Oxaliplatin resistance in pancreatic ductal adenocarcinoma is non‑significantly mediated by diminished drug uptake but is highly linked to a poor apoptotic response to the cytotoxic threat.

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Title: Oxaliplatin resistance in pancreatic ductal adenocarcinoma is non‑significantly mediated by diminished drug uptake but is highly linked to a poor apoptotic response to the cytotoxic threat.
Authors: Röttgen H; Internal Medicine IX‑Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University, Medical Faculty Heidelberg, Heidelberg University Hospital, D‑69120 Heidelberg, Germany., Theurer L; Department of Food Chemistry and Toxicology, Karlsruhe Institute of Technology, D‑76131 Karlsruhe, Germany., Peccerella T; Department of General, Visceral, and Transplantation Surgery, Heidelberg University, Medical Faculty Heidelberg, Heidelberg University Hospital, D‑69120 Heidelberg, Germany., Sandu K; Internal Medicine IX‑Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University, Medical Faculty Heidelberg, Heidelberg University Hospital, D‑69120 Heidelberg, Germany., Weiss J; Internal Medicine IX‑Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University, Medical Faculty Heidelberg, Heidelberg University Hospital, D‑69120 Heidelberg, Germany., Burhenne J; Internal Medicine IX‑Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University, Medical Faculty Heidelberg, Heidelberg University Hospital, D‑69120 Heidelberg, Germany., Neoptolemos JP; Department of General, Visceral, and Transplantation Surgery, Heidelberg University, Medical Faculty Heidelberg, Heidelberg University Hospital, D‑69120 Heidelberg, Germany., Köberle B; Department of Food Chemistry and Toxicology, Karlsruhe Institute of Technology, D‑76131 Karlsruhe, Germany., Theile D; Internal Medicine IX‑Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University, Medical Faculty Heidelberg, Heidelberg University Hospital, D‑69120 Heidelberg, Germany.
Source: Oncology reports [Oncol Rep] 2026 Jan; Vol. 55 (1). Date of Electronic Publication: 2025 Nov 21.
Publication Type: Journal Article
Journal Info: Publisher: D.A. Spandidos Country of Publication: Greece NLM ID: 9422756 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1791-2431 (Electronic) Linking ISSN: 1021335X NLM ISO Abbreviation: Oncol Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1791-2431
DOI:10.3892/or.2025.9027