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Lacosamide is Associated with a Higher Treatment Persistence at 12 Months than Brivaracetam and Perampanel Despite Similar Efficacy.

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Title: Lacosamide is Associated with a Higher Treatment Persistence at 12 Months than Brivaracetam and Perampanel Despite Similar Efficacy.
Authors: Roberti R; CRUISE Research Center, Science of Health Department, Magna Graecia University of Catanzaro, Viale Europa, 88100, Catanzaro, Italy., Politi C; CRUISE Research Center, Science of Health Department, Magna Graecia University of Catanzaro, Viale Europa, 88100, Catanzaro, Italy.; Institute of Clinical Physiology-National Research Council of Italy (IFC-CNR), Reggio Calabria, Italy., Anzellotti F; Department of Neurology, Epilepsy Center, 'SS Annunziata' Hospital, Chieti, Italy., Belcastro V; Neurology Unit, Maggiore Hospital, Azienda Socio Sanitaria Territoriale (ASST) Lodi, Lodi, Italy., Beretta S; Department of Neurology, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy., Boero G; Complex Structure of Neurology, SS Annunziata Hospital, Taranto, Italy., Bonanni P; Epilepsy and Clinical Neurophysiology Unit, IRCCS Eugenio Medea Scientific Institute, Conegliano, Treviso, Italy., Canafoglia L; Integrated Diagnostics for Epilepsy, Fondazione IRCCS Istituto Neurologico Besta-European Reference Network (ERN) EpiCARE, Milan, Italy., D'Aniello A; IRCCS NEUROMED, Pozzilli, IS, Italy., Dainese F; Clinical Neurophysiology Unit, Clinical Neurology, DIDAS Department, Padua, Italy., De Caro C; CRUISE Research Center, Science of Health Department, Magna Graecia University of Catanzaro, Viale Europa, 88100, Catanzaro, Italy.; Department of Pharmacy, University of Naples 'Federico II', Naples, Italy., Di Gennaro G; IRCCS NEUROMED, Pozzilli, IS, Italy., Di Giacomo R; Epilepsy Unit, Fondazione IRCCS Istituto Neurologico Besta-European Reference Network (ERN) EpiCARE, Milan, Italy., DiFrancesco JC; Department of Neurology, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy., Dono F; Department of Neurology, Epilepsy Center, 'SS Annunziata' Hospital, Chieti, Italy.; Department of Neuroscience, Imaging and Clinical Science, 'G. d'Annunzio' University of Chieti-Pescara, Chieti, Italy., Falcicchio G; DiBraiN Department, University of Bari 'Aldo Moro', Bari, Italy., Ferlazzo E; Department of Medical and Surgical Sciences, 'Magna Græcia' University of Catanzaro, Catanzaro, Italy.; Regional Epilepsy Centre, 'Bianchi-Melacrino-Morelli' Great Metropolitan Hospital, Reggio Calabria, Italy., Foschi N; Neurological Clinic, Department of Experimental and Clinical Medicine, Marche Polytechnic University, Ancona, Italy., Gambardella A; Institute of Neurology, Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy., Giordano A; Department of Advanced Medical and Surgical Sciences, University of Campania 'Luigi Vanvitelli', Naples, Italy., Labate A; Neurophysiopatology and Movement Disorders Clinic, University of Messina, Messina, Italy., La Neve A; DiBraiN Department, University of Bari 'Aldo Moro', Bari, Italy., Lattanzi S; Neurological Clinic, Department of Experimental and Clinical Medicine, Marche Polytechnic University, Ancona, Italy., Leggio U; Unit of Neurophysiopathology, Azienda Socio Sanitaria Territoriale (ASST) Spedali Civili, Brescia, Italy., Liguori C; Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.; Neurology Unit, University Hospital of Rome Tor Vergata, Rome, Italy., Maschio M; Center for Tumor-Related Epilepsy, UOSD Neurooncology, IRCCS Regina Elena National Cancer Institute, Rome, Italy., Mattioli P; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), Clinical Neurology, University of Genoa, Genoa, Italy.; Division of Clinical Neurophysiology and Epilepsy Center, IRCCS Ospedale Policlinico San Martino, Genoa, Italy., Nilo A; Clinical Neurology Unit, Department of Medicine (DMED), University of Udine, Udine, Italy., Operto FF; CRUISE Research Center, Science of Health Department, Magna Graecia University of Catanzaro, Viale Europa, 88100, Catanzaro, Italy.; Institute of Neurology, Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy., Pascarella A; Department of Medical and Surgical Sciences, 'Magna Græcia' University of Catanzaro, Catanzaro, Italy.; Regional Epilepsy Centre, 'Bianchi-Melacrino-Morelli' Great Metropolitan Hospital, Reggio Calabria, Italy., Pauletto G; Neurology Unit, Department of Head, Neck and Neurosciences, Santa Maria Della Misericordia University Hospital, Udine, Italy., Pellegrino L; Clinical Neurophysiology Unit, Clinical Neurology, DIDAS Department, Padua, Italy., Renna R; Neurology and Stroke Unit, Department of Neurosciences, AORN San Pio, Benevento, Italy., Strigaro G; Epilepsy Center, Neurology Unit, Department of Translational Medicine, University of Piemonte Orientale, and Azienda Ospedaliero-Universitaria 'Maggiore della Carità', Novara, Italy., Russo E; CRUISE Research Center, Science of Health Department, Magna Graecia University of Catanzaro, Viale Europa, 88100, Catanzaro, Italy. erusso@unicz.it., Di Gennaro G; CRUISE Research Center, Science of Health Department, Magna Graecia University of Catanzaro, Viale Europa, 88100, Catanzaro, Italy.
Corporate Authors: COMPARE Study Group
Source: Neurology and therapy [Neurol Ther] 2026 Feb; Vol. 15 (1), pp. 213-235. Date of Electronic Publication: 2025 Nov 20.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: New Zealand NLM ID: 101637818 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2193-8253 (Print) Linking ISSN: 21936536 NLM ISO Abbreviation: Neurol Ther Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Lacosamide is Associated with a Higher Treatment Persistence at 12 Months than Brivaracetam and Perampanel Despite Similar Efficacy.
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  Data: <searchLink fieldCode="AU" term="%22Roberti+R%22">Roberti R</searchLink>; CRUISE Research Center, Science of Health Department, Magna Graecia University of Catanzaro, Viale Europa, 88100, Catanzaro, Italy.<br /><searchLink fieldCode="AU" term="%22Politi+C%22">Politi C</searchLink>; CRUISE Research Center, Science of Health Department, Magna Graecia University of Catanzaro, Viale Europa, 88100, Catanzaro, Italy.; Institute of Clinical Physiology-National Research Council of Italy (IFC-CNR), Reggio Calabria, Italy.<br /><searchLink fieldCode="AU" term="%22Anzellotti+F%22">Anzellotti F</searchLink>; Department of Neurology, Epilepsy Center, 'SS Annunziata' Hospital, Chieti, Italy.<br /><searchLink fieldCode="AU" term="%22Belcastro+V%22">Belcastro V</searchLink>; Neurology Unit, Maggiore Hospital, Azienda Socio Sanitaria Territoriale (ASST) Lodi, Lodi, Italy.<br /><searchLink fieldCode="AU" term="%22Beretta+S%22">Beretta S</searchLink>; Department of Neurology, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.<br /><searchLink fieldCode="AU" term="%22Boero+G%22">Boero G</searchLink>; Complex Structure of Neurology, SS Annunziata Hospital, Taranto, Italy.<br /><searchLink fieldCode="AU" term="%22Bonanni+P%22">Bonanni P</searchLink>; Epilepsy and Clinical Neurophysiology Unit, IRCCS Eugenio Medea Scientific Institute, Conegliano, Treviso, Italy.<br /><searchLink fieldCode="AU" term="%22Canafoglia+L%22">Canafoglia L</searchLink>; Integrated Diagnostics for Epilepsy, Fondazione IRCCS Istituto Neurologico Besta-European Reference Network (ERN) EpiCARE, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22D'Aniello+A%22">D'Aniello A</searchLink>; IRCCS NEUROMED, Pozzilli, IS, Italy.<br /><searchLink fieldCode="AU" term="%22Dainese+F%22">Dainese F</searchLink>; Clinical Neurophysiology Unit, Clinical Neurology, DIDAS Department, Padua, Italy.<br /><searchLink fieldCode="AU" term="%22De+Caro+C%22">De Caro C</searchLink>; CRUISE Research Center, Science of Health Department, Magna Graecia University of Catanzaro, Viale Europa, 88100, Catanzaro, Italy.; Department of Pharmacy, University of Naples 'Federico II', Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Di+Gennaro+G%22">Di Gennaro G</searchLink>; IRCCS NEUROMED, Pozzilli, IS, Italy.<br /><searchLink fieldCode="AU" term="%22Di+Giacomo+R%22">Di Giacomo R</searchLink>; Epilepsy Unit, Fondazione IRCCS Istituto Neurologico Besta-European Reference Network (ERN) EpiCARE, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22DiFrancesco+JC%22">DiFrancesco JC</searchLink>; Department of Neurology, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.<br /><searchLink fieldCode="AU" term="%22Dono+F%22">Dono F</searchLink>; Department of Neurology, Epilepsy Center, 'SS Annunziata' Hospital, Chieti, Italy.; Department of Neuroscience, Imaging and Clinical Science, 'G. d'Annunzio' University of Chieti-Pescara, Chieti, Italy.<br /><searchLink fieldCode="AU" term="%22Falcicchio+G%22">Falcicchio G</searchLink>; DiBraiN Department, University of Bari 'Aldo Moro', Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Ferlazzo+E%22">Ferlazzo E</searchLink>; Department of Medical and Surgical Sciences, 'Magna Græcia' University of Catanzaro, Catanzaro, Italy.; Regional Epilepsy Centre, 'Bianchi-Melacrino-Morelli' Great Metropolitan Hospital, Reggio Calabria, Italy.<br /><searchLink fieldCode="AU" term="%22Foschi+N%22">Foschi N</searchLink>; Neurological Clinic, Department of Experimental and Clinical Medicine, Marche Polytechnic University, Ancona, Italy.<br /><searchLink fieldCode="AU" term="%22Gambardella+A%22">Gambardella A</searchLink>; Institute of Neurology, Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy.<br /><searchLink fieldCode="AU" term="%22Giordano+A%22">Giordano A</searchLink>; Department of Advanced Medical and Surgical Sciences, University of Campania 'Luigi Vanvitelli', Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Labate+A%22">Labate A</searchLink>; Neurophysiopatology and Movement Disorders Clinic, University of Messina, Messina, Italy.<br /><searchLink fieldCode="AU" term="%22La+Neve+A%22">La Neve A</searchLink>; DiBraiN Department, University of Bari 'Aldo Moro', Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Lattanzi+S%22">Lattanzi S</searchLink>; Neurological Clinic, Department of Experimental and Clinical Medicine, Marche Polytechnic University, Ancona, Italy.<br /><searchLink fieldCode="AU" term="%22Leggio+U%22">Leggio U</searchLink>; Unit of Neurophysiopathology, Azienda Socio Sanitaria Territoriale (ASST) Spedali Civili, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Liguori+C%22">Liguori C</searchLink>; Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.; Neurology Unit, University Hospital of Rome Tor Vergata, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Maschio+M%22">Maschio M</searchLink>; Center for Tumor-Related Epilepsy, UOSD Neurooncology, IRCCS Regina Elena National Cancer Institute, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Mattioli+P%22">Mattioli P</searchLink>; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), Clinical Neurology, University of Genoa, Genoa, Italy.; Division of Clinical Neurophysiology and Epilepsy Center, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Nilo+A%22">Nilo A</searchLink>; Clinical Neurology Unit, Department of Medicine (DMED), University of Udine, Udine, Italy.<br /><searchLink fieldCode="AU" term="%22Operto+FF%22">Operto FF</searchLink>; CRUISE Research Center, Science of Health Department, Magna Graecia University of Catanzaro, Viale Europa, 88100, Catanzaro, Italy.; Institute of Neurology, Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy.<br /><searchLink fieldCode="AU" term="%22Pascarella+A%22">Pascarella A</searchLink>; Department of Medical and Surgical Sciences, 'Magna Græcia' University of Catanzaro, Catanzaro, Italy.; Regional Epilepsy Centre, 'Bianchi-Melacrino-Morelli' Great Metropolitan Hospital, Reggio Calabria, Italy.<br /><searchLink fieldCode="AU" term="%22Pauletto+G%22">Pauletto G</searchLink>; Neurology Unit, Department of Head, Neck and Neurosciences, Santa Maria Della Misericordia University Hospital, Udine, Italy.<br /><searchLink fieldCode="AU" term="%22Pellegrino+L%22">Pellegrino L</searchLink>; Clinical Neurophysiology Unit, Clinical Neurology, DIDAS Department, Padua, Italy.<br /><searchLink fieldCode="AU" term="%22Renna+R%22">Renna R</searchLink>; Neurology and Stroke Unit, Department of Neurosciences, AORN San Pio, Benevento, Italy.<br /><searchLink fieldCode="AU" term="%22Strigaro+G%22">Strigaro G</searchLink>; Epilepsy Center, Neurology Unit, Department of Translational Medicine, University of Piemonte Orientale, and Azienda Ospedaliero-Universitaria 'Maggiore della Carità', Novara, Italy.<br /><searchLink fieldCode="AU" term="%22Russo+E%22">Russo E</searchLink>; CRUISE Research Center, Science of Health Department, Magna Graecia University of Catanzaro, Viale Europa, 88100, Catanzaro, Italy. erusso@unicz.it.<br /><searchLink fieldCode="AU" term="%22Di+Gennaro+G%22">Di Gennaro G</searchLink>; CRUISE Research Center, Science of Health Department, Magna Graecia University of Catanzaro, Viale Europa, 88100, Catanzaro, Italy.
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