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Age-related microbiome metabolites alter RNA splicing and chromatin accessibility in the brain.

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Title: Age-related microbiome metabolites alter RNA splicing and chromatin accessibility in the brain.
Authors: Chakraborty M; Department of Genetics, Stanford University, Stanford, CA, USA., Shi SM; Department of Chemistry, Stanford University, Stanford, CA, USA.; Stanford Chemistry, Engineering and Medicine for Human Health (ChEM-H), Stanford University, Stanford, CA, USA.; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.; Wu Tsai Neurosciences Institute, Stanford University School of Medicine, Stanford, CA, USA., Porter IE; Department of Genetics, Stanford University, Stanford, CA, USA., Richard DJ; Department of Genetics, Stanford University, Stanford, CA, USA., Marinov GK; Department of Genetics, Stanford University, Stanford, CA, USA., Moore AA; Department of Medicine, Divisions of Hematology and Blood & Marrow Transplantation, Stanford University, Stanford, CA, USA., Blum JLE; Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Natarajan A; Department of Medicine, Divisions of Hematology and Blood & Marrow Transplantation, Stanford University, Stanford, CA, USA., Jahng JW; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA.; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA., Wu JC; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA.; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA., Lu SX; Department of Medicine, Divisions of Hematology and Blood & Marrow Transplantation, Stanford University, Stanford, CA, USA., Davidson SM; Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Greenleaf WJ; Department of Genetics, Stanford University, Stanford, CA, USA., Saw NL; Stanford Behavioral and Functional Neuroscience Laboratory, Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA., Shamloo M; Stanford Behavioral and Functional Neuroscience Laboratory, Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.; Department of Neurosurgery, School of Medicine, Stanford University, Stanford, CA, USA., Brunet A; Department of Genetics, Stanford University, Stanford, CA, USA.; Wu Tsai Neurosciences Institute, Stanford University School of Medicine, Stanford, CA, USA.; Glenn Center for the Biology of Aging, Stanford University, Stanford, CA, USA.; The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, CA, USA., Wyss-Coray T; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.; Wu Tsai Neurosciences Institute, Stanford University School of Medicine, Stanford, CA, USA.; The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, CA, USA., Bhatt AS; Department of Genetics, Stanford University, Stanford, CA, USA.; Department of Medicine, Divisions of Hematology and Blood & Marrow Transplantation, Stanford University, Stanford, CA, USA.; The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, CA, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Nov 02. Date of Electronic Publication: 2025 Nov 02.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Age-related microbiome metabolites alter RNA splicing and chromatin accessibility in the brain.
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  Data: <searchLink fieldCode="AU" term="%22Chakraborty+M%22">Chakraborty M</searchLink>; Department of Genetics, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Shi+SM%22">Shi SM</searchLink>; Department of Chemistry, Stanford University, Stanford, CA, USA.; Stanford Chemistry, Engineering and Medicine for Human Health (ChEM-H), Stanford University, Stanford, CA, USA.; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.; Wu Tsai Neurosciences Institute, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Porter+IE%22">Porter IE</searchLink>; Department of Genetics, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Richard+DJ%22">Richard DJ</searchLink>; Department of Genetics, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Marinov+GK%22">Marinov GK</searchLink>; Department of Genetics, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Moore+AA%22">Moore AA</searchLink>; Department of Medicine, Divisions of Hematology and Blood & Marrow Transplantation, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Blum+JLE%22">Blum JLE</searchLink>; Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Natarajan+A%22">Natarajan A</searchLink>; Department of Medicine, Divisions of Hematology and Blood & Marrow Transplantation, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Jahng+JW%22">Jahng JW</searchLink>; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA.; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wu+JC%22">Wu JC</searchLink>; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA.; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lu+SX%22">Lu SX</searchLink>; Department of Medicine, Divisions of Hematology and Blood & Marrow Transplantation, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Davidson+SM%22">Davidson SM</searchLink>; Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Greenleaf+WJ%22">Greenleaf WJ</searchLink>; Department of Genetics, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Saw+NL%22">Saw NL</searchLink>; Stanford Behavioral and Functional Neuroscience Laboratory, Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Shamloo+M%22">Shamloo M</searchLink>; Stanford Behavioral and Functional Neuroscience Laboratory, Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.; Department of Neurosurgery, School of Medicine, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Brunet+A%22">Brunet A</searchLink>; Department of Genetics, Stanford University, Stanford, CA, USA.; Wu Tsai Neurosciences Institute, Stanford University School of Medicine, Stanford, CA, USA.; Glenn Center for the Biology of Aging, Stanford University, Stanford, CA, USA.; The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wyss-Coray+T%22">Wyss-Coray T</searchLink>; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.; Wu Tsai Neurosciences Institute, Stanford University School of Medicine, Stanford, CA, USA.; The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Bhatt+AS%22">Bhatt AS</searchLink>; Department of Genetics, Stanford University, Stanford, CA, USA.; Department of Medicine, Divisions of Hematology and Blood & Marrow Transplantation, Stanford University, Stanford, CA, USA.; The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, CA, USA.
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        Value: 10.1101/2025.10.03.680371
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