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Integrative focus on the space exposome-integrome: physiological challenges and practical limits of countermeasures beyond low Earth orbit.

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Title: Integrative focus on the space exposome-integrome: physiological challenges and practical limits of countermeasures beyond low Earth orbit.
Authors: Bailey DM; Neurovascular Research Laboratory, Faculty of Life Sciences and Education, University of South Wales, Glamorgan, UK. damian.bailey@southwales.ac.uk., Blottner D; Institute of Integrative Neuroanatomy, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.; Center of Space Medicine and Extreme Environments, Charité-Universitätsmedizin Berlin, Berlin, Germany., Gunga HC; Department of Physiology, Center of Space Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany., Schneider S; Institute of Movement and Neurosciences, Center for Health and Integrative Physiology in Space (CHIPS), German Sport University Cologne, Cologne, Germany., Wotring V; International Space University, Strasbourg, France.; Center for Space Medicine, Baylor College of Medicine, Houston, TX, USA., Baatout S; Institute of Nuclear Medical Applications, Belgian Nuclear Research Centre (SCK CEN), Mol, Belgium.; Gent University, Gent, Belgium., Durante M; Biophysics Department, GSI Helmholtzzentrum für Schwerionenforschung GmbH, Darmstadt, Germany.; Technische Universität Darmstadt, Institut für Physik Kondensierter Materie, Darmstadt, Germany.; Universita' Federico II, Dipartimento di Fisica 'Ettore Pancini', Naples, Italy., Olde Engberink RHG; Department of Internal Medicine, Section of Nephrology, Amsterdam UMC Location University of Amsterdam, Amsterdam, Netherlands.; Amsterdam Cardiovascular Sciences, Microcirculation, Amsterdam, Netherlands., Goswami N; Gravitational Physiology and Medicine Research Unit, Division of Physiology, Otto Löwi Research Center of Vascular Biology, Inflammation, and Immunity, Medical University of Graz, Graz, Austria.; College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates., Heer M; IU International University of Applied Sciences, Erfurt, Germany.; Institute of Nutritional and Food Sciences, University of Bonn, Bonn, Germany., Liphardt AM; Department of Internal Medicine 3 - Rheumatology & Immunology, Universitätsklinikum Erlangen & Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.; Deutsches Zentrum Immuntherapie (DZI), Universitätsklinikum Erlangen & Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Monici M; ASAcampus Joint Laboratory, ASA Res. Div., DSBSC-University of Florence, Florence, Italy., Pagnini F; Department of Psychology, Università Cattolica del Sacro Cuore, Milan, Italy., Stern C; German Aerospace Center, Institute of Aerospace Medicine, Cologne, Germany., Stukenborg JB; NORDFERTIL Research Lab Stockholm, Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, and Karolinska University Hospital, Solna, Sweden.; NORDFERTIL Research Lab Uppsala, Department of Organismal Biology, University of Uppsala, Uppsala, Sweden., Weber T; ESA, EAC European Astronaut Centre, Spaceship and Facilities Team, Cologne, Germany.; KBR GmbH, Cologne, Germany.; Aerospace Medicine & Rehabilitation Laboratory, Department of Sport, Exercise & Rehabilitation, Northumbria University, Newcastle upon Tyne, UK., Vico L; U1059, INSERM, University Jean Monnet, Mines Saint-Etienne, France., White O; Cognition action and sensorimotor plasticity (INSERM U1093 CAPS), Université Bourgogne Europe, UFR des Sciences du sport, Dijon, France., van Ombergen A; Directorate of Human and Robotic Exploration Programmes, European Space Agency, Cologne, Germany.; Translational Neurosciences, University of Antwerp, Antwerp, Belgium., Choukér A; Laboratory of Translational Research 'Stress and Immunity', Department of Anaesthesiology, LMU University Hospital, LMU Munich, Germany. alexander.chouker@med.uni-muenchen.de.
Source: NPJ microgravity [NPJ Microgravity] 2025 Nov 20; Vol. 11 (1), pp. 82. Date of Electronic Publication: 2025 Nov 20.
Publication Type: Journal Article; Review
Journal Info: Publisher: Springer Nature Country of Publication: United States NLM ID: 101703605 Publication Model: Electronic Cited Medium: Print ISSN: 2373-8065 (Print) Linking ISSN: 23738065 NLM ISO Abbreviation: NPJ Microgravity Subsets: PubMed not MEDLINE
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  Data: Integrative focus on the space exposome-integrome: physiological challenges and practical limits of countermeasures beyond low Earth orbit.
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  Data: <searchLink fieldCode="AU" term="%22Bailey+DM%22">Bailey DM</searchLink>; Neurovascular Research Laboratory, Faculty of Life Sciences and Education, University of South Wales, Glamorgan, UK. damian.bailey@southwales.ac.uk.<br /><searchLink fieldCode="AU" term="%22Blottner+D%22">Blottner D</searchLink>; Institute of Integrative Neuroanatomy, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.; Center of Space Medicine and Extreme Environments, Charité-Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Gunga+HC%22">Gunga HC</searchLink>; Department of Physiology, Center of Space Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Schneider+S%22">Schneider S</searchLink>; Institute of Movement and Neurosciences, Center for Health and Integrative Physiology in Space (CHIPS), German Sport University Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Wotring+V%22">Wotring V</searchLink>; International Space University, Strasbourg, France.; Center for Space Medicine, Baylor College of Medicine, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Baatout+S%22">Baatout S</searchLink>; Institute of Nuclear Medical Applications, Belgian Nuclear Research Centre (SCK CEN), Mol, Belgium.; Gent University, Gent, Belgium.<br /><searchLink fieldCode="AU" term="%22Durante+M%22">Durante M</searchLink>; Biophysics Department, GSI Helmholtzzentrum für Schwerionenforschung GmbH, Darmstadt, Germany.; Technische Universität Darmstadt, Institut für Physik Kondensierter Materie, Darmstadt, Germany.; Universita' Federico II, Dipartimento di Fisica 'Ettore Pancini', Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Olde+Engberink+RHG%22">Olde Engberink RHG</searchLink>; Department of Internal Medicine, Section of Nephrology, Amsterdam UMC Location University of Amsterdam, Amsterdam, Netherlands.; Amsterdam Cardiovascular Sciences, Microcirculation, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Goswami+N%22">Goswami N</searchLink>; Gravitational Physiology and Medicine Research Unit, Division of Physiology, Otto Löwi Research Center of Vascular Biology, Inflammation, and Immunity, Medical University of Graz, Graz, Austria.; College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates.<br /><searchLink fieldCode="AU" term="%22Heer+M%22">Heer M</searchLink>; IU International University of Applied Sciences, Erfurt, Germany.; Institute of Nutritional and Food Sciences, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Liphardt+AM%22">Liphardt AM</searchLink>; Department of Internal Medicine 3 - Rheumatology & Immunology, Universitätsklinikum Erlangen & Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.; Deutsches Zentrum Immuntherapie (DZI), Universitätsklinikum Erlangen & Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Monici+M%22">Monici M</searchLink>; ASAcampus Joint Laboratory, ASA Res. Div., DSBSC-University of Florence, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Pagnini+F%22">Pagnini F</searchLink>; Department of Psychology, Università Cattolica del Sacro Cuore, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Stern+C%22">Stern C</searchLink>; German Aerospace Center, Institute of Aerospace Medicine, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Stukenborg+JB%22">Stukenborg JB</searchLink>; NORDFERTIL Research Lab Stockholm, Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, and Karolinska University Hospital, Solna, Sweden.; NORDFERTIL Research Lab Uppsala, Department of Organismal Biology, University of Uppsala, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Weber+T%22">Weber T</searchLink>; ESA, EAC European Astronaut Centre, Spaceship and Facilities Team, Cologne, Germany.; KBR GmbH, Cologne, Germany.; Aerospace Medicine & Rehabilitation Laboratory, Department of Sport, Exercise & Rehabilitation, Northumbria University, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Vico+L%22">Vico L</searchLink>; U1059, INSERM, University Jean Monnet, Mines Saint-Etienne, France.<br /><searchLink fieldCode="AU" term="%22White+O%22">White O</searchLink>; Cognition action and sensorimotor plasticity (INSERM U1093 CAPS), Université Bourgogne Europe, UFR des Sciences du sport, Dijon, France.<br /><searchLink fieldCode="AU" term="%22van+Ombergen+A%22">van Ombergen A</searchLink>; Directorate of Human and Robotic Exploration Programmes, European Space Agency, Cologne, Germany.; Translational Neurosciences, University of Antwerp, Antwerp, Belgium.<br /><searchLink fieldCode="AU" term="%22Choukér+A%22">Choukér A</searchLink>; Laboratory of Translational Research 'Stress and Immunity', Department of Anaesthesiology, LMU University Hospital, LMU Munich, Germany. alexander.chouker@med.uni-muenchen.de.
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  Data: <searchLink fieldCode="JN" term="%22101703605%22">NPJ microgravity</searchLink> [NPJ Microgravity] 2025 Nov 20; Vol. 11 (1), pp. 82. <i>Date of Electronic Publication: </i>2025 Nov 20.
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