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Sex-specific role of the 5-HT2A receptor in psilocybin-induced extinction of opioid reward.

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Title: Sex-specific role of the 5-HT2A receptor in psilocybin-induced extinction of opioid reward.
Authors: Jaster AM; Departments of Physiology and Biophysics, Virginia Commonwealth University, Richmond, VA, USA.; Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA., Hadlock TM; Department of Chemical Engineering, Virginia Tech, Blacksburg, VA, USA., Buzzi B; Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA., Maltman JL; Departments of Physiology and Biophysics, Virginia Commonwealth University, Richmond, VA, USA., Silva GM; Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA.; Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, VA, USA., Saha S; Departments of Physiology and Biophysics, Virginia Commonwealth University, Richmond, VA, USA., Koseli E; Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA., Pondelick AM; Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA., Thakur N; Departments of Physiology and Biophysics, Virginia Commonwealth University, Richmond, VA, USA., Zhang X; Department of Chemical Engineering, Virginia Tech, Blacksburg, VA, USA., Li G; Department of Chemical Engineering, Virginia Tech, Blacksburg, VA, USA., Ledesma-Corvi S; Departments of Physiology and Biophysics, Virginia Commonwealth University, Richmond, VA, USA., Moore KN; Departments of Physiology and Biophysics, Virginia Commonwealth University, Richmond, VA, USA., Peterson HR; Pharmaceutics, Virginia Commonwealth University, Richmond, VA, USA., Fujita B; Departments of Physiology and Biophysics, Virginia Commonwealth University, Richmond, VA, USA., Zylko AL; Departments of Physiology and Biophysics, Virginia Commonwealth University, Richmond, VA, USA., Lewis MR; Departments of Physiology and Biophysics, Virginia Commonwealth University, Richmond, VA, USA., Poklis JL; Pharmaceutics, Virginia Commonwealth University, Richmond, VA, USA., Halquist MS; Pharmaceutics, Virginia Commonwealth University, Richmond, VA, USA., Wolstenholme JT; Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA., Selley DE; Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA., Hamilton PJ; Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, VA, USA., Lu C; Department of Chemical Engineering, Virginia Tech, Blacksburg, VA, USA. changlu@vt.edu., Damaj MI; Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA. m.damaj@vcuhealth.org., González-Maeso J; Departments of Physiology and Biophysics, Virginia Commonwealth University, Richmond, VA, USA. javier.maeso@vcuhealth.org.; Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA. javier.maeso@vcuhealth.org.
Source: Nature communications [Nat Commun] 2025 Nov 20; Vol. 16 (1), pp. 10206. Date of Electronic Publication: 2025 Nov 20.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Sex-specific role of the 5-HT<subscript>2A</subscript> receptor in psilocybin-induced extinction of opioid reward.
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  Data: <searchLink fieldCode="AU" term="%22Jaster+AM%22">Jaster AM</searchLink>; Departments of Physiology and Biophysics, Virginia Commonwealth University, Richmond, VA, USA.; Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA.<br /><searchLink fieldCode="AU" term="%22Hadlock+TM%22">Hadlock TM</searchLink>; Department of Chemical Engineering, Virginia Tech, Blacksburg, VA, USA.<br /><searchLink fieldCode="AU" term="%22Buzzi+B%22">Buzzi B</searchLink>; Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA.<br /><searchLink fieldCode="AU" term="%22Maltman+JL%22">Maltman JL</searchLink>; Departments of Physiology and Biophysics, Virginia Commonwealth University, Richmond, VA, USA.<br /><searchLink fieldCode="AU" term="%22Silva+GM%22">Silva GM</searchLink>; Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA.; Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, VA, USA.<br /><searchLink fieldCode="AU" term="%22Saha+S%22">Saha S</searchLink>; Departments of Physiology and Biophysics, Virginia Commonwealth University, Richmond, VA, USA.<br /><searchLink fieldCode="AU" term="%22Koseli+E%22">Koseli E</searchLink>; Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA.<br /><searchLink fieldCode="AU" term="%22Pondelick+AM%22">Pondelick AM</searchLink>; Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA.<br /><searchLink fieldCode="AU" term="%22Thakur+N%22">Thakur N</searchLink>; Departments of Physiology and Biophysics, Virginia Commonwealth University, Richmond, VA, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; Department of Chemical Engineering, Virginia Tech, Blacksburg, VA, USA.<br /><searchLink fieldCode="AU" term="%22Li+G%22">Li G</searchLink>; Department of Chemical Engineering, Virginia Tech, Blacksburg, VA, USA.<br /><searchLink fieldCode="AU" term="%22Ledesma-Corvi+S%22">Ledesma-Corvi S</searchLink>; Departments of Physiology and Biophysics, Virginia Commonwealth University, Richmond, VA, USA.<br /><searchLink fieldCode="AU" term="%22Moore+KN%22">Moore KN</searchLink>; Departments of Physiology and Biophysics, Virginia Commonwealth University, Richmond, VA, USA.<br /><searchLink fieldCode="AU" term="%22Peterson+HR%22">Peterson HR</searchLink>; Pharmaceutics, Virginia Commonwealth University, Richmond, VA, USA.<br /><searchLink fieldCode="AU" term="%22Fujita+B%22">Fujita B</searchLink>; Departments of Physiology and Biophysics, Virginia Commonwealth University, Richmond, VA, USA.<br /><searchLink fieldCode="AU" term="%22Zylko+AL%22">Zylko AL</searchLink>; Departments of Physiology and Biophysics, Virginia Commonwealth University, Richmond, VA, USA.<br /><searchLink fieldCode="AU" term="%22Lewis+MR%22">Lewis MR</searchLink>; Departments of Physiology and Biophysics, Virginia Commonwealth University, Richmond, VA, USA.<br /><searchLink fieldCode="AU" term="%22Poklis+JL%22">Poklis JL</searchLink>; Pharmaceutics, Virginia Commonwealth University, Richmond, VA, USA.<br /><searchLink fieldCode="AU" term="%22Halquist+MS%22">Halquist MS</searchLink>; Pharmaceutics, Virginia Commonwealth University, Richmond, VA, USA.<br /><searchLink fieldCode="AU" term="%22Wolstenholme+JT%22">Wolstenholme JT</searchLink>; Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA.<br /><searchLink fieldCode="AU" term="%22Selley+DE%22">Selley DE</searchLink>; Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA.<br /><searchLink fieldCode="AU" term="%22Hamilton+PJ%22">Hamilton PJ</searchLink>; Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, VA, USA.<br /><searchLink fieldCode="AU" term="%22Lu+C%22">Lu C</searchLink>; Department of Chemical Engineering, Virginia Tech, Blacksburg, VA, USA. changlu@vt.edu.<br /><searchLink fieldCode="AU" term="%22Damaj+MI%22">Damaj MI</searchLink>; Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA. m.damaj@vcuhealth.org.<br /><searchLink fieldCode="AU" term="%22González-Maeso+J%22">González-Maeso J</searchLink>; Departments of Physiology and Biophysics, Virginia Commonwealth University, Richmond, VA, USA. javier.maeso@vcuhealth.org.; Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA. javier.maeso@vcuhealth.org.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2025 Nov 20; Vol. 16 (1), pp. 10206. <i>Date of Electronic Publication: </i>2025 Nov 20.
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