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Inhibiting ferroptosis enhances ex vivo expansion of human haematopoietic stem cells.

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Title: Inhibiting ferroptosis enhances ex vivo expansion of human haematopoietic stem cells.
Authors: Della Volpe L; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Howard Hughes Medical Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Lee AJ; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Howard Hughes Medical Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Antoszewski M; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Howard Hughes Medical Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Deik AA; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Safina KR; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Gao T; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Howard Hughes Medical Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Guo CJ; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Howard Hughes Medical Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ye T; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Howard Hughes Medical Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Lyu P; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Howard Hughes Medical Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Martin-Rufino JD; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Howard Hughes Medical Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Castano N; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Howard Hughes Medical Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Good J; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Molina-Aponte Y; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Howard Hughes Medical Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Zhao J; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Howard Hughes Medical Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Faculty of Pharmaceutical Sciences, Shenzhen University of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China., Clish CB; Broad Institute of MIT and Harvard, Cambridge, MA, USA., van Galen P; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Ludwig Center at Harvard, Harvard Medical School, Boston, MA, USA.; Harvard Stem Cell Institute, Cambridge, MA, USA., Sankaran VG; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA. sankaran@broadinstitute.org.; Howard Hughes Medical Institute, Boston, MA, USA. sankaran@broadinstitute.org.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. sankaran@broadinstitute.org.; Harvard Stem Cell Institute, Cambridge, MA, USA. sankaran@broadinstitute.org.
Source: Nature cell biology [Nat Cell Biol] 2025 Dec; Vol. 27 (12), pp. 2214-2224. Date of Electronic Publication: 2025 Nov 18.
Publication Type: Journal Article
Journal Info: Publisher: Macmillan Magazines Ltd Country of Publication: England NLM ID: 100890575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4679 (Electronic) Linking ISSN: 14657392 NLM ISO Abbreviation: Nat Cell Biol Subsets: MEDLINE
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  Data: Inhibiting ferroptosis enhances ex vivo expansion of human haematopoietic stem cells.
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  Data: <searchLink fieldCode="AU" term="%22Della+Volpe+L%22">Della Volpe L</searchLink>; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Howard Hughes Medical Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lee+AJ%22">Lee AJ</searchLink>; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Howard Hughes Medical Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Antoszewski+M%22">Antoszewski M</searchLink>; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Howard Hughes Medical Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Deik+AA%22">Deik AA</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Safina+KR%22">Safina KR</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Gao+T%22">Gao T</searchLink>; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Howard Hughes Medical Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Guo+CJ%22">Guo CJ</searchLink>; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; 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Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Zhao+J%22">Zhao J</searchLink>; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Howard Hughes Medical Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Faculty of Pharmaceutical Sciences, Shenzhen University of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Clish+CB%22">Clish CB</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22van+Galen+P%22">van Galen P</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Ludwig Center at Harvard, Harvard Medical School, Boston, MA, USA.; Harvard Stem Cell Institute, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Sankaran+VG%22">Sankaran VG</searchLink>; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA. sankaran@broadinstitute.org.; Howard Hughes Medical Institute, Boston, MA, USA. sankaran@broadinstitute.org.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. sankaran@broadinstitute.org.; Harvard Stem Cell Institute, Cambridge, MA, USA. sankaran@broadinstitute.org.
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  Data: <searchLink fieldCode="JN" term="%22100890575%22">Nature cell biology</searchLink> [Nat Cell Biol] 2025 Dec; Vol. 27 (12), pp. 2214-2224. <i>Date of Electronic Publication: </i>2025 Nov 18.
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