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Endothelial senescent-cell-specific clearance alleviates metabolic dysfunction in obese mice.

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Title: Endothelial senescent-cell-specific clearance alleviates metabolic dysfunction in obese mice.
Authors: Suda M; Center for Advanced Gerotherapeutics, Cedars-Sinai Medical Center, Pacific Design Center, 8687 Melrose Avenue, West Hollywood, CA 90048, USA; Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA; Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, 3-1-3 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address: masayoshi.suda@cshs.org., Chaib S; Center for Advanced Gerotherapeutics, Cedars-Sinai Medical Center, Pacific Design Center, 8687 Melrose Avenue, West Hollywood, CA 90048, USA; Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA., Langhi Prata LGP; Center for Advanced Gerotherapeutics, Cedars-Sinai Medical Center, Pacific Design Center, 8687 Melrose Avenue, West Hollywood, CA 90048, USA; Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA., Zhu Y; Department of Physiology and Biomedical Engineering, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA; Sam and Ann Barshop Institute for Longevity and Aging Studies, Department of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA., Tripathi U; Department of Physiology and Biomedical Engineering, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA., Paul KH; Department of Physiology and Biomedical Engineering, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA., Palmer AK; Division of Hospital Internal Medicine, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA., Pirtskhalava T; Center for Advanced Gerotherapeutics, Cedars-Sinai Medical Center, Pacific Design Center, 8687 Melrose Avenue, West Hollywood, CA 90048, USA; Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA., Kulshreshtha V; Mayo Clinic Graduate School of Biomedical Sciences, Rochester, MN 55905, USA., Inman CL; Department of Physiology and Biomedical Engineering, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA., Johnson KO; Department of Physiology and Biomedical Engineering, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA., Giorgadze N; Center for Advanced Gerotherapeutics, Cedars-Sinai Medical Center, Pacific Design Center, 8687 Melrose Avenue, West Hollywood, CA 90048, USA., Huang R; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA; Department of Cardiovascular Surgery, Mayo Clinic College of Medicine, 200 First St., S.W., Rochester, MN 55905, USA., Roos CM; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA; Department of Cardiovascular Surgery, Mayo Clinic College of Medicine, 200 First St., S.W., Rochester, MN 55905, USA., Leon-Sanchez LF; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA; Department of Cardiovascular Surgery, Mayo Clinic College of Medicine, 200 First St., S.W., Rochester, MN 55905, USA., Miller JD; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA; Department of Cardiovascular Surgery, Mayo Clinic College of Medicine, 200 First St., S.W., Rochester, MN 55905, USA., White T; Department of Physiology and Biomedical Engineering, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA., Laux L; Masonic Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, E, Nils Hasselmo Hall, 312 Church Street S.E., Minneapolis, MN 55455, USA., Niedernhofer LJ; Masonic Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, E, Nils Hasselmo Hall, 312 Church Street S.E., Minneapolis, MN 55455, USA., Robbins PD; Masonic Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, E, Nils Hasselmo Hall, 312 Church Street S.E., Minneapolis, MN 55455, USA., Espinoza S; Center for Advanced Gerotherapeutics, Cedars-Sinai Medical Center, Pacific Design Center, 8687 Melrose Avenue, West Hollywood, CA 90048, USA., Musi N; Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA., Khosla S; Department of Physiology and Biomedical Engineering, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA., Tullius SG; Division of Transplant Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, 45 Francis St., Boston, MA 02115, USA., Tchkonia T; Center for Advanced Gerotherapeutics, Cedars-Sinai Medical Center, Pacific Design Center, 8687 Melrose Avenue, West Hollywood, CA 90048, USA; Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA., Kirkland JL; Center for Advanced Gerotherapeutics, Cedars-Sinai Medical Center, Pacific Design Center, 8687 Melrose Avenue, West Hollywood, CA 90048, USA; Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA. Electronic address: james.kirkland@cshs.org.
Source: Cell metabolism [Cell Metab] 2025 Dec 02; Vol. 37 (12), pp. 2455-2465.e6. Date of Electronic Publication: 2025 Nov 20.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101233170 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1932-7420 (Electronic) Linking ISSN: 15504131 NLM ISO Abbreviation: Cell Metab Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Endothelial senescent-cell-specific clearance alleviates metabolic dysfunction in obese mice.
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  Data: <searchLink fieldCode="AU" term="%22Suda+M%22">Suda M</searchLink>; Center for Advanced Gerotherapeutics, Cedars-Sinai Medical Center, Pacific Design Center, 8687 Melrose Avenue, West Hollywood, CA 90048, USA; Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA; Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, 3-1-3 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address: masayoshi.suda@cshs.org.<br /><searchLink fieldCode="AU" term="%22Chaib+S%22">Chaib S</searchLink>; Center for Advanced Gerotherapeutics, Cedars-Sinai Medical Center, Pacific Design Center, 8687 Melrose Avenue, West Hollywood, CA 90048, USA; Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA.<br /><searchLink fieldCode="AU" term="%22Langhi+Prata+LGP%22">Langhi Prata LGP</searchLink>; Center for Advanced Gerotherapeutics, Cedars-Sinai Medical Center, Pacific Design Center, 8687 Melrose Avenue, West Hollywood, CA 90048, USA; Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA.<br /><searchLink fieldCode="AU" term="%22Zhu+Y%22">Zhu Y</searchLink>; Department of Physiology and Biomedical Engineering, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA; Sam and Ann Barshop Institute for Longevity and Aging Studies, Department of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.<br /><searchLink fieldCode="AU" term="%22Tripathi+U%22">Tripathi U</searchLink>; Department of Physiology and Biomedical Engineering, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Paul+KH%22">Paul KH</searchLink>; Department of Physiology and Biomedical Engineering, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Palmer+AK%22">Palmer AK</searchLink>; Division of Hospital Internal Medicine, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Pirtskhalava+T%22">Pirtskhalava T</searchLink>; Center for Advanced Gerotherapeutics, Cedars-Sinai Medical Center, Pacific Design Center, 8687 Melrose Avenue, West Hollywood, CA 90048, USA; Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA.<br /><searchLink fieldCode="AU" term="%22Kulshreshtha+V%22">Kulshreshtha V</searchLink>; Mayo Clinic Graduate School of Biomedical Sciences, Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Inman+CL%22">Inman CL</searchLink>; Department of Physiology and Biomedical Engineering, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Johnson+KO%22">Johnson KO</searchLink>; Department of Physiology and Biomedical Engineering, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Giorgadze+N%22">Giorgadze N</searchLink>; Center for Advanced Gerotherapeutics, Cedars-Sinai Medical Center, Pacific Design Center, 8687 Melrose Avenue, West Hollywood, CA 90048, USA.<br /><searchLink fieldCode="AU" term="%22Huang+R%22">Huang R</searchLink>; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA; Department of Cardiovascular Surgery, Mayo Clinic College of Medicine, 200 First St., S.W., Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Roos+CM%22">Roos CM</searchLink>; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA; Department of Cardiovascular Surgery, Mayo Clinic College of Medicine, 200 First St., S.W., Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Leon-Sanchez+LF%22">Leon-Sanchez LF</searchLink>; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA; Department of Cardiovascular Surgery, Mayo Clinic College of Medicine, 200 First St., S.W., Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Miller+JD%22">Miller JD</searchLink>; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA; Department of Cardiovascular Surgery, Mayo Clinic College of Medicine, 200 First St., S.W., Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22White+T%22">White T</searchLink>; Department of Physiology and Biomedical Engineering, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Laux+L%22">Laux L</searchLink>; Masonic Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, E, Nils Hasselmo Hall, 312 Church Street S.E., Minneapolis, MN 55455, USA.<br /><searchLink fieldCode="AU" term="%22Niedernhofer+LJ%22">Niedernhofer LJ</searchLink>; Masonic Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, E, Nils Hasselmo Hall, 312 Church Street S.E., Minneapolis, MN 55455, USA.<br /><searchLink fieldCode="AU" term="%22Robbins+PD%22">Robbins PD</searchLink>; Masonic Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, E, Nils Hasselmo Hall, 312 Church Street S.E., Minneapolis, MN 55455, USA.<br /><searchLink fieldCode="AU" term="%22Espinoza+S%22">Espinoza S</searchLink>; Center for Advanced Gerotherapeutics, Cedars-Sinai Medical Center, Pacific Design Center, 8687 Melrose Avenue, West Hollywood, CA 90048, USA.<br /><searchLink fieldCode="AU" term="%22Musi+N%22">Musi N</searchLink>; Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA.<br /><searchLink fieldCode="AU" term="%22Khosla+S%22">Khosla S</searchLink>; Department of Physiology and Biomedical Engineering, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Tullius+SG%22">Tullius SG</searchLink>; Division of Transplant Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, 45 Francis St., Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Tchkonia+T%22">Tchkonia T</searchLink>; Center for Advanced Gerotherapeutics, Cedars-Sinai Medical Center, Pacific Design Center, 8687 Melrose Avenue, West Hollywood, CA 90048, USA; Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA.<br /><searchLink fieldCode="AU" term="%22Kirkland+JL%22">Kirkland JL</searchLink>; Center for Advanced Gerotherapeutics, Cedars-Sinai Medical Center, Pacific Design Center, 8687 Melrose Avenue, West Hollywood, CA 90048, USA; Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA. Electronic address: james.kirkland@cshs.org.
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