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Low Dose GLP-1 Therapy Attenuates Pathological Cardiac and Hepatic Remodelling in HFpEF Independent of Weight Loss.

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Title: Low Dose GLP-1 Therapy Attenuates Pathological Cardiac and Hepatic Remodelling in HFpEF Independent of Weight Loss.
Authors: Elbatreek MH; Department of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA.; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt., Li Z; School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China., Yu X; School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China., Gehred ND; Departments of Anesthesiology & Perioperative Medicine, Medicine and Physiology, Molecular Biology Institute, David Geffen School of Medicine at University of California, Los Angeles, CA., Gromova T; Departments of Anesthesiology & Perioperative Medicine, Medicine and Physiology, Molecular Biology Institute, David Geffen School of Medicine at University of California, Los Angeles, CA., Chen J; Gordian Biotechnology, South San Francisco, CA., Muraoka N; Gordian Biotechnology, South San Francisco, CA., Jensen M; Gordian Biotechnology, South San Francisco, CA., Kartha V; Gordian Biotechnology, South San Francisco, CA., Carrico C; Gordian Biotechnology, South San Francisco, CA., Allerton TD; Vascular Metabolism Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA., Bowdish ME; Department of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA., Chikwe J; Department of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA., Shah SJ; Northwestern University Medicine, Feinberg School of Medicine, Chicago, IL., Woulfe KC; Department of Medicine, Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora., McKinsey TA; Department of Medicine, Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora., Yoo E; Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA., Polhemus DJ; Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA., Vondriska TM; Departments of Anesthesiology & Perioperative Medicine, Medicine and Physiology, Molecular Biology Institute, David Geffen School of Medicine at University of California, Los Angeles, CA., Goodchild TT; Department of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA., Lefer DJ; Department of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Sep 29. Date of Electronic Publication: 2025 Sep 29.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Low Dose GLP-1 Therapy Attenuates Pathological Cardiac and Hepatic Remodelling in HFpEF Independent of Weight Loss.
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  Data: <searchLink fieldCode="AU" term="%22Elbatreek+MH%22">Elbatreek MH</searchLink>; Department of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA.; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Yu+X%22">Yu X</searchLink>; School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Gehred+ND%22">Gehred ND</searchLink>; Departments of Anesthesiology & Perioperative Medicine, Medicine and Physiology, Molecular Biology Institute, David Geffen School of Medicine at University of California, Los Angeles, CA.<br /><searchLink fieldCode="AU" term="%22Gromova+T%22">Gromova T</searchLink>; Departments of Anesthesiology & Perioperative Medicine, Medicine and Physiology, Molecular Biology Institute, David Geffen School of Medicine at University of California, Los Angeles, CA.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Gordian Biotechnology, South San Francisco, CA.<br /><searchLink fieldCode="AU" term="%22Muraoka+N%22">Muraoka N</searchLink>; Gordian Biotechnology, South San Francisco, CA.<br /><searchLink fieldCode="AU" term="%22Jensen+M%22">Jensen M</searchLink>; Gordian Biotechnology, South San Francisco, CA.<br /><searchLink fieldCode="AU" term="%22Kartha+V%22">Kartha V</searchLink>; Gordian Biotechnology, South San Francisco, CA.<br /><searchLink fieldCode="AU" term="%22Carrico+C%22">Carrico C</searchLink>; Gordian Biotechnology, South San Francisco, CA.<br /><searchLink fieldCode="AU" term="%22Allerton+TD%22">Allerton TD</searchLink>; Vascular Metabolism Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA.<br /><searchLink fieldCode="AU" term="%22Bowdish+ME%22">Bowdish ME</searchLink>; Department of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA.<br /><searchLink fieldCode="AU" term="%22Chikwe+J%22">Chikwe J</searchLink>; Department of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA.<br /><searchLink fieldCode="AU" term="%22Shah+SJ%22">Shah SJ</searchLink>; Northwestern University Medicine, Feinberg School of Medicine, Chicago, IL.<br /><searchLink fieldCode="AU" term="%22Woulfe+KC%22">Woulfe KC</searchLink>; Department of Medicine, Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora.<br /><searchLink fieldCode="AU" term="%22McKinsey+TA%22">McKinsey TA</searchLink>; Department of Medicine, Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora.<br /><searchLink fieldCode="AU" term="%22Yoo+E%22">Yoo E</searchLink>; Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Polhemus+DJ%22">Polhemus DJ</searchLink>; Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Vondriska+TM%22">Vondriska TM</searchLink>; Departments of Anesthesiology & Perioperative Medicine, Medicine and Physiology, Molecular Biology Institute, David Geffen School of Medicine at University of California, Los Angeles, CA.<br /><searchLink fieldCode="AU" term="%22Goodchild+TT%22">Goodchild TT</searchLink>; Department of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA.<br /><searchLink fieldCode="AU" term="%22Lefer+DJ%22">Lefer DJ</searchLink>; Department of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA.
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