Leveraging in vitro Tumor Cell Killing and Cytokine Release to Predict Cytokine Release Syndrome Associated with CD3 T-cell Bispecifics in Oncology: a Retrospective Analysis.
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| Title: | Leveraging in vitro Tumor Cell Killing and Cytokine Release to Predict Cytokine Release Syndrome Associated with CD3 T-cell Bispecifics in Oncology: a Retrospective Analysis. |
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| Authors: | Lefèvre A; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, Basel, 4070, Switzerland. apolline.lefevre@roche.com.; Pharmacometrics & Systems Pharmacology, Department of Pharmaceutical Science. School of Pharmacy and Nutrition, University of Navarra, Pamplona, 31009, Spain. apolline.lefevre@roche.com., Parra-Guillen ZP; Pharmacometrics & Systems Pharmacology, Department of Pharmaceutical Science. School of Pharmacy and Nutrition, University of Navarra, Pamplona, 31009, Spain.; Navarra Institute for Health Research (IdiSNA), Pamplona, 31009, Spain., Trocóniz IF; Pharmacometrics & Systems Pharmacology, Department of Pharmaceutical Science. School of Pharmacy and Nutrition, University of Navarra, Pamplona, 31009, Spain.; Navarra Institute for Health Research (IdiSNA), Pamplona, 31009, Spain.; Institute of Data Science and Artificial Intelligence, DATAI, University of Navarra, Pamplona, 31009, Spain., Boetsch C; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, Basel, 4070, Switzerland., Frances N; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, Basel, 4070, Switzerland. |
| Source: | The AAPS journal [AAPS J] 2025 Nov 18; Vol. 28 (1), pp. 20. Date of Electronic Publication: 2025 Nov 18. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association of Pharmaceutical Scientists Country of Publication: United States NLM ID: 101223209 Publication Model: Electronic Cited Medium: Internet ISSN: 1550-7416 (Electronic) Linking ISSN: 15507416 NLM ISO Abbreviation: AAPS J Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41254345 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Leveraging in vitro Tumor Cell Killing and Cytokine Release to Predict Cytokine Release Syndrome Associated with CD3 T-cell Bispecifics in Oncology: a Retrospective Analysis. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Lefèvre+A%22">Lefèvre A</searchLink>; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, Basel, 4070, Switzerland. apolline.lefevre@roche.com.; Pharmacometrics & Systems Pharmacology, Department of Pharmaceutical Science. School of Pharmacy and Nutrition, University of Navarra, Pamplona, 31009, Spain. apolline.lefevre@roche.com.<br /><searchLink fieldCode="AU" term="%22Parra-Guillen+ZP%22">Parra-Guillen ZP</searchLink>; Pharmacometrics & Systems Pharmacology, Department of Pharmaceutical Science. School of Pharmacy and Nutrition, University of Navarra, Pamplona, 31009, Spain.; Navarra Institute for Health Research (IdiSNA), Pamplona, 31009, Spain.<br /><searchLink fieldCode="AU" term="%22Trocóniz+IF%22">Trocóniz IF</searchLink>; Pharmacometrics & Systems Pharmacology, Department of Pharmaceutical Science. School of Pharmacy and Nutrition, University of Navarra, Pamplona, 31009, Spain.; Navarra Institute for Health Research (IdiSNA), Pamplona, 31009, Spain.; Institute of Data Science and Artificial Intelligence, DATAI, University of Navarra, Pamplona, 31009, Spain.<br /><searchLink fieldCode="AU" term="%22Boetsch+C%22">Boetsch C</searchLink>; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, Basel, 4070, Switzerland.<br /><searchLink fieldCode="AU" term="%22Frances+N%22">Frances N</searchLink>; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, Basel, 4070, Switzerland. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101223209%22">The AAPS journal</searchLink> [AAPS J] 2025 Nov 18; Vol. 28 (1), pp. 20. <i>Date of Electronic Publication: </i>2025 Nov 18. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+of+Pharmaceutical+Scientists%22">American Association of Pharmaceutical Scientists </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101223209 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1550-7416 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215507416%22">15507416 </searchLink><i>NLM ISO Abbreviation: </i>AAPS J <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41254345 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1208/s12248-025-01177-9 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 20 Titles: – TitleFull: Leveraging in vitro Tumor Cell Killing and Cytokine Release to Predict Cytokine Release Syndrome Associated with CD3 T-cell Bispecifics in Oncology: a Retrospective Analysis. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Lefèvre A – PersonEntity: Name: NameFull: Parra-Guillen ZP – PersonEntity: Name: NameFull: Trocóniz IF – PersonEntity: Name: NameFull: Boetsch C – PersonEntity: Name: NameFull: Frances N IsPartOfRelationships: – BibEntity: Dates: – D: 18 M: 11 Text: 2025 Nov 18 Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 1550-7416 Numbering: – Type: volume Value: 28 – Type: issue Value: 1 Titles: – TitleFull: The AAPS journal Type: main |
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