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Berberine rescues PANoptosis-Driven hemophagocytic lymphohistiocytosis via cardiolipin-mediated mitochondrial stabilization.

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Title: Berberine rescues PANoptosis-Driven hemophagocytic lymphohistiocytosis via cardiolipin-mediated mitochondrial stabilization.
Authors: Almars AI; Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, 21589, Saudi Arabia; Editome: Precision Gene Editing Research Group, King Fahad Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Alhasani RH; Department of Biology, Faculty of Science, Umm Al-Qura University, Makkah, Saudi Arabia., Alsharif I; Department of Biology, Jamoum University College, Umm Al-Qura University, 21955, Makkah, Saudi Arabia., Albalawi AE; Faculty of Science, Department of Biology, University of Tabuk, Tabuk, 47913, Saudi Arabia., Albalawi FE; College of Medicine, Fahad Bin Sultan University, Tabuk, 47721, Saudi Arabia., Alhashmi MH; Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, 21589, Saudi Arabia; Toxicology and Forensic Sciences Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, 22254, Saudi Arabia., Tounsi WA; Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, 21589, Saudi Arabia., Ghouth NM; Department of Biochemistry, Faculty of Medicine, Umm Al-Qura University, Makkah, 21955, Saudi Arabia., Aggad WS; Division of Anatomy, Department of Basic Medical Sciences, College of Medicine, University of Jeddah, Jeddah, 23890, Saudi Arabia., Mohammedsaleh ZM; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Saudi Arabia., Almohaimeed HM; Department of Basic Science, College of Medicine, Princess Nourah bint Abdulrahman, University, P.O.Box 84428, Riyadh, 11671, Saudi Arabia. Electronic address: hmalmohaimeed@pnu.edu.sa., Hasan T; Department of Basic Science, College of Medicine, Princess Nourah bint Abdulrahman, University, P.O.Box 84428, Riyadh, 11671, Saudi Arabia., Soliman MH; Department of Biology, College of Science in Yanbu, Taibah University, Madinah, Saudi Arabia; Botany and Microbiology Department, Faculty of Science, Cairo University, Giza, 12613, Egypt. Electronic address: hmona@sci.cu.edu.eg.
Source: European journal of pharmacology [Eur J Pharmacol] 2026 Jan 10; Vol. 1010, pp. 178384. Date of Electronic Publication: 2025 Nov 19.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Berberine rescues PANoptosis-Driven hemophagocytic lymphohistiocytosis via cardiolipin-mediated mitochondrial stabilization.
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  Data: <searchLink fieldCode="AU" term="%22Almars+AI%22">Almars AI</searchLink>; Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, 21589, Saudi Arabia; Editome: Precision Gene Editing Research Group, King Fahad Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Alhasani+RH%22">Alhasani RH</searchLink>; Department of Biology, Faculty of Science, Umm Al-Qura University, Makkah, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Alsharif+I%22">Alsharif I</searchLink>; Department of Biology, Jamoum University College, Umm Al-Qura University, 21955, Makkah, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Albalawi+AE%22">Albalawi AE</searchLink>; Faculty of Science, Department of Biology, University of Tabuk, Tabuk, 47913, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Albalawi+FE%22">Albalawi FE</searchLink>; College of Medicine, Fahad Bin Sultan University, Tabuk, 47721, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Alhashmi+MH%22">Alhashmi MH</searchLink>; Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, 21589, Saudi Arabia; Toxicology and Forensic Sciences Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, 22254, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Tounsi+WA%22">Tounsi WA</searchLink>; Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, 21589, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Ghouth+NM%22">Ghouth NM</searchLink>; Department of Biochemistry, Faculty of Medicine, Umm Al-Qura University, Makkah, 21955, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Aggad+WS%22">Aggad WS</searchLink>; Division of Anatomy, Department of Basic Medical Sciences, College of Medicine, University of Jeddah, Jeddah, 23890, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Mohammedsaleh+ZM%22">Mohammedsaleh ZM</searchLink>; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Almohaimeed+HM%22">Almohaimeed HM</searchLink>; Department of Basic Science, College of Medicine, Princess Nourah bint Abdulrahman, University, P.O.Box 84428, Riyadh, 11671, Saudi Arabia. Electronic address: hmalmohaimeed@pnu.edu.sa.<br /><searchLink fieldCode="AU" term="%22Hasan+T%22">Hasan T</searchLink>; Department of Basic Science, College of Medicine, Princess Nourah bint Abdulrahman, University, P.O.Box 84428, Riyadh, 11671, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Soliman+MH%22">Soliman MH</searchLink>; Department of Biology, College of Science in Yanbu, Taibah University, Madinah, Saudi Arabia; Botany and Microbiology Department, Faculty of Science, Cairo University, Giza, 12613, Egypt. Electronic address: hmona@sci.cu.edu.eg.
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  Data: <searchLink fieldCode="JN" term="%221254354%22">European journal of pharmacology</searchLink> [Eur J Pharmacol] 2026 Jan 10; Vol. 1010, pp. 178384. <i>Date of Electronic Publication: </i>2025 Nov 19.
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