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Coronaviral nsp6 hijacks ERAD machinery to facilitate lipolysis and supply membrane components for DMV growth.

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Title: Coronaviral nsp6 hijacks ERAD machinery to facilitate lipolysis and supply membrane components for DMV growth.
Authors: Liu SR; Key Laboratory of Tropical Disease Control of Ministry of Education, Institute of Human Virology, Department of Pathogen Biology and Biosecurity, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, China.; Guangzhou National Laboratory, Guangzhou International Bio-Island, Guangzhou, China.; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China., Zhou Y; Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, China., Li J; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China., Wang Z; Guangzhou National Laboratory, Guangzhou International Bio-Island, Guangzhou, China., Ye Y; Centre for Infection and Immunity Study (CIIS), School of Medicine, Shenzhen Campus of Sun Yat-Sen University, Shenzhen, Guangdong, China., Miao J; Centre for Infection and Immunity Study (CIIS), School of Medicine, Shenzhen Campus of Sun Yat-Sen University, Shenzhen, Guangdong, China., Shi K; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China., Zheng B; Key Laboratory of Tropical Disease Control of Ministry of Education, Institute of Human Virology, Department of Pathogen Biology and Biosecurity, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, China.; Guangzhou National Laboratory, Guangzhou International Bio-Island, Guangzhou, China., Ding B; Guangzhou National Laboratory, Guangzhou International Bio-Island, Guangzhou, China.; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China., Pan J; Centre for Infection and Immunity Study (CIIS), School of Medicine, Shenzhen Campus of Sun Yat-Sen University, Shenzhen, Guangdong, China., Li CM; Centre for Infection and Immunity Study (CIIS), School of Medicine, Shenzhen Campus of Sun Yat-Sen University, Shenzhen, Guangdong, China., Li Y; Key Laboratory of Tropical Disease Control of Ministry of Education, Institute of Human Virology, Department of Pathogen Biology and Biosecurity, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, China., Hou P; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China. houpp@mail.sysu.edu.cn., Guo D; Key Laboratory of Tropical Disease Control of Ministry of Education, Institute of Human Virology, Department of Pathogen Biology and Biosecurity, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, China. guo_deyin@gzlab.ac.cn.; Guangzhou National Laboratory, Guangzhou International Bio-Island, Guangzhou, China. guo_deyin@gzlab.ac.cn.; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China. guo_deyin@gzlab.ac.cn.
Source: Nature communications [Nat Commun] 2025 Nov 18; Vol. 16 (1), pp. 10094. Date of Electronic Publication: 2025 Nov 18.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Coronaviral nsp6 hijacks ERAD machinery to facilitate lipolysis and supply membrane components for DMV growth.
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  Data: <searchLink fieldCode="AU" term="%22Liu+SR%22">Liu SR</searchLink>; Key Laboratory of Tropical Disease Control of Ministry of Education, Institute of Human Virology, Department of Pathogen Biology and Biosecurity, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, China.; Guangzhou National Laboratory, Guangzhou International Bio-Island, Guangzhou, China.; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Zhou+Y%22">Zhou Y</searchLink>; Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Guangzhou National Laboratory, Guangzhou International Bio-Island, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Ye+Y%22">Ye Y</searchLink>; Centre for Infection and Immunity Study (CIIS), School of Medicine, Shenzhen Campus of Sun Yat-Sen University, Shenzhen, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Miao+J%22">Miao J</searchLink>; Centre for Infection and Immunity Study (CIIS), School of Medicine, Shenzhen Campus of Sun Yat-Sen University, Shenzhen, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Shi+K%22">Shi K</searchLink>; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Zheng+B%22">Zheng B</searchLink>; Key Laboratory of Tropical Disease Control of Ministry of Education, Institute of Human Virology, Department of Pathogen Biology and Biosecurity, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, China.; Guangzhou National Laboratory, Guangzhou International Bio-Island, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Ding+B%22">Ding B</searchLink>; Guangzhou National Laboratory, Guangzhou International Bio-Island, Guangzhou, China.; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Pan+J%22">Pan J</searchLink>; Centre for Infection and Immunity Study (CIIS), School of Medicine, Shenzhen Campus of Sun Yat-Sen University, Shenzhen, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Li+CM%22">Li CM</searchLink>; Centre for Infection and Immunity Study (CIIS), School of Medicine, Shenzhen Campus of Sun Yat-Sen University, Shenzhen, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Key Laboratory of Tropical Disease Control of Ministry of Education, Institute of Human Virology, Department of Pathogen Biology and Biosecurity, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Hou+P%22">Hou P</searchLink>; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China. houpp@mail.sysu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Guo+D%22">Guo D</searchLink>; Key Laboratory of Tropical Disease Control of Ministry of Education, Institute of Human Virology, Department of Pathogen Biology and Biosecurity, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, China. guo_deyin@gzlab.ac.cn.; Guangzhou National Laboratory, Guangzhou International Bio-Island, Guangzhou, China. guo_deyin@gzlab.ac.cn.; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China. guo_deyin@gzlab.ac.cn.
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