cu.edu.eg., El Maraghy NN; Department of Pharmacology, Toxicology and Biochemistry, Faculty of Pharmacy, Future University in Egypt, 90th St., 11835, Cairo, Egypt. Electronic address: nabila.elmaraghy@fue.edu.eg., El-Said YAM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Κasr El-Aini St., 11562, Cairo, Egypt. Electronic address: yasmin.ahmed@pharma.cu.edu.eg., El Sayed NS; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Κasr El-Aini St., 11562, Cairo, Egypt. Electronic address: nesrine.salah@pharma.cu.edu.eg., Mansour SM; Department of Pharmacology, Toxicology and Biochemistry, Faculty of Pharmacy, Future University in Egypt, 90th St., 11835, Cairo, Egypt; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Κasr El-Aini St., 11562, Cairo, Egypt. Electronic address: suzan.mohamed@fue.edu.eg. |
| Source: | European journal of pharmacology [Eur J Pharmacol] 2025 Dec 05; Vol. 1008, pp. 178365. Date of Electronic Publication: 2025 Nov 13. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41241331 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Unlocking dexmedetomidine's therapeutic potential in multiple sclerosis: Dual modulation of PI3K/Akt/BDNF and TLR4/NF-κB pathways in EAE rats. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Salem+MA%22">Salem MA</searchLink>; Department of Pharmacology, Toxicology and Biochemistry, Faculty of Pharmacy, Future University in Egypt, 90th St., 11835, Cairo, Egypt. Electronic address: mohamed.saleem@fue.edu.eg.<br /><searchLink fieldCode="AU" term="%22Rabie+MA%22">Rabie MA</searchLink>; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Κasr El-Aini St., 11562, Cairo, Egypt. Electronic address: mostafa.mohammed@pharma.cu.edu.eg.<br /><searchLink fieldCode="AU" term="%22El+Maraghy+NN%22">El Maraghy NN</searchLink>; Department of Pharmacology, Toxicology and Biochemistry, Faculty of Pharmacy, Future University in Egypt, 90th St., 11835, Cairo, Egypt. Electronic address: nabila.elmaraghy@fue.edu.eg.<br /><searchLink fieldCode="AU" term="%22El-Said+YAM%22">El-Said YAM</searchLink>; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Κasr El-Aini St., 11562, Cairo, Egypt. Electronic address: yasmin.ahmed@pharma.cu.edu.eg.<br /><searchLink fieldCode="AU" term="%22El+Sayed+NS%22">El Sayed NS</searchLink>; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Κasr El-Aini St., 11562, Cairo, Egypt. Electronic address: nesrine.salah@pharma.cu.edu.eg.<br /><searchLink fieldCode="AU" term="%22Mansour+SM%22">Mansour SM</searchLink>; Department of Pharmacology, Toxicology and Biochemistry, Faculty of Pharmacy, Future University in Egypt, 90th St., 11835, Cairo, Egypt; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Κasr El-Aini St., 11562, Cairo, Egypt. Electronic address: suzan.mohamed@fue.edu.eg. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%221254354%22">European journal of pharmacology</searchLink> [Eur J Pharmacol] 2025 Dec 05; Vol. 1008, pp. 178365. <i>Date of Electronic Publication: </i>2025 Nov 13. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science%22">Elsevier Science </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>1254354 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1879-0712 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200142999%22">00142999 </searchLink><i>NLM ISO Abbreviation: </i>Eur J Pharmacol <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41241331 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.ejphar.2025.178365 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 178365 Titles: – TitleFull: Unlocking dexmedetomidine's therapeutic potential in multiple sclerosis: Dual modulation of PI3K/Akt/BDNF and TLR4/NF-κB pathways in EAE rats. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Salem MA – PersonEntity: Name: NameFull: Rabie MA – PersonEntity: Name: NameFull: El Maraghy NN – PersonEntity: Name: NameFull: El-Said YAM – PersonEntity: Name: NameFull: El Sayed NS – PersonEntity: Name: NameFull: Mansour SM IsPartOfRelationships: – BibEntity: Dates: – D: 05 M: 12 Text: 2025 Dec 05 Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 1879-0712 Numbering: – Type: volume Value: 1008 Titles: – TitleFull: European journal of pharmacology Type: main |
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