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IL-15 complex enhances therapeutic efficacy of anti-PD-L1 in a T cell-dependent and NK cell-independent manner in a murine model of pancreatic ductal adenocarcinoma.

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Title: IL-15 complex enhances therapeutic efficacy of anti-PD-L1 in a T cell-dependent and NK cell-independent manner in a murine model of pancreatic ductal adenocarcinoma.
Authors: Burrack AL; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, United States.; Center for Immunology, University of Minnesota, University of Minnesota, Minneapolis, MN, United States., Tsai AK; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, United States.; Center for Immunology, University of Minnesota, University of Minnesota, Minneapolis, MN, United States.; Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, MN, United States., Ellefson MA; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, United States.; Center for Immunology, University of Minnesota, University of Minnesota, Minneapolis, MN, United States., Schmiechen ZC; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, United States.; Center for Immunology, University of Minnesota, University of Minnesota, Minneapolis, MN, United States., Larsen BM; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, United States.; Center for Immunology, University of Minnesota, University of Minnesota, Minneapolis, MN, United States., Burrack KS; Center for Immunology, University of Minnesota, University of Minnesota, Minneapolis, MN, United States.; Department of Medicine, University of Minnesota, Minneapolis, MN, United States.; Division of Infectious Disease, Hennepin Healthcare Research Institute, Minneapolis, MN, United States., Stromnes IM; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, United States.; Center for Immunology, University of Minnesota, University of Minnesota, Minneapolis, MN, United States.; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, United States.; Center for Genome Engineering, University of Minnesota, Minneapolis, MN, United States.
Source: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2025 Dec 01; Vol. 214 (12), pp. 3228-3237.
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 2985117R Publication Model: Print Cited Medium: Internet ISSN: 1550-6606 (Electronic) Linking ISSN: 00221767 NLM ISO Abbreviation: J Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: IL-15 complex enhances therapeutic efficacy of anti-PD-L1 in a T cell-dependent and NK cell-independent manner in a murine model of pancreatic ductal adenocarcinoma.
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  Data: <searchLink fieldCode="AU" term="%22Burrack+AL%22">Burrack AL</searchLink>; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, United States.; Center for Immunology, University of Minnesota, University of Minnesota, Minneapolis, MN, United States.<br /><searchLink fieldCode="AU" term="%22Tsai+AK%22">Tsai AK</searchLink>; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, United States.; Center for Immunology, University of Minnesota, University of Minnesota, Minneapolis, MN, United States.; Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, MN, United States.<br /><searchLink fieldCode="AU" term="%22Ellefson+MA%22">Ellefson MA</searchLink>; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, United States.; Center for Immunology, University of Minnesota, University of Minnesota, Minneapolis, MN, United States.<br /><searchLink fieldCode="AU" term="%22Schmiechen+ZC%22">Schmiechen ZC</searchLink>; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, United States.; Center for Immunology, University of Minnesota, University of Minnesota, Minneapolis, MN, United States.<br /><searchLink fieldCode="AU" term="%22Larsen+BM%22">Larsen BM</searchLink>; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, United States.; Center for Immunology, University of Minnesota, University of Minnesota, Minneapolis, MN, United States.<br /><searchLink fieldCode="AU" term="%22Burrack+KS%22">Burrack KS</searchLink>; Center for Immunology, University of Minnesota, University of Minnesota, Minneapolis, MN, United States.; Department of Medicine, University of Minnesota, Minneapolis, MN, United States.; Division of Infectious Disease, Hennepin Healthcare Research Institute, Minneapolis, MN, United States.<br /><searchLink fieldCode="AU" term="%22Stromnes+IM%22">Stromnes IM</searchLink>; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, United States.; Center for Immunology, University of Minnesota, University of Minnesota, Minneapolis, MN, United States.; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, United States.; Center for Genome Engineering, University of Minnesota, Minneapolis, MN, United States.
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  Data: <searchLink fieldCode="JN" term="%222985117R%22">Journal of immunology (Baltimore, Md. : 1950)</searchLink> [J Immunol] 2025 Dec 01; Vol. 214 (12), pp. 3228-3237.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Oxford+University+Press%22">Oxford University Press </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>2985117R <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1550-6606 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200221767%22">00221767 </searchLink><i>NLM ISO Abbreviation: </i>J Immunol <i>Subsets: </i>MEDLINE
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        Value: 10.1093/jimmun/vkaf314
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      – Code: eng
        Text: English
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      – TitleFull: IL-15 complex enhances therapeutic efficacy of anti-PD-L1 in a T cell-dependent and NK cell-independent manner in a murine model of pancreatic ductal adenocarcinoma.
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              Text: 2025 Dec 01
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