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Hepatic zonation determines tumorigenic potential of mutant β-catenin.

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Title: Hepatic zonation determines tumorigenic potential of mutant β-catenin.
Authors: Raven A; Cancer Research UK Scotland Institute, Glasgow, UK., Gilroy K; Cancer Research UK Scotland Institute, Glasgow, UK., Jin H; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA., Waldron JA; Cancer Research UK Scotland Institute, Glasgow, UK., Leslie H; School of Cancer Sciences, University of Glasgow, Glasgow, UK., Munro J; Cancer Research UK Scotland Institute, Glasgow, UK., Hall H; Cancer Research UK Scotland Institute, Glasgow, UK., Ridgway RA; Cancer Research UK Scotland Institute, Glasgow, UK., Ford CA; Cancer Research UK Scotland Institute, Glasgow, UK., Gulhan DC; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA., Vlahov N; Cancer Research UK Scotland Institute, Glasgow, UK., Mills ML; Cancer Research UK Scotland Institute, Glasgow, UK., Hartley A; Cancer Research UK Scotland Institute, Glasgow, UK., Anderson E; Cancer Research UK Scotland Institute, Glasgow, UK., Bryson S; Cancer Research UK Scotland Institute, Glasgow, UK., Sphyris N; Cancer Research UK Scotland Institute, Glasgow, UK., Müller M; Cancer Research UK Scotland Institute, Glasgow, UK., May S; Cancer Research UK Scotland Institute, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Glasgow, UK., Cadden B; Cancer Research UK Scotland Institute, Glasgow, UK., Nixon C; Cancer Research UK Scotland Institute, Glasgow, UK., Waddell SH; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Guest R; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; CRUK Scotland Centre, Glasgow, UK., Boulter L; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; CRUK Scotland Centre, Glasgow, UK., Barker N; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Clevers H; Pharma, Research and Early Development (pRED) of F. Hoffmann-La Roche Ltd, Basel, Switzerland.; Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center, Utrecht, the Netherlands., Zhu H; Children's Research Institute and Children's Research Institute Mouse Genome Engineering Core, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA., Ivaska J; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland., Strathdee D; Cancer Research UK Scotland Institute, Glasgow, UK., Miller CJ; Cancer Research UK Scotland Institute, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Glasgow, UK.; CRUK Scotland Centre, Glasgow, UK., Jamieson NB; School of Cancer Sciences, University of Glasgow, Glasgow, UK.; CRUK Scotland Centre, Glasgow, UK., Bushell M; Cancer Research UK Scotland Institute, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Glasgow, UK., Park PJ; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA., Bird TG; Cancer Research UK Scotland Institute, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Glasgow, UK.; CRUK Scotland Centre, Glasgow, UK.; MRC Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK., Sansom OJ; Cancer Research UK Scotland Institute, Glasgow, UK. o.sansom@crukscotlandinstitute.ac.uk.; School of Cancer Sciences, University of Glasgow, Glasgow, UK. o.sansom@crukscotlandinstitute.ac.uk.; CRUK Scotland Centre, Glasgow, UK. o.sansom@crukscotlandinstitute.ac.uk.
Source: Nature [Nature] 2026 Jan; Vol. 649 (8097), pp. 739-748. Date of Electronic Publication: 2025 Nov 19.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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Hoffmann-La Roche Ltd, Basel, Switzerland.; Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Zhu+H%22">Zhu H</searchLink>; Children's Research Institute and Children's Research Institute Mouse Genome Engineering Core, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Ivaska+J%22">Ivaska J</searchLink>; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.<br /><searchLink fieldCode="AU" term="%22Strathdee+D%22">Strathdee D</searchLink>; Cancer Research UK Scotland Institute, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Miller+CJ%22">Miller CJ</searchLink>; Cancer Research UK Scotland Institute, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Glasgow, UK.; CRUK Scotland Centre, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Jamieson+NB%22">Jamieson NB</searchLink>; School of Cancer Sciences, University of Glasgow, Glasgow, UK.; CRUK Scotland Centre, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Bushell+M%22">Bushell M</searchLink>; Cancer Research UK Scotland Institute, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Park+PJ%22">Park PJ</searchLink>; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Bird+TG%22">Bird TG</searchLink>; Cancer Research UK Scotland Institute, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Glasgow, UK.; CRUK Scotland Centre, Glasgow, UK.; MRC Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Sansom+OJ%22">Sansom OJ</searchLink>; Cancer Research UK Scotland Institute, Glasgow, UK. o.sansom@crukscotlandinstitute.ac.uk.; School of Cancer Sciences, University of Glasgow, Glasgow, UK. o.sansom@crukscotlandinstitute.ac.uk.; CRUK Scotland Centre, Glasgow, UK. o.sansom@crukscotlandinstitute.ac.uk.
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