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Hydroxyurea induces an oxidative stress response that triggers ER expansion and cytoplasmic protein aggregation.

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Title: Hydroxyurea induces an oxidative stress response that triggers ER expansion and cytoplasmic protein aggregation.
Authors: Sánchez-Molina A; Centro Andaluz de Biología del Desarrollo, Departamento de Biología Molecular e Ingeniería Bioquímica, Universidad Pablo de Olavide, Seville, Spain., Bernal M; Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, Universidad de Málaga, Málaga, Spain.; Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina, IBIMA Plataforma BIONAND, Málaga, Spain.; CIBER de Enfermedades Raras (CIBERER), Madrid, Spain., Posligua-García JD; Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, Universidad de Málaga, Málaga, Spain.; Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina, IBIMA Plataforma BIONAND, Málaga, Spain., Pérez-Pulido AJ; Centro Andaluz de Biología del Desarrollo, Departamento de Biología Molecular e Ingeniería Bioquímica, Universidad Pablo de Olavide, Seville, Spain., de Cubas L; Oxidative Stress and Cell Cycle Group, Universitat Pompeu Fabra, Barcelona, Spain., Hidalgo E; Oxidative Stress and Cell Cycle Group, Universitat Pompeu Fabra, Barcelona, Spain., Valdivieso MH; Departamento de Microbiología y Genética, Universidad de Salamanca, Salamanca, Spain.; Instituto de Biología Funcional y Genómica, Consejo Superior de Investigaciones Científicas, Salamanca, Spain., Salas-Pino S; Centro Andaluz de Biología del Desarrollo, Departamento de Biología Molecular e Ingeniería Bioquímica, Universidad Pablo de Olavide, Seville, Spain., Daga RR; Centro Andaluz de Biología del Desarrollo, Departamento de Biología Molecular e Ingeniería Bioquímica, Universidad Pablo de Olavide, Seville, Spain.
Source: PLoS biology [PLoS Biol] 2025 Nov 19; Vol. 23 (11), pp. e3003493. Date of Electronic Publication: 2025 Nov 19 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet ISSN: 1545-7885 (Electronic) Linking ISSN: 15449173 NLM ISO Abbreviation: PLoS Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Hydroxyurea induces an oxidative stress response that triggers ER expansion and cytoplasmic protein aggregation.
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  Data: <searchLink fieldCode="AU" term="%22Sánchez-Molina+A%22">Sánchez-Molina A</searchLink>; Centro Andaluz de Biología del Desarrollo, Departamento de Biología Molecular e Ingeniería Bioquímica, Universidad Pablo de Olavide, Seville, Spain.<br /><searchLink fieldCode="AU" term="%22Bernal+M%22">Bernal M</searchLink>; Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, Universidad de Málaga, Málaga, Spain.; Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina, IBIMA Plataforma BIONAND, Málaga, Spain.; CIBER de Enfermedades Raras (CIBERER), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Posligua-García+JD%22">Posligua-García JD</searchLink>; Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, Universidad de Málaga, Málaga, Spain.; Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina, IBIMA Plataforma BIONAND, Málaga, Spain.<br /><searchLink fieldCode="AU" term="%22Pérez-Pulido+AJ%22">Pérez-Pulido AJ</searchLink>; Centro Andaluz de Biología del Desarrollo, Departamento de Biología Molecular e Ingeniería Bioquímica, Universidad Pablo de Olavide, Seville, Spain.<br /><searchLink fieldCode="AU" term="%22de+Cubas+L%22">de Cubas L</searchLink>; Oxidative Stress and Cell Cycle Group, Universitat Pompeu Fabra, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Hidalgo+E%22">Hidalgo E</searchLink>; Oxidative Stress and Cell Cycle Group, Universitat Pompeu Fabra, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Valdivieso+MH%22">Valdivieso MH</searchLink>; Departamento de Microbiología y Genética, Universidad de Salamanca, Salamanca, Spain.; Instituto de Biología Funcional y Genómica, Consejo Superior de Investigaciones Científicas, Salamanca, Spain.<br /><searchLink fieldCode="AU" term="%22Salas-Pino+S%22">Salas-Pino S</searchLink>; Centro Andaluz de Biología del Desarrollo, Departamento de Biología Molecular e Ingeniería Bioquímica, Universidad Pablo de Olavide, Seville, Spain.<br /><searchLink fieldCode="AU" term="%22Daga+RR%22">Daga RR</searchLink>; Centro Andaluz de Biología del Desarrollo, Departamento de Biología Molecular e Ingeniería Bioquímica, Universidad Pablo de Olavide, Seville, Spain.
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  Data: <searchLink fieldCode="JN" term="%22101183755%22">PLoS biology</searchLink> [PLoS Biol] 2025 Nov 19; Vol. 23 (11), pp. e3003493. <i>Date of Electronic Publication: </i>2025 Nov 19 (<i>Print Publication: </i>2025).
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              Text: 2025 Nov 19
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