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Epigenetic age predicts depressive symptoms during the COVID-19 pandemic in the Canadian Longitudinal Study on Aging: importance of biological sex.

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Title: Epigenetic age predicts depressive symptoms during the COVID-19 pandemic in the Canadian Longitudinal Study on Aging: importance of biological sex.
Authors: Barha CK; Barha Brain Health Laboratory, Faculty of Kinesiology, University of Calgary, Alberta, Canada.; Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.; Aging, Mobility, and Cognitive Neuroscience Laboratory, Department of Physical Therapy, University of British Columbia, Vancouver, BC, Canada.; Djavad Mowafaghian Centre for Brain Health, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada., Liu-Ambrose T; Aging, Mobility, and Cognitive Neuroscience Laboratory, Department of Physical Therapy, University of British Columbia, Vancouver, BC, Canada.; Djavad Mowafaghian Centre for Brain Health, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada., Inkster AM; Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.; BC Children’s Hospital Research Institute, Vancouver, BC, Canada., Falck RS; Aging, Mobility, and Cognitive Neuroscience Laboratory, Department of Physical Therapy, University of British Columbia, Vancouver, BC, Canada.; Djavad Mowafaghian Centre for Brain Health, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.; School of Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada., Burma JS; Barha Brain Health Laboratory, Faculty of Kinesiology, University of Calgary, Alberta, Canada.; Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada., Kirkland S; Department of Community Health and Epidemiology, Dalhousie University, Halifax, Nova Scotia, Canada., Griffith LE; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.; McMaster Institute for Research on Aging, McMaster University, Hamilton, ON, Canada., Thompson M; Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada., Basta NE; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada., McMillan JM; Division of Geriatric Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Balion C; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada., Wolfson C; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada., Raina P; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.; McMaster Institute for Research on Aging, McMaster University, Hamilton, ON, Canada.
Corporate Authors: Canadian Longitudinal Study on Aging (CLSA) Team
Source: Aging [Aging (Albany NY)] 2025 Nov 18; Vol. 17 (11), pp. 2759-2777. Date of Electronic Publication: 2025 Nov 18.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Impact Journals, LLC Country of Publication: United States NLM ID: 101508617 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1945-4589 (Electronic) Linking ISSN: 19454589 NLM ISO Abbreviation: Aging (Albany NY) Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Barha+CK%22">Barha CK</searchLink>; Barha Brain Health Laboratory, Faculty of Kinesiology, University of Calgary, Alberta, Canada.; Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.; Aging, Mobility, and Cognitive Neuroscience Laboratory, Department of Physical Therapy, University of British Columbia, Vancouver, BC, Canada.; Djavad Mowafaghian Centre for Brain Health, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Liu-Ambrose+T%22">Liu-Ambrose T</searchLink>; Aging, Mobility, and Cognitive Neuroscience Laboratory, Department of Physical Therapy, University of British Columbia, Vancouver, BC, Canada.; Djavad Mowafaghian Centre for Brain Health, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Inkster+AM%22">Inkster AM</searchLink>; Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.; BC Children’s Hospital Research Institute, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Falck+RS%22">Falck RS</searchLink>; Aging, Mobility, and Cognitive Neuroscience Laboratory, Department of Physical Therapy, University of British Columbia, Vancouver, BC, Canada.; Djavad Mowafaghian Centre for Brain Health, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.; School of Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Burma+JS%22">Burma JS</searchLink>; Barha Brain Health Laboratory, Faculty of Kinesiology, University of Calgary, Alberta, Canada.; Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Kirkland+S%22">Kirkland S</searchLink>; Department of Community Health and Epidemiology, Dalhousie University, Halifax, Nova Scotia, Canada.<br /><searchLink fieldCode="AU" term="%22Griffith+LE%22">Griffith LE</searchLink>; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.; McMaster Institute for Research on Aging, McMaster University, Hamilton, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Thompson+M%22">Thompson M</searchLink>; Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Basta+NE%22">Basta NE</searchLink>; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22McMillan+JM%22">McMillan JM</searchLink>; Division of Geriatric Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Balion+C%22">Balion C</searchLink>; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Wolfson+C%22">Wolfson C</searchLink>; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Raina+P%22">Raina P</searchLink>; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.; McMaster Institute for Research on Aging, McMaster University, Hamilton, ON, Canada.
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