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Tumour-based epigenetic signatures as markers of prostate cancer aggressiveness after radical prostatectomy.

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Title: Tumour-based epigenetic signatures as markers of prostate cancer aggressiveness after radical prostatectomy.
Authors: Zhu Y; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia.; Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Parkville, VIC, Australia., Zarean E; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia., Li DL; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia., O'Reilly RL; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia., Davis ID; Eastern Health Clinical School, Monash University, Box Hill, VIC, Australia.; Department of Oncology, Eastern Health, Box Hill, VIC, Australia., Taylor RA; Monash Biomedicine Discovery Institute, Department of Physiology, Monash University, Clayton, VIC, Australia.; Cancer Immunology Program, Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.; Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia., Azad AA; Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia., Bolton DM; Department of Urology, Austin Health, Melbourne, VIC, Australia.; Department of Surgery, University of Melbourne, Melbourne, VIC, Australia., Papa N; Department of Urology, Austin Health, Melbourne, VIC, Australia., Lawrentschuk N; EJ Whitten Prostate Cancer Research Centre, Epworth Healthcare, Melbourne, VIC, Australia.; Department of Urology, The Royal Melbourne Hospital, The University of Melbourne, Melbourne, VIC, Australia., MacInnis RJ; Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Parkville, VIC, Australia.; Cancer Epidemiology Division, Cancer Council Victoria, East Melbourne, VIC, Australia., Milne RL; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia.; Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Parkville, VIC, Australia.; Cancer Epidemiology Division, Cancer Council Victoria, East Melbourne, VIC, Australia., Giles GG; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia.; Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Parkville, VIC, Australia.; Cancer Epidemiology Division, Cancer Council Victoria, East Melbourne, VIC, Australia., Southey MC; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia.; Cancer Epidemiology Division, Cancer Council Victoria, East Melbourne, VIC, Australia.; Department of Clinical Pathology, Melbourne Medical School, The University of Melbourne, Melbourne, VIC, Australia., Dugué PA; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia. pierre-antoine.dugue@monash.edu.; Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Parkville, VIC, Australia. pierre-antoine.dugue@monash.edu.; Cancer Epidemiology Division, Cancer Council Victoria, East Melbourne, VIC, Australia. pierre-antoine.dugue@monash.edu.
Source: British journal of cancer [Br J Cancer] 2026 Feb; Vol. 134 (3), pp. 477-485. Date of Electronic Publication: 2025 Nov 20.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group on behalf of Cancer Research UK Country of Publication: England NLM ID: 0370635 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1827 (Electronic) Linking ISSN: 00070920 NLM ISO Abbreviation: Br J Cancer Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Zhu+Y%22">Zhu Y</searchLink>; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia.; Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Zarean+E%22">Zarean E</searchLink>; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Li+DL%22">Li DL</searchLink>; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22O'Reilly+RL%22">O'Reilly RL</searchLink>; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Davis+ID%22">Davis ID</searchLink>; Eastern Health Clinical School, Monash University, Box Hill, VIC, Australia.; Department of Oncology, Eastern Health, Box Hill, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Taylor+RA%22">Taylor RA</searchLink>; Monash Biomedicine Discovery Institute, Department of Physiology, Monash University, Clayton, VIC, Australia.; Cancer Immunology Program, Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.; Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Azad+AA%22">Azad AA</searchLink>; Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Bolton+DM%22">Bolton DM</searchLink>; Department of Urology, Austin Health, Melbourne, VIC, Australia.; Department of Surgery, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Papa+N%22">Papa N</searchLink>; Department of Urology, Austin Health, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Lawrentschuk+N%22">Lawrentschuk N</searchLink>; EJ Whitten Prostate Cancer Research Centre, Epworth Healthcare, Melbourne, VIC, Australia.; Department of Urology, The Royal Melbourne Hospital, The University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22MacInnis+RJ%22">MacInnis RJ</searchLink>; Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Parkville, VIC, Australia.; Cancer Epidemiology Division, Cancer Council Victoria, East Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Milne+RL%22">Milne RL</searchLink>; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia.; Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Parkville, VIC, Australia.; Cancer Epidemiology Division, Cancer Council Victoria, East Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Giles+GG%22">Giles GG</searchLink>; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia.; Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Parkville, VIC, Australia.; Cancer Epidemiology Division, Cancer Council Victoria, East Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Southey+MC%22">Southey MC</searchLink>; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia.; Cancer Epidemiology Division, Cancer Council Victoria, East Melbourne, VIC, Australia.; Department of Clinical Pathology, Melbourne Medical School, The University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Dugué+PA%22">Dugué PA</searchLink>; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia. pierre-antoine.dugue@monash.edu.; Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Parkville, VIC, Australia. pierre-antoine.dugue@monash.edu.; Cancer Epidemiology Division, Cancer Council Victoria, East Melbourne, VIC, Australia. pierre-antoine.dugue@monash.edu.
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