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Oxaliplatin resistance in pancreatic ductal adenocarcinoma is non‑significantly mediated by diminished drug uptake but is highly linked to a poor apoptotic response to the cytotoxic threat.

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Title: Oxaliplatin resistance in pancreatic ductal adenocarcinoma is non‑significantly mediated by diminished drug uptake but is highly linked to a poor apoptotic response to the cytotoxic threat.
Authors: Röttgen H; Internal Medicine IX‑Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University, Medical Faculty Heidelberg, Heidelberg University Hospital, D‑69120 Heidelberg, Germany., Theurer L; Department of Food Chemistry and Toxicology, Karlsruhe Institute of Technology, D‑76131 Karlsruhe, Germany., Peccerella T; Department of General, Visceral, and Transplantation Surgery, Heidelberg University, Medical Faculty Heidelberg, Heidelberg University Hospital, D‑69120 Heidelberg, Germany., Sandu K; Internal Medicine IX‑Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University, Medical Faculty Heidelberg, Heidelberg University Hospital, D‑69120 Heidelberg, Germany., Weiss J; Internal Medicine IX‑Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University, Medical Faculty Heidelberg, Heidelberg University Hospital, D‑69120 Heidelberg, Germany., Burhenne J; Internal Medicine IX‑Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University, Medical Faculty Heidelberg, Heidelberg University Hospital, D‑69120 Heidelberg, Germany., Neoptolemos JP; Department of General, Visceral, and Transplantation Surgery, Heidelberg University, Medical Faculty Heidelberg, Heidelberg University Hospital, D‑69120 Heidelberg, Germany., Köberle B; Department of Food Chemistry and Toxicology, Karlsruhe Institute of Technology, D‑76131 Karlsruhe, Germany., Theile D; Internal Medicine IX‑Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University, Medical Faculty Heidelberg, Heidelberg University Hospital, D‑69120 Heidelberg, Germany.
Source: Oncology reports [Oncol Rep] 2026 Jan; Vol. 55 (1). Date of Electronic Publication: 2025 Nov 21.
Publication Type: Journal Article
Journal Info: Publisher: D.A. Spandidos Country of Publication: Greece NLM ID: 9422756 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1791-2431 (Electronic) Linking ISSN: 1021335X NLM ISO Abbreviation: Oncol Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Oxaliplatin resistance in pancreatic ductal adenocarcinoma is non‑significantly mediated by diminished drug uptake but is highly linked to a poor apoptotic response to the cytotoxic threat.
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  Data: <searchLink fieldCode="AU" term="%22Röttgen+H%22">Röttgen H</searchLink>; Internal Medicine IX‑Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University, Medical Faculty Heidelberg, Heidelberg University Hospital, D‑69120 Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Theurer+L%22">Theurer L</searchLink>; Department of Food Chemistry and Toxicology, Karlsruhe Institute of Technology, D‑76131 Karlsruhe, Germany.<br /><searchLink fieldCode="AU" term="%22Peccerella+T%22">Peccerella T</searchLink>; Department of General, Visceral, and Transplantation Surgery, Heidelberg University, Medical Faculty Heidelberg, Heidelberg University Hospital, D‑69120 Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Sandu+K%22">Sandu K</searchLink>; Internal Medicine IX‑Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University, Medical Faculty Heidelberg, Heidelberg University Hospital, D‑69120 Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Weiss+J%22">Weiss J</searchLink>; Internal Medicine IX‑Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University, Medical Faculty Heidelberg, Heidelberg University Hospital, D‑69120 Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Burhenne+J%22">Burhenne J</searchLink>; Internal Medicine IX‑Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University, Medical Faculty Heidelberg, Heidelberg University Hospital, D‑69120 Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Neoptolemos+JP%22">Neoptolemos JP</searchLink>; Department of General, Visceral, and Transplantation Surgery, Heidelberg University, Medical Faculty Heidelberg, Heidelberg University Hospital, D‑69120 Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Köberle+B%22">Köberle B</searchLink>; Department of Food Chemistry and Toxicology, Karlsruhe Institute of Technology, D‑76131 Karlsruhe, Germany.<br /><searchLink fieldCode="AU" term="%22Theile+D%22">Theile D</searchLink>; Internal Medicine IX‑Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University, Medical Faculty Heidelberg, Heidelberg University Hospital, D‑69120 Heidelberg, Germany.
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  Data: <searchLink fieldCode="JN" term="%229422756%22">Oncology reports</searchLink> [Oncol Rep] 2026 Jan; Vol. 55 (1). <i>Date of Electronic Publication: </i>2025 Nov 21.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22D%2EA%2E+Spandidos%22">D.A. Spandidos </searchLink><i>Country of Publication: </i>Greece <i>NLM ID: </i>9422756 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1791-2431 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%221021335X%22">1021335X </searchLink><i>NLM ISO Abbreviation: </i>Oncol Rep <i>Subsets: </i>MEDLINE
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        Value: 10.3892/or.2025.9027
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        Text: English
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              Text: 2026 Jan
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