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Safety and pharmacokinetics of SOR102, an oral bispecific inhibitor of TNF and interleukin-23 in healthy participants and patients with ulcerative colitis: a first-in-human, double-blind, randomised, placebo-controlled, phase 1 trial.

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Title: Safety and pharmacokinetics of SOR102, an oral bispecific inhibitor of TNF and interleukin-23 in healthy participants and patients with ulcerative colitis: a first-in-human, double-blind, randomised, placebo-controlled, phase 1 trial.
Authors: Jairath V; Division of Gastroenterology, Department of Medicine, Western University, London, ON, Canada; Department of Epidemiology and Biostatistics, Western University, London, ON, Canada. Electronic address: vjairath@uwo.ca., Danese S; Department of Gastroenterology and Endoscopy, IRCCS Ospedale San Raffaele and University Vita-Salute San Raffaele, Milan, Italy., D'Haens GR; Department of Gastroenterology and Hepatology, Amsterdam University Medical Centre, Academic Medical Centre, Amsterdam, Netherlands., Feagan BG; Division of Gastroenterology, Department of Medicine, Western University, London, ON, Canada; Department of Epidemiology and Biostatistics, Western University, London, ON, Canada., Peyrin-Biroulet L; Department of Gastroenterology, CHRU Nancy, INSERM NGERE, Université de Lorraine, Vandœuvre-lès-Nancy, France; Division of Gastroenterology and Hepatology, McGill University Health Centre, Montreal, Quebec, Canada., Sands BE; The Dr Henry D Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Gaemers I; Tytgat Institute for Liver and Intestinal Research, Amsterdam UMC, Amsterdam, Netherlands., Westfall M; Inotiv, Nashville, TN, USA., Terry AQ; Sorriso Pharmaceuticals, Sandy, UT, USA; Magnify at CNSI, UCLA, Los Angeles, CA, USA., Roberts KJ; Sorriso Pharmaceuticals, Sandy, UT, USA; Magnify at CNSI, UCLA, Los Angeles, CA, USA., Barbat S; Sorriso Pharmaceuticals, Sandy, UT, USA., Wedel P; Sorriso Pharmaceuticals, Sandy, UT, USA., Benson JM; Sorriso Pharmaceuticals, Sandy, UT, USA., Sattler C; Sorriso Pharmaceuticals, Sandy, UT, USA.
Source: The lancet. Gastroenterology & hepatology [Lancet Gastroenterol Hepatol] 2026 Jan; Vol. 11 (1), pp. 34-45. Date of Electronic Publication: 2025 Nov 13.
Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase I; Multicenter Study
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101690683 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2468-1253 (Electronic) NLM ISO Abbreviation: Lancet Gastroenterol Hepatol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Safety and pharmacokinetics of SOR102, an oral bispecific inhibitor of TNF and interleukin-23 in healthy participants and patients with ulcerative colitis: a first-in-human, double-blind, randomised, placebo-controlled, phase 1 trial.
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  Data: <searchLink fieldCode="AU" term="%22Jairath+V%22">Jairath V</searchLink>; Division of Gastroenterology, Department of Medicine, Western University, London, ON, Canada; Department of Epidemiology and Biostatistics, Western University, London, ON, Canada. Electronic address: vjairath@uwo.ca.<br /><searchLink fieldCode="AU" term="%22Danese+S%22">Danese S</searchLink>; Department of Gastroenterology and Endoscopy, IRCCS Ospedale San Raffaele and University Vita-Salute San Raffaele, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22D'Haens+GR%22">D'Haens GR</searchLink>; Department of Gastroenterology and Hepatology, Amsterdam University Medical Centre, Academic Medical Centre, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Feagan+BG%22">Feagan BG</searchLink>; Division of Gastroenterology, Department of Medicine, Western University, London, ON, Canada; Department of Epidemiology and Biostatistics, Western University, London, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Peyrin-Biroulet+L%22">Peyrin-Biroulet L</searchLink>; Department of Gastroenterology, CHRU Nancy, INSERM NGERE, Université de Lorraine, Vandœuvre-lès-Nancy, France; Division of Gastroenterology and Hepatology, McGill University Health Centre, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Sands+BE%22">Sands BE</searchLink>; The Dr Henry D Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Gaemers+I%22">Gaemers I</searchLink>; Tytgat Institute for Liver and Intestinal Research, Amsterdam UMC, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Westfall+M%22">Westfall M</searchLink>; Inotiv, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Terry+AQ%22">Terry AQ</searchLink>; Sorriso Pharmaceuticals, Sandy, UT, USA; Magnify at CNSI, UCLA, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Roberts+KJ%22">Roberts KJ</searchLink>; Sorriso Pharmaceuticals, Sandy, UT, USA; Magnify at CNSI, UCLA, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Barbat+S%22">Barbat S</searchLink>; Sorriso Pharmaceuticals, Sandy, UT, USA.<br /><searchLink fieldCode="AU" term="%22Wedel+P%22">Wedel P</searchLink>; Sorriso Pharmaceuticals, Sandy, UT, USA.<br /><searchLink fieldCode="AU" term="%22Benson+JM%22">Benson JM</searchLink>; Sorriso Pharmaceuticals, Sandy, UT, USA.<br /><searchLink fieldCode="AU" term="%22Sattler+C%22">Sattler C</searchLink>; Sorriso Pharmaceuticals, Sandy, UT, USA.
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  Data: <searchLink fieldCode="JN" term="%22101690683%22">The lancet. Gastroenterology & hepatology</searchLink> [Lancet Gastroenterol Hepatol] 2026 Jan; Vol. 11 (1), pp. 34-45. <i>Date of Electronic Publication: </i>2025 Nov 13.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+B%2EV%22">Elsevier B.V </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>101690683 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2468-1253 (Electronic) <i>NLM ISO Abbreviation: </i>Lancet Gastroenterol Hepatol <i>Subsets: </i>MEDLINE
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