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Not all saliva samples are equal: The role of cellular heterogeneity in DNA methylation and epigenetic age analyses with biological and psychosocial factors.

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Title: Not all saliva samples are equal: The role of cellular heterogeneity in DNA methylation and epigenetic age analyses with biological and psychosocial factors.
Authors: Chan MH; Edwin S. H. Leong Centre for Healthy Aging, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada; Department of Medical Genetics, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada; British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada; Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, BC, Canada; Department of Human Development and Family Science, Purdue University, West Lafayette, IN, USA., Meijer M; Edwin S. H. Leong Centre for Healthy Aging, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada; Department of Medical Genetics, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada; British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada; Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, BC, Canada., Merrill SM; Department of Psychology, University of Massachusetts Lowell, Lowell, MA, USA., Fu MPY; Edwin S. H. Leong Centre for Healthy Aging, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada; Department of Medical Genetics, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada; British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada; Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, BC, Canada., Lin D; British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada; Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, BC, Canada., MacIsaac JL; Edwin S. H. Leong Centre for Healthy Aging, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada; Department of Medical Genetics, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada; British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada; Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, BC, Canada., Riis JL; Institute for Interdisciplinary Salivary Bioscience Research, University of California, Irvine, CA, USA; Department of Health and Kinesiology, University of Illinois Urbana Champaign, Urbana, IL, USA., Granger DA; Institute for Interdisciplinary Salivary Bioscience Research, University of California, Irvine, CA, USA; Johns Hopkins University, School of Medicine, Baltimore, MD, USA., Thomas EA; Institute for Interdisciplinary Salivary Bioscience Research, University of California, Irvine, CA, USA; Department of Neurobiology and Behavior, University of California, Irvine, CA, USA., Kobor MS; Edwin S. H. Leong Centre for Healthy Aging, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada; Department of Medical Genetics, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada; British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada; Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, BC, Canada. Electronic address: michael.kobor@ubc.ca.
Source: Psychoneuroendocrinology [Psychoneuroendocrinology] 2026 Feb; Vol. 184, pp. 107688. Date of Electronic Publication: 2025 Nov 17.
Publication Type: Journal Article
Journal Info: Publisher: Pergamon Press Country of Publication: England NLM ID: 7612148 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3360 (Electronic) Linking ISSN: 03064530 NLM ISO Abbreviation: Psychoneuroendocrinology Subsets: MEDLINE
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  Data: Not all saliva samples are equal: The role of cellular heterogeneity in DNA methylation and epigenetic age analyses with biological and psychosocial factors.
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  Data: <searchLink fieldCode="AU" term="%22Chan+MH%22">Chan MH</searchLink>; Edwin S. H. Leong Centre for Healthy Aging, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada; Department of Medical Genetics, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada; British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada; Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, BC, Canada; Department of Human Development and Family Science, Purdue University, West Lafayette, IN, USA.<br /><searchLink fieldCode="AU" term="%22Meijer+M%22">Meijer M</searchLink>; Edwin S. H. Leong Centre for Healthy Aging, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada; Department of Medical Genetics, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada; British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada; Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Merrill+SM%22">Merrill SM</searchLink>; Department of Psychology, University of Massachusetts Lowell, Lowell, MA, USA.<br /><searchLink fieldCode="AU" term="%22Fu+MPY%22">Fu MPY</searchLink>; Edwin S. H. Leong Centre for Healthy Aging, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada; Department of Medical Genetics, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada; British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada; Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Lin+D%22">Lin D</searchLink>; British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada; Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22MacIsaac+JL%22">MacIsaac JL</searchLink>; Edwin S. H. Leong Centre for Healthy Aging, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada; Department of Medical Genetics, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada; British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada; Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Riis+JL%22">Riis JL</searchLink>; Institute for Interdisciplinary Salivary Bioscience Research, University of California, Irvine, CA, USA; Department of Health and Kinesiology, University of Illinois Urbana Champaign, Urbana, IL, USA.<br /><searchLink fieldCode="AU" term="%22Granger+DA%22">Granger DA</searchLink>; Institute for Interdisciplinary Salivary Bioscience Research, University of California, Irvine, CA, USA; Johns Hopkins University, School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Thomas+EA%22">Thomas EA</searchLink>; Institute for Interdisciplinary Salivary Bioscience Research, University of California, Irvine, CA, USA; Department of Neurobiology and Behavior, University of California, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kobor+MS%22">Kobor MS</searchLink>; Edwin S. H. Leong Centre for Healthy Aging, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada; Department of Medical Genetics, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada; British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada; Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, BC, Canada. Electronic address: michael.kobor@ubc.ca.
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  Data: <searchLink fieldCode="JN" term="%227612148%22">Psychoneuroendocrinology</searchLink> [Psychoneuroendocrinology] 2026 Feb; Vol. 184, pp. 107688. <i>Date of Electronic Publication: </i>2025 Nov 17.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Pergamon+Press%22">Pergamon Press </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>7612148 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1873-3360 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203064530%22">03064530 </searchLink><i>NLM ISO Abbreviation: </i>Psychoneuroendocrinology <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.psyneuen.2025.107688
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        Text: English
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              Text: 2026 Feb
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