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An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice.

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Title: An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice.
Authors: Marques E; MRC Mitochondrial Biology Unit, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK., Burr SP; MRC Mitochondrial Biology Unit, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK., Casey AM; MRC Mitochondrial Biology Unit, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK., Stopforth RJ; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.; Division of Gastroenterology and Hepatology, Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., Yu CS; MRC Mitochondrial Biology Unit, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK., Turner K; MRC Mitochondrial Biology Unit, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK., Wolf DM; MRC Mitochondrial Biology Unit, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK., Dilucca M; Department of Medicine, Addenbrooke's hospital, Cambridge Biomedical Campus, Cambridge, UK., Paupe V; MRC Mitochondrial Biology Unit, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK., Chowdhury SR; MRC Mitochondrial Biology Unit, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK., Tyrrell VJ; Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK., Kramer R; MRC Mitochondrial Biology Unit, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK., Kanse YM; MRC Mitochondrial Biology Unit, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK., Pednekar C; Cancer Research UK Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Powell CA; MRC Mitochondrial Biology Unit, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK., Stewart JB; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Prudent J; MRC Mitochondrial Biology Unit, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK., Murphy MP; MRC Mitochondrial Biology Unit, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK., Minczuk M; MRC Mitochondrial Biology Unit, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.; Department of Clinical Neurosciences, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK., O'Donnell VB; Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK., Bryant CE; Department of Medicine, Addenbrooke's hospital, Cambridge Biomedical Campus, Cambridge, UK., Chinnery PF; MRC Mitochondrial Biology Unit, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.; Department of Clinical Neurosciences, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK., Kaser A; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.; Division of Gastroenterology and Hepatology, Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., von Kriegsheim A; Cancer Research UK Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Ryan DG; MRC Mitochondrial Biology Unit, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK. RYAND67@tcd.ie.; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College, Dublin 2, Ireland. RYAND67@tcd.ie.
Source: Nature communications [Nat Commun] 2025 Nov 20; Vol. 16 (1), pp. 10222. Date of Electronic Publication: 2025 Nov 20.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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MRC Mitochondrial Biology Unit, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK. RYAND67@tcd.ie.; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College, Dublin 2, Ireland. RYAND67@tcd.ie.
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