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USP22 drives tumor immune evasion and checkpoint blockade resistance through EZH2-mediated epigenetic silencing of MHC-I.

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Title: USP22 drives tumor immune evasion and checkpoint blockade resistance through EZH2-mediated epigenetic silencing of MHC-I.
Authors: Liu K; Department of Pathology, Robert H. Lurie Comprehensive Cancer Center and Center for Human Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Iyer R; Department of Pathology, Robert H. Lurie Comprehensive Cancer Center and Center for Human Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Li Y; Department of Oncology, 920th Hospital of Joint Logistics Support Force, Kunming, China., Zhu J; Department of Oncology, 920th Hospital of Joint Logistics Support Force, Kunming, China., Cai Z; Department of Pathology, Robert H. Lurie Comprehensive Cancer Center and Center for Human Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Wei J; Center of Metabolic Disease Research, Department of Cardiovascular Sciences, Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania, USA., Cheng Y; Department of Pathology, Robert H. Lurie Comprehensive Cancer Center and Center for Human Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Tang AY; Department of Pathology, Robert H. Lurie Comprehensive Cancer Center and Center for Human Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Wang H; Department of Pathology, Robert H. Lurie Comprehensive Cancer Center and Center for Human Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Gao Q; Department of Pathology, Robert H. Lurie Comprehensive Cancer Center and Center for Human Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Mani NL; Department of Pathology, Robert H. Lurie Comprehensive Cancer Center and Center for Human Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Marx N; Department of Pathology, Robert H. Lurie Comprehensive Cancer Center and Center for Human Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Gao B; Department of Pathology, Robert H. Lurie Comprehensive Cancer Center and Center for Human Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Watterson DM; Department of Pharmacology., Khan SA; Division of Breast Surgery, Robert H. Lurie Comprehensive Cancer Center., Gradishar WJ; Division of Hematology/Oncology, Department of Medicine, and., Liu H; Department of Pharmacology.; Department of Medicine, Division of Hematology and Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Fang D; Department of Pathology, Robert H. Lurie Comprehensive Cancer Center and Center for Human Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Source: The Journal of clinical investigation [J Clin Invest] 2025 Nov 18; Vol. 136 (1). Date of Electronic Publication: 2025 Nov 18 (Print Publication: 2026).
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: eCollection Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: USP22 drives tumor immune evasion and checkpoint blockade resistance through EZH2-mediated epigenetic silencing of MHC-I.
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  Data: <searchLink fieldCode="AU" term="%22Liu+K%22">Liu K</searchLink>; Department of Pathology, Robert H. Lurie Comprehensive Cancer Center and Center for Human Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Iyer+R%22">Iyer R</searchLink>; Department of Pathology, Robert H. Lurie Comprehensive Cancer Center and Center for Human Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Department of Oncology, 920th Hospital of Joint Logistics Support Force, Kunming, China.<br /><searchLink fieldCode="AU" term="%22Zhu+J%22">Zhu J</searchLink>; Department of Oncology, 920th Hospital of Joint Logistics Support Force, Kunming, China.<br /><searchLink fieldCode="AU" term="%22Cai+Z%22">Cai Z</searchLink>; Department of Pathology, Robert H. Lurie Comprehensive Cancer Center and Center for Human Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Wei+J%22">Wei J</searchLink>; Center of Metabolic Disease Research, Department of Cardiovascular Sciences, Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Cheng+Y%22">Cheng Y</searchLink>; Department of Pathology, Robert H. Lurie Comprehensive Cancer Center and Center for Human Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Tang+AY%22">Tang AY</searchLink>; Department of Pathology, Robert H. Lurie Comprehensive Cancer Center and Center for Human Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Department of Pathology, Robert H. Lurie Comprehensive Cancer Center and Center for Human Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Gao+Q%22">Gao Q</searchLink>; Department of Pathology, Robert H. Lurie Comprehensive Cancer Center and Center for Human Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Mani+NL%22">Mani NL</searchLink>; Department of Pathology, Robert H. Lurie Comprehensive Cancer Center and Center for Human Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Marx+N%22">Marx N</searchLink>; Department of Pathology, Robert H. Lurie Comprehensive Cancer Center and Center for Human Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Gao+B%22">Gao B</searchLink>; Department of Pathology, Robert H. Lurie Comprehensive Cancer Center and Center for Human Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Watterson+DM%22">Watterson DM</searchLink>; Department of Pharmacology.<br /><searchLink fieldCode="AU" term="%22Khan+SA%22">Khan SA</searchLink>; Division of Breast Surgery, Robert H. Lurie Comprehensive Cancer Center.<br /><searchLink fieldCode="AU" term="%22Gradishar+WJ%22">Gradishar WJ</searchLink>; Division of Hematology/Oncology, Department of Medicine, and.<br /><searchLink fieldCode="AU" term="%22Liu+H%22">Liu H</searchLink>; Department of Pharmacology.; Department of Medicine, Division of Hematology and Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Fang+D%22">Fang D</searchLink>; Department of Pathology, Robert H. Lurie Comprehensive Cancer Center and Center for Human Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
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  Data: <searchLink fieldCode="JN" term="%227802877%22">The Journal of clinical investigation</searchLink> [J Clin Invest] 2025 Nov 18; Vol. 136 (1). <i>Date of Electronic Publication: </i>2025 Nov 18 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Society+for+Clinical+Investigation%22">American Society for Clinical Investigation </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>7802877 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1558-8238 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200219738%22">00219738 </searchLink><i>NLM ISO Abbreviation: </i>J Clin Invest <i>Subsets: </i>MEDLINE
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        Value: 10.1172/JCI193162
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        Text: English
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      – TitleFull: USP22 drives tumor immune evasion and checkpoint blockade resistance through EZH2-mediated epigenetic silencing of MHC-I.
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