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Differential ion selectivity and disease-associated dysfunction of TRPML channels revealed by patient and engineered mutants.

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Title: Differential ion selectivity and disease-associated dysfunction of TRPML channels revealed by patient and engineered mutants.
Authors: Rue BE; Department of Biological Sciences, University of Denver, Denver, Colorado, USA., Dischler AM; Department of Biological Sciences, University of Denver, Denver, Colorado, USA., Salvagio LA; Department of Biological Sciences, University of Denver, Denver, Colorado, USA., Zhu M; Cherry Creek High School, Greenwood Village, Colorado, USA., Xu G; Cherry Creek High School, Greenwood Village, Colorado, USA., Flores PC; Department of Biological Sciences, University of Denver, Denver, Colorado, USA., Donovan CL; Department of Biological Sciences, University of Denver, Denver, Colorado, USA., Liu X; Department of Biological Sciences, University of Denver, Denver, Colorado, USA., Minckley TF; Department of Biological Sciences, University of Denver, Denver, Colorado, USA., Agulnek B; Department of Biological Sciences, University of Denver, Denver, Colorado, USA., Qin Y; Department of Biological Sciences, University of Denver, Denver, Colorado, USA. Electronic address: Yan.Qin@du.edu.
Source: The Journal of biological chemistry [J Biol Chem] 2026 Jan; Vol. 302 (1), pp. 110953. Date of Electronic Publication: 2025 Nov 17.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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DbLabel: MEDLINE Ultimate
An: 41260338
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Differential ion selectivity and disease-associated dysfunction of TRPML channels revealed by patient and engineered mutants.
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  Data: <searchLink fieldCode="AU" term="%22Rue+BE%22">Rue BE</searchLink>; Department of Biological Sciences, University of Denver, Denver, Colorado, USA.<br /><searchLink fieldCode="AU" term="%22Dischler+AM%22">Dischler AM</searchLink>; Department of Biological Sciences, University of Denver, Denver, Colorado, USA.<br /><searchLink fieldCode="AU" term="%22Salvagio+LA%22">Salvagio LA</searchLink>; Department of Biological Sciences, University of Denver, Denver, Colorado, USA.<br /><searchLink fieldCode="AU" term="%22Zhu+M%22">Zhu M</searchLink>; Cherry Creek High School, Greenwood Village, Colorado, USA.<br /><searchLink fieldCode="AU" term="%22Xu+G%22">Xu G</searchLink>; Cherry Creek High School, Greenwood Village, Colorado, USA.<br /><searchLink fieldCode="AU" term="%22Flores+PC%22">Flores PC</searchLink>; Department of Biological Sciences, University of Denver, Denver, Colorado, USA.<br /><searchLink fieldCode="AU" term="%22Donovan+CL%22">Donovan CL</searchLink>; Department of Biological Sciences, University of Denver, Denver, Colorado, USA.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Department of Biological Sciences, University of Denver, Denver, Colorado, USA.<br /><searchLink fieldCode="AU" term="%22Minckley+TF%22">Minckley TF</searchLink>; Department of Biological Sciences, University of Denver, Denver, Colorado, USA.<br /><searchLink fieldCode="AU" term="%22Agulnek+B%22">Agulnek B</searchLink>; Department of Biological Sciences, University of Denver, Denver, Colorado, USA.<br /><searchLink fieldCode="AU" term="%22Qin+Y%22">Qin Y</searchLink>; Department of Biological Sciences, University of Denver, Denver, Colorado, USA. Electronic address: Yan.Qin@du.edu.
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  Data: <searchLink fieldCode="JN" term="%222985121R%22">The Journal of biological chemistry</searchLink> [J Biol Chem] 2026 Jan; Vol. 302 (1), pp. 110953. <i>Date of Electronic Publication: </i>2025 Nov 17.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Inc%2E+on+behalf+of+American+Society+for+Biochemistry+and+Molecular+Biology%22">Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>2985121R <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1083-351X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200219258%22">00219258 </searchLink><i>NLM ISO Abbreviation: </i>J Biol Chem <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.jbc.2025.110953
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        Text: English
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      – TitleFull: Differential ion selectivity and disease-associated dysfunction of TRPML channels revealed by patient and engineered mutants.
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              Text: 2026 Jan
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