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FOXO1 links KRAS G12D and G12V alleles to glutamine and nitrogen metabolism in colorectal cancer.

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Title: FOXO1 links KRAS G12D and G12V alleles to glutamine and nitrogen metabolism in colorectal cancer.
Authors: Ber S; MRC Cancer Unit, University of Cambridge, Cambridge, CB2 0XZ, UK.; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK., Yang M; MRC Cancer Unit, University of Cambridge, Cambridge, CB2 0XZ, UK., Sciacovelli M; MRC Cancer Unit, University of Cambridge, Cambridge, CB2 0XZ, UK.; Department of Molecular and Clinical Cancer Medicine Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Samarajiwa S; MRC Cancer Unit, University of Cambridge, Cambridge, CB2 0XZ, UK., Patel K; MRC Cancer Unit, University of Cambridge, Cambridge, CB2 0XZ, UK., Nikitopoulou E; MRC Cancer Unit, University of Cambridge, Cambridge, CB2 0XZ, UK., Howitt A; MRC Cancer Unit, University of Cambridge, Cambridge, CB2 0XZ, UK., Cook SJ; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK., Venkitaraman AR; MRC Cancer Unit, University of Cambridge, Cambridge, CB2 0XZ, UK.; Cancer Science Institute of Singapore, Singapore, 117599, Singapore.; NUS Centre for Cancer Research (N2CR), National University of Singapore, Singapore, 117599, Singapore.; Institute of Molecular and Cell Biology (IMCB), A(∗)STAR, Singapore, 138673, Singapore.; Department of Oncology, University of Cambridge, Cambridge, CB2 0XZ, UK.; Department of Medicine, National University of Singapore, Singapore, 119228, Singapore., Frezza C; MRC Cancer Unit, University of Cambridge, Cambridge, CB2 0XZ, UK.; Institute for Metabolomics in Ageing, Cluster of Excellence Cellular Stress Responses in Aging-associated Diseases (CECAD), University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.; Institute of Genetics, Faculty of Mathematics and Natural Sciences, Faculty of Medicine, University of Cologne, Cologne, Germany., Esposito A; MRC Cancer Unit, University of Cambridge, Cambridge, CB2 0XZ, UK. alessandro.esposito@brunel.ac.uk.; Centre for Genome Engineering and Maintenance, College of Health, Medicine and Life Sciences, Brunel University London, London, UB8 3PH, UK. alessandro.esposito@brunel.ac.uk.
Source: EMBO reports [EMBO Rep] 2026 Jan; Vol. 27 (1), pp. 142-162. Date of Electronic Publication: 2025 Nov 20.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 100963049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-3178 (Electronic) Linking ISSN: 1469221X NLM ISO Abbreviation: EMBO Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: FOXO1 links KRAS G12D and G12V alleles to glutamine and nitrogen metabolism in colorectal cancer.
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  Data: <searchLink fieldCode="AU" term="%22Ber+S%22">Ber S</searchLink>; MRC Cancer Unit, University of Cambridge, Cambridge, CB2 0XZ, UK.; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK.<br /><searchLink fieldCode="AU" term="%22Yang+M%22">Yang M</searchLink>; MRC Cancer Unit, University of Cambridge, Cambridge, CB2 0XZ, UK.<br /><searchLink fieldCode="AU" term="%22Sciacovelli+M%22">Sciacovelli M</searchLink>; MRC Cancer Unit, University of Cambridge, Cambridge, CB2 0XZ, UK.; Department of Molecular and Clinical Cancer Medicine Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Samarajiwa+S%22">Samarajiwa S</searchLink>; MRC Cancer Unit, University of Cambridge, Cambridge, CB2 0XZ, UK.<br /><searchLink fieldCode="AU" term="%22Patel+K%22">Patel K</searchLink>; MRC Cancer Unit, University of Cambridge, Cambridge, CB2 0XZ, UK.<br /><searchLink fieldCode="AU" term="%22Nikitopoulou+E%22">Nikitopoulou E</searchLink>; MRC Cancer Unit, University of Cambridge, Cambridge, CB2 0XZ, UK.<br /><searchLink fieldCode="AU" term="%22Howitt+A%22">Howitt A</searchLink>; MRC Cancer Unit, University of Cambridge, Cambridge, CB2 0XZ, UK.<br /><searchLink fieldCode="AU" term="%22Cook+SJ%22">Cook SJ</searchLink>; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK.<br /><searchLink fieldCode="AU" term="%22Venkitaraman+AR%22">Venkitaraman AR</searchLink>; MRC Cancer Unit, University of Cambridge, Cambridge, CB2 0XZ, UK.; Cancer Science Institute of Singapore, Singapore, 117599, Singapore.; NUS Centre for Cancer Research (N2CR), National University of Singapore, Singapore, 117599, Singapore.; Institute of Molecular and Cell Biology (IMCB), A(∗)STAR, Singapore, 138673, Singapore.; Department of Oncology, University of Cambridge, Cambridge, CB2 0XZ, UK.; Department of Medicine, National University of Singapore, Singapore, 119228, Singapore.<br /><searchLink fieldCode="AU" term="%22Frezza+C%22">Frezza C</searchLink>; MRC Cancer Unit, University of Cambridge, Cambridge, CB2 0XZ, UK.; Institute for Metabolomics in Ageing, Cluster of Excellence Cellular Stress Responses in Aging-associated Diseases (CECAD), University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.; Institute of Genetics, Faculty of Mathematics and Natural Sciences, Faculty of Medicine, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Esposito+A%22">Esposito A</searchLink>; MRC Cancer Unit, University of Cambridge, Cambridge, CB2 0XZ, UK. alessandro.esposito@brunel.ac.uk.; Centre for Genome Engineering and Maintenance, College of Health, Medicine and Life Sciences, Brunel University London, London, UB8 3PH, UK. alessandro.esposito@brunel.ac.uk.
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              Text: 2026 Jan
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