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Inhibition of heme biosynthesis triggers cuproptosis in acute myeloid leukemia.

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Title: Inhibition of heme biosynthesis triggers cuproptosis in acute myeloid leukemia.
Authors: Lewis AC; Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC 3010, Australia., Gruber E; Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC 3010, Australia., Franich R; Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia., Armstrong J; Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia., Kelly MJ; Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC 3010, Australia., Opazo CM; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC 3010, Australia., Low YC; Murdoch Children's Research Institute, Melbourne, VIC 3052, Australia., Flippe L; Murdoch Children's Research Institute, Melbourne, VIC 3052, Australia; Department of Paediatrics, University of Melbourne, Melbourne, VIC 3010, Australia; The Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Murdoch Children's Research Institute, Parkville, VIC 3052, Australia., Wijanarko K; Murdoch Children's Research Institute, Melbourne, VIC 3052, Australia; The Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Murdoch Children's Research Institute, Parkville, VIC 3052, Australia., Rowe CL; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia., Mawal CH; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC 3010, Australia., Birrell A; Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC 3010, Australia., So J; Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC 3010, Australia., Vaidyanathan S; Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC 3010, Australia., Ting K; Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC 3010, Australia., Semcesen LN; Department of Biochemistry and Pharmacology, University of Melbourne, Melbourne, VIC 3010, Australia., Last K; Department of Biochemistry and Pharmacology, University of Melbourne, Melbourne, VIC 3010, Australia., Ang CS; Bio21 Institute, University of Melbourne, Parkville, VIC 3052, Australia., Pomilio G; Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia., Brown FC; Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia., Wei AH; Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia; Royal Melbourne Hospital, Melbourne, VIC 3052, Australia., Powell JA; Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, SA 5000, Australia; Adelaide Medical School, Faculty of Health Sciences, University of Adelaide, Adelaide, SA 5000, Australia., Ng ES; Murdoch Children's Research Institute, Melbourne, VIC 3052, Australia; Department of Paediatrics, University of Melbourne, Melbourne, VIC 3010, Australia; The Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Murdoch Children's Research Institute, Parkville, VIC 3052, Australia., Frazier AE; Murdoch Children's Research Institute, Melbourne, VIC 3052, Australia; Department of Paediatrics, University of Melbourne, Melbourne, VIC 3010, Australia., McArthur K; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia., Lalaoui N; Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia., Stroud DA; Murdoch Children's Research Institute, Melbourne, VIC 3052, Australia; Department of Biochemistry and Pharmacology, University of Melbourne, Melbourne, VIC 3010, Australia; Victorian Clinical Genetics Services, Murdoch Children's Research Institute, Melbourne, VIC 3052, Australia., Brown KK; Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC 3010, Australia; Department of Biochemistry and Pharmacology, University of Melbourne, Melbourne, VIC 3010, Australia., Johnstone RW; Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC 3010, Australia., Kats LM; Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC 3010, Australia; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia. Electronic address: lev.kats@petermac.org.
Source: Cell [Cell] 2026 Jan 08; Vol. 189 (1), pp. 215-232.e24. Date of Electronic Publication: 2025 Nov 19.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE
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  Data: Inhibition of heme biosynthesis triggers cuproptosis in acute myeloid leukemia.
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  Data: <searchLink fieldCode="AU" term="%22Lewis+AC%22">Lewis AC</searchLink>; Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Gruber+E%22">Gruber E</searchLink>; Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Franich+R%22">Franich R</searchLink>; Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia.<br /><searchLink fieldCode="AU" term="%22Armstrong+J%22">Armstrong J</searchLink>; Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia.<br /><searchLink fieldCode="AU" term="%22Kelly+MJ%22">Kelly MJ</searchLink>; Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Opazo+CM%22">Opazo CM</searchLink>; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Low+YC%22">Low YC</searchLink>; Murdoch Children's Research Institute, Melbourne, VIC 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Flippe+L%22">Flippe L</searchLink>; Murdoch Children's Research Institute, Melbourne, VIC 3052, Australia; Department of Paediatrics, University of Melbourne, Melbourne, VIC 3010, Australia; The Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Murdoch Children's Research Institute, Parkville, VIC 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Wijanarko+K%22">Wijanarko K</searchLink>; Murdoch Children's Research Institute, Melbourne, VIC 3052, Australia; The Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Murdoch Children's Research Institute, Parkville, VIC 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Rowe+CL%22">Rowe CL</searchLink>; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.<br /><searchLink fieldCode="AU" term="%22Mawal+CH%22">Mawal CH</searchLink>; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Birrell+A%22">Birrell A</searchLink>; Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC 3010, Australia.<br /><searchLink fieldCode="AU" term="%22So+J%22">So J</searchLink>; Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Vaidyanathan+S%22">Vaidyanathan S</searchLink>; Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Ting+K%22">Ting K</searchLink>; Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Semcesen+LN%22">Semcesen LN</searchLink>; Department of Biochemistry and Pharmacology, University of Melbourne, Melbourne, VIC 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Last+K%22">Last K</searchLink>; Department of Biochemistry and Pharmacology, University of Melbourne, Melbourne, VIC 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Ang+CS%22">Ang CS</searchLink>; Bio21 Institute, University of Melbourne, Parkville, VIC 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Pomilio+G%22">Pomilio G</searchLink>; Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Brown+FC%22">Brown FC</searchLink>; Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Wei+AH%22">Wei AH</searchLink>; Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia; Royal Melbourne Hospital, Melbourne, VIC 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Powell+JA%22">Powell JA</searchLink>; Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, SA 5000, Australia; Adelaide Medical School, Faculty of Health Sciences, University of Adelaide, Adelaide, SA 5000, Australia.<br /><searchLink fieldCode="AU" term="%22Ng+ES%22">Ng ES</searchLink>; Murdoch Children's Research Institute, Melbourne, VIC 3052, Australia; Department of Paediatrics, University of Melbourne, Melbourne, VIC 3010, Australia; The Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Murdoch Children's Research Institute, Parkville, VIC 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Frazier+AE%22">Frazier AE</searchLink>; Murdoch Children's Research Institute, Melbourne, VIC 3052, Australia; Department of Paediatrics, University of Melbourne, Melbourne, VIC 3010, Australia.<br /><searchLink fieldCode="AU" term="%22McArthur+K%22">McArthur K</searchLink>; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.<br /><searchLink fieldCode="AU" term="%22Lalaoui+N%22">Lalaoui N</searchLink>; Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Stroud+DA%22">Stroud DA</searchLink>; Murdoch Children's Research Institute, Melbourne, VIC 3052, Australia; Department of Biochemistry and Pharmacology, University of Melbourne, Melbourne, VIC 3010, Australia; Victorian Clinical Genetics Services, Murdoch Children's Research Institute, Melbourne, VIC 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Brown+KK%22">Brown KK</searchLink>; Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC 3010, Australia; Department of Biochemistry and Pharmacology, University of Melbourne, Melbourne, VIC 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Johnstone+RW%22">Johnstone RW</searchLink>; Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Kats+LM%22">Kats LM</searchLink>; Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC 3010, Australia; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia. Electronic address: lev.kats@petermac.org.
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  Data: <searchLink fieldCode="JN" term="%220413066%22">Cell</searchLink> [Cell] 2026 Jan 08; Vol. 189 (1), pp. 215-232.e24. <i>Date of Electronic Publication: </i>2025 Nov 19.
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