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Legumain-Cleavable Top1i Antibody-Drug Conjugates without Self-Immolative Spacers Demonstrate Potent Antitumor Activity.

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Title: Legumain-Cleavable Top1i Antibody-Drug Conjugates without Self-Immolative Spacers Demonstrate Potent Antitumor Activity.
Authors: Ojo VT; School of Pharmacy and Pharmaceutical Sciences, Binghamton University, PO Box 6000, Binghamton, New York 13902-6000, United States., Bianchi NA; School of Pharmacy and Pharmaceutical Sciences, Binghamton University, PO Box 6000, Binghamton, New York 13902-6000, United States., Yi MZ; School of Pharmacy and Pharmaceutical Sciences, Binghamton University, PO Box 6000, Binghamton, New York 13902-6000, United States., Chung SH; School of Pharmacy and Pharmaceutical Sciences, Binghamton University, PO Box 6000, Binghamton, New York 13902-6000, United States., Gray ME; School of Pharmacy and Pharmaceutical Sciences, Binghamton University, PO Box 6000, Binghamton, New York 13902-6000, United States., Rahman MA; School of Pharmacy and Pharmaceutical Sciences, Binghamton University, PO Box 6000, Binghamton, New York 13902-6000, United States., Elder KK; School of Pharmacy and Pharmaceutical Sciences, Binghamton University, PO Box 6000, Binghamton, New York 13902-6000, United States., Zhang T; School of Pharmacy and Pharmaceutical Sciences, Binghamton University, PO Box 6000, Binghamton, New York 13902-6000, United States., Brooks TA; School of Pharmacy and Pharmaceutical Sciences, Binghamton University, PO Box 6000, Binghamton, New York 13902-6000, United States., Tumey LN; School of Pharmacy and Pharmaceutical Sciences, Binghamton University, PO Box 6000, Binghamton, New York 13902-6000, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2025 Dec 11; Vol. 68 (23), pp. 25505-25522. Date of Electronic Publication: 2025 Nov 20.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Ojo+VT%22">Ojo VT</searchLink>; School of Pharmacy and Pharmaceutical Sciences, Binghamton University, PO Box 6000, Binghamton, New York 13902-6000, United States.<br /><searchLink fieldCode="AU" term="%22Bianchi+NA%22">Bianchi NA</searchLink>; School of Pharmacy and Pharmaceutical Sciences, Binghamton University, PO Box 6000, Binghamton, New York 13902-6000, United States.<br /><searchLink fieldCode="AU" term="%22Yi+MZ%22">Yi MZ</searchLink>; School of Pharmacy and Pharmaceutical Sciences, Binghamton University, PO Box 6000, Binghamton, New York 13902-6000, United States.<br /><searchLink fieldCode="AU" term="%22Chung+SH%22">Chung SH</searchLink>; School of Pharmacy and Pharmaceutical Sciences, Binghamton University, PO Box 6000, Binghamton, New York 13902-6000, United States.<br /><searchLink fieldCode="AU" term="%22Gray+ME%22">Gray ME</searchLink>; School of Pharmacy and Pharmaceutical Sciences, Binghamton University, PO Box 6000, Binghamton, New York 13902-6000, United States.<br /><searchLink fieldCode="AU" term="%22Rahman+MA%22">Rahman MA</searchLink>; School of Pharmacy and Pharmaceutical Sciences, Binghamton University, PO Box 6000, Binghamton, New York 13902-6000, United States.<br /><searchLink fieldCode="AU" term="%22Elder+KK%22">Elder KK</searchLink>; School of Pharmacy and Pharmaceutical Sciences, Binghamton University, PO Box 6000, Binghamton, New York 13902-6000, United States.<br /><searchLink fieldCode="AU" term="%22Zhang+T%22">Zhang T</searchLink>; School of Pharmacy and Pharmaceutical Sciences, Binghamton University, PO Box 6000, Binghamton, New York 13902-6000, United States.<br /><searchLink fieldCode="AU" term="%22Brooks+TA%22">Brooks TA</searchLink>; School of Pharmacy and Pharmaceutical Sciences, Binghamton University, PO Box 6000, Binghamton, New York 13902-6000, United States.<br /><searchLink fieldCode="AU" term="%22Tumey+LN%22">Tumey LN</searchLink>; School of Pharmacy and Pharmaceutical Sciences, Binghamton University, PO Box 6000, Binghamton, New York 13902-6000, United States.
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        Value: 10.1021/acs.jmedchem.5c02681
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              Text: 2025 Dec 11
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