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Leveraging in vitro Tumor Cell Killing and Cytokine Release to Predict Cytokine Release Syndrome Associated with CD3 T-cell Bispecifics in Oncology: a Retrospective Analysis.

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Bibliographic Details
Title: Leveraging in vitro Tumor Cell Killing and Cytokine Release to Predict Cytokine Release Syndrome Associated with CD3 T-cell Bispecifics in Oncology: a Retrospective Analysis.
Authors: Lefèvre A; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, Basel, 4070, Switzerland. apolline.lefevre@roche.com.; Pharmacometrics & Systems Pharmacology, Department of Pharmaceutical Science. School of Pharmacy and Nutrition, University of Navarra, Pamplona, 31009, Spain. apolline.lefevre@roche.com., Parra-Guillen ZP; Pharmacometrics & Systems Pharmacology, Department of Pharmaceutical Science. School of Pharmacy and Nutrition, University of Navarra, Pamplona, 31009, Spain.; Navarra Institute for Health Research (IdiSNA), Pamplona, 31009, Spain., Trocóniz IF; Pharmacometrics & Systems Pharmacology, Department of Pharmaceutical Science. School of Pharmacy and Nutrition, University of Navarra, Pamplona, 31009, Spain.; Navarra Institute for Health Research (IdiSNA), Pamplona, 31009, Spain.; Institute of Data Science and Artificial Intelligence, DATAI, University of Navarra, Pamplona, 31009, Spain., Boetsch C; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, Basel, 4070, Switzerland., Frances N; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, Basel, 4070, Switzerland.
Source: The AAPS journal [AAPS J] 2025 Nov 18; Vol. 28 (1), pp. 20. Date of Electronic Publication: 2025 Nov 18.
Publication Type: Journal Article
Journal Info: Publisher: American Association of Pharmaceutical Scientists Country of Publication: United States NLM ID: 101223209 Publication Model: Electronic Cited Medium: Internet ISSN: 1550-7416 (Electronic) Linking ISSN: 15507416 NLM ISO Abbreviation: AAPS J Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1550-7416
DOI:10.1208/s12248-025-01177-9