The Mac1 ADP-ribosylhydrolase is a therapeutic target for SARS-CoV-2.
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| Title: | The Mac1 ADP-ribosylhydrolase is a therapeutic target for SARS-CoV-2. |
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| Authors: | Suryawanshi RK; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, United States., Jaishankar P; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, United States., Correy GJ; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, United States., Rachman MM; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, United States., O'Leary PC; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, United States., Taha TY; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, United States.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, United States., Matsui Y; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, United States., Zapatero-Belinchón FJ; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, United States., McCavitt-Malvido M; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, United States., Doruk YU; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, United States., Stevens MGV; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, United States., Diolaiti ME; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, United States., Jogalekar MP; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, United States., Chen H; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, United States., Richards AL; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, United States.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, United States.; Data Science and Biotechnology Institute, Gladstone Institutes, San Francisco, United States., Kongpracha P; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, United States.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, United States.; Data Science and Biotechnology Institute, Gladstone Institutes, San Francisco, United States., Bali S; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, United States., Montano M; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, United States., Rosecrans J; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, United States., Matthay M; Data Science and Biotechnology Institute, Gladstone Institutes, San Francisco, United States., Togo T; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, United States., Gonciarz RL; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, United States., Gopalkrishnan S; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, United States., Neitz RJ; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, United States.; Small Molecule Discovery Center, University of California San Francisco, San Francisco, United States., Krogan NJ; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, United States.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, United States.; Data Science and Biotechnology Institute, Gladstone Institutes, San Francisco, United States., Swaney DL; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, United States.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, United States.; Data Science and Biotechnology Institute, Gladstone Institutes, San Francisco, United States., Shoichet BK; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, United States., Ott M; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, United States.; Department of Medicine, University of California San Francisco, San Francisco, United States.; Chan Zuckerberg Biohub- San Francisco, San Francisco, San Francisco, United States., Renslo AR; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, United States., Ashworth A; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, United States., Fraser JS; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, United States. |
| Source: | ELife [Elife] 2025 Nov 19; Vol. 14. Date of Electronic Publication: 2025 Nov 19. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41258893 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: The Mac1 ADP-ribosylhydrolase is a therapeutic target for SARS-CoV-2. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Suryawanshi+RK%22">Suryawanshi RK</searchLink>; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Jaishankar+P%22">Jaishankar P</searchLink>; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Correy+GJ%22">Correy GJ</searchLink>; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Rachman+MM%22">Rachman MM</searchLink>; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22O'Leary+PC%22">O'Leary PC</searchLink>; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Taha+TY%22">Taha TY</searchLink>; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, United States.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Matsui+Y%22">Matsui Y</searchLink>; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Zapatero-Belinchón+FJ%22">Zapatero-Belinchón FJ</searchLink>; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22McCavitt-Malvido+M%22">McCavitt-Malvido M</searchLink>; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Doruk+YU%22">Doruk YU</searchLink>; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Stevens+MGV%22">Stevens MGV</searchLink>; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Diolaiti+ME%22">Diolaiti ME</searchLink>; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Jogalekar+MP%22">Jogalekar MP</searchLink>; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Chen+H%22">Chen H</searchLink>; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Richards+AL%22">Richards AL</searchLink>; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, United States.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, United States.; Data Science and Biotechnology Institute, Gladstone Institutes, San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Kongpracha+P%22">Kongpracha P</searchLink>; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, United States.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, United States.; Data Science and Biotechnology Institute, Gladstone Institutes, San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Bali+S%22">Bali S</searchLink>; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Montano+M%22">Montano M</searchLink>; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Rosecrans+J%22">Rosecrans J</searchLink>; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Matthay+M%22">Matthay M</searchLink>; Data Science and Biotechnology Institute, Gladstone Institutes, San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Togo+T%22">Togo T</searchLink>; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Gonciarz+RL%22">Gonciarz RL</searchLink>; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Gopalkrishnan+S%22">Gopalkrishnan S</searchLink>; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Neitz+RJ%22">Neitz RJ</searchLink>; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, United States.; Small Molecule Discovery Center, University of California San Francisco, San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Krogan+NJ%22">Krogan NJ</searchLink>; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, United States.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, United States.; Data Science and Biotechnology Institute, Gladstone Institutes, San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Swaney+DL%22">Swaney DL</searchLink>; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, United States.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, United States.; Data Science and Biotechnology Institute, Gladstone Institutes, San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Shoichet+BK%22">Shoichet BK</searchLink>; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Ott+M%22">Ott M</searchLink>; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, United States.; Department of Medicine, University of California San Francisco, San Francisco, United States.; Chan Zuckerberg Biohub- San Francisco, San Francisco, San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Renslo+AR%22">Renslo AR</searchLink>; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Ashworth+A%22">Ashworth A</searchLink>; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Fraser+JS%22">Fraser JS</searchLink>; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, United States. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101579614%22">ELife</searchLink> [Elife] 2025 Nov 19; Vol. 14. <i>Date of Electronic Publication: </i>2025 Nov 19. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22eLife+Sciences+Publications%2C+Ltd%22">eLife Sciences Publications, Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101579614 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2050-084X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%222050084X%22">2050084X </searchLink><i>NLM ISO Abbreviation: </i>Elife <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41258893 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.7554/eLife.103484 Languages: – Code: eng Text: English Titles: – TitleFull: The Mac1 ADP-ribosylhydrolase is a therapeutic target for SARS-CoV-2. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Suryawanshi RK – PersonEntity: Name: NameFull: Jaishankar P – PersonEntity: Name: NameFull: Correy GJ – PersonEntity: Name: NameFull: Rachman MM – PersonEntity: Name: NameFull: O'Leary PC – PersonEntity: Name: NameFull: Taha TY – PersonEntity: Name: NameFull: Matsui Y – PersonEntity: Name: NameFull: Zapatero-Belinchón FJ – PersonEntity: Name: NameFull: McCavitt-Malvido M – PersonEntity: Name: NameFull: Doruk YU – PersonEntity: Name: NameFull: Stevens MGV – PersonEntity: Name: NameFull: Diolaiti ME – PersonEntity: Name: NameFull: Jogalekar MP – PersonEntity: Name: NameFull: Chen H – PersonEntity: Name: NameFull: Richards AL – PersonEntity: Name: NameFull: Kongpracha P – PersonEntity: Name: NameFull: Bali S – PersonEntity: Name: NameFull: Montano M – PersonEntity: Name: NameFull: Rosecrans J – PersonEntity: Name: NameFull: Matthay M – PersonEntity: Name: NameFull: Togo T – PersonEntity: Name: NameFull: Gonciarz RL – PersonEntity: Name: NameFull: Gopalkrishnan S – PersonEntity: Name: NameFull: Neitz RJ – PersonEntity: Name: NameFull: Krogan NJ – PersonEntity: Name: NameFull: Swaney DL – PersonEntity: Name: NameFull: Shoichet BK – PersonEntity: Name: NameFull: Ott M – PersonEntity: Name: NameFull: Renslo AR – PersonEntity: Name: NameFull: Ashworth A – PersonEntity: Name: NameFull: Fraser JS IsPartOfRelationships: – BibEntity: Dates: – D: 19 M: 11 Text: 2025 Nov 19 Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 2050-084X Numbering: – Type: volume Value: 14 Titles: – TitleFull: ELife Type: main |
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