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Identifying a novel Mecp2-mediated epigenetic mechanism controlling Lonp1 in the hippocampus and its disruption by aging.

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Title: Identifying a novel Mecp2-mediated epigenetic mechanism controlling Lonp1 in the hippocampus and its disruption by aging.
Authors: Llanquinao-Sandoval J; Laboratory of Neurobiology of Aging, Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Huechuraba, 8580702, Santiago, Chile.; Facultad de Ciencias, Universidad San Sebastián, Lota 2465, 7510157, Santiago, Chile.; Laboratory of Neuroendocrinology and Metabolism, Centro de Biología Celular y Biomedicina (CEBICEM), Facultad de Ciencias, Universidad San Sebastián, Santiago, Chile.; Translational Medicine Laboratory, Instituto Oncológico Fundación Arturo López Pérez, 7500691, Santiago, Chile., Cicali KA; Laboratory of Neurobiology of Aging, Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Huechuraba, 8580702, Santiago, Chile.; Facultad de Ciencias, Universidad San Sebastián, Lota 2465, 7510157, Santiago, Chile., Jara C; Laboratory of Neurobiology of Aging, Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Huechuraba, 8580702, Santiago, Chile.; Facultad de Salud y Ciencias Sociales, Universidad de Las Américas, 7500975, Santiago, Chile., Vigil-Vásquez C; Laboratory of Neurobiology of Aging, Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Huechuraba, 8580702, Santiago, Chile.; Facultad de Ciencias, Universidad San Sebastián, Lota 2465, 7510157, Santiago, Chile., Sjöberg-Herrera MK; School of Biological Sciences, Pontificia Universidad Católica de Chile, 8331150, Santiago, Chile., Ricca M; Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Avenida del Valle Norte 725, Huechuraba, 8580702, Santiago, Chile., Valenzuela S; Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Avenida del Valle Norte 725, Huechuraba, 8580702, Santiago, Chile.; Facultad de Medicina Veterinaria, Universidad San Sebastián, Bellavista 07, Recoleta, 8420524, Santiago, Chile., Loyola A; Facultad de Ciencias, Universidad San Sebastián, Lota 2465, 7510157, Santiago, Chile.; Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Avenida del Valle Norte 725, Huechuraba, 8580702, Santiago, Chile., Pinti M; Department of Life Sciences, University of Modena and Reggio Emilia, 41125, Modena, Italy., Schüller A; School of Biological Sciences, Pontificia Universidad Católica de Chile, 8331150, Santiago, Chile.; Institute for Biological and Medical Engineering, Pontificia Universidad Católica de Chile, 7820436, Santiago, Chile., Kerr B; Laboratory of Neuroendocrinology and Metabolism, Centro de Biología Celular y Biomedicina (CEBICEM), Facultad de Ciencias, Universidad San Sebastián, Santiago, Chile. Bredford.kerr@uss.cl., Tapia-Rojas C; Laboratory of Neurobiology of Aging, Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Huechuraba, 8580702, Santiago, Chile. cheril.tapia@uss.cl.; Facultad de Ciencias, Universidad San Sebastián, Lota 2465, 7510157, Santiago, Chile. cheril.tapia@uss.cl.
Source: Scientific reports [Sci Rep] 2025 Nov 19; Vol. 15 (1), pp. 40887. Date of Electronic Publication: 2025 Nov 19.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
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  Data: Identifying a novel Mecp2-mediated epigenetic mechanism controlling Lonp1 in the hippocampus and its disruption by aging.
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  Data: <searchLink fieldCode="AU" term="%22Llanquinao-Sandoval+J%22">Llanquinao-Sandoval J</searchLink>; Laboratory of Neurobiology of Aging, Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Huechuraba, 8580702, Santiago, Chile.; Facultad de Ciencias, Universidad San Sebastián, Lota 2465, 7510157, Santiago, Chile.; Laboratory of Neuroendocrinology and Metabolism, Centro de Biología Celular y Biomedicina (CEBICEM), Facultad de Ciencias, Universidad San Sebastián, Santiago, Chile.; Translational Medicine Laboratory, Instituto Oncológico Fundación Arturo López Pérez, 7500691, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Cicali+KA%22">Cicali KA</searchLink>; Laboratory of Neurobiology of Aging, Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Huechuraba, 8580702, Santiago, Chile.; Facultad de Ciencias, Universidad San Sebastián, Lota 2465, 7510157, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Jara+C%22">Jara C</searchLink>; Laboratory of Neurobiology of Aging, Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Huechuraba, 8580702, Santiago, Chile.; Facultad de Salud y Ciencias Sociales, Universidad de Las Américas, 7500975, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Vigil-Vásquez+C%22">Vigil-Vásquez C</searchLink>; Laboratory of Neurobiology of Aging, Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Huechuraba, 8580702, Santiago, Chile.; Facultad de Ciencias, Universidad San Sebastián, Lota 2465, 7510157, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Sjöberg-Herrera+MK%22">Sjöberg-Herrera MK</searchLink>; School of Biological Sciences, Pontificia Universidad Católica de Chile, 8331150, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Ricca+M%22">Ricca M</searchLink>; Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Avenida del Valle Norte 725, Huechuraba, 8580702, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Valenzuela+S%22">Valenzuela S</searchLink>; Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Avenida del Valle Norte 725, Huechuraba, 8580702, Santiago, Chile.; Facultad de Medicina Veterinaria, Universidad San Sebastián, Bellavista 07, Recoleta, 8420524, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Loyola+A%22">Loyola A</searchLink>; Facultad de Ciencias, Universidad San Sebastián, Lota 2465, 7510157, Santiago, Chile.; Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Avenida del Valle Norte 725, Huechuraba, 8580702, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Pinti+M%22">Pinti M</searchLink>; Department of Life Sciences, University of Modena and Reggio Emilia, 41125, Modena, Italy.<br /><searchLink fieldCode="AU" term="%22Schüller+A%22">Schüller A</searchLink>; School of Biological Sciences, Pontificia Universidad Católica de Chile, 8331150, Santiago, Chile.; Institute for Biological and Medical Engineering, Pontificia Universidad Católica de Chile, 7820436, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Kerr+B%22">Kerr B</searchLink>; Laboratory of Neuroendocrinology and Metabolism, Centro de Biología Celular y Biomedicina (CEBICEM), Facultad de Ciencias, Universidad San Sebastián, Santiago, Chile. Bredford.kerr@uss.cl.<br /><searchLink fieldCode="AU" term="%22Tapia-Rojas+C%22">Tapia-Rojas C</searchLink>; Laboratory of Neurobiology of Aging, Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Huechuraba, 8580702, Santiago, Chile. cheril.tapia@uss.cl.; Facultad de Ciencias, Universidad San Sebastián, Lota 2465, 7510157, Santiago, Chile. cheril.tapia@uss.cl.
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  Data: <searchLink fieldCode="JN" term="%22101563288%22">Scientific reports</searchLink> [Sci Rep] 2025 Nov 19; Vol. 15 (1), pp. 40887. <i>Date of Electronic Publication: </i>2025 Nov 19.
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