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Topoisomerase IIb binding delineates localized mutational processes and driver mutations in cancer genomes.

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Title: Topoisomerase IIb binding delineates localized mutational processes and driver mutations in cancer genomes.
Authors: Uusküla-Reimand L; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada.; Computational Biology Program, Ontario Institute for Cancer Research, Toronto, ON, Canada., Lee CA; Computational Biology Program, Ontario Institute for Cancer Research, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., Oh RH; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Klein ZP; Computational Biology Program, Ontario Institute for Cancer Research, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Adler N; Computational Biology Program, Ontario Institute for Cancer Research, Toronto, ON, Canada., Akhtar Alvi S; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada., Langille E; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Pasini E; Ajmera Transplant Centre, University Health Network, Toronto, ON, Canada., Cheng KCL; Computational Biology Program, Ontario Institute for Cancer Research, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., Serafimova E; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada., Abd-Rabbo D; Computational Biology Program, Ontario Institute for Cancer Research, Toronto, ON, Canada., Hou H; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada., Tsai R; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada., Bhat M; Ajmera Transplant Centre, University Health Network, Toronto, ON, Canada.; Division of Gastroenterology & Hepatology, Department of Medicine, University of Toronto, Toronto, ON, Canada., Schramek D; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Wilson MD; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Reimand J; Computational Biology Program, Ontario Institute for Cancer Research, Toronto, ON, Canada. Juri.Reimand@utoronto.ca.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada. Juri.Reimand@utoronto.ca.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. Juri.Reimand@utoronto.ca.
Source: Nature communications [Nat Commun] 2025 Nov 21; Vol. 16 (1), pp. 10241. Date of Electronic Publication: 2025 Nov 21.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Uusküla-Reimand+L%22">Uusküla-Reimand L</searchLink>; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada.; Computational Biology Program, Ontario Institute for Cancer Research, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Lee+CA%22">Lee CA</searchLink>; Computational Biology Program, Ontario Institute for Cancer Research, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Oh+RH%22">Oh RH</searchLink>; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Klein+ZP%22">Klein ZP</searchLink>; Computational Biology Program, Ontario Institute for Cancer Research, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Adler+N%22">Adler N</searchLink>; Computational Biology Program, Ontario Institute for Cancer Research, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Akhtar+Alvi+S%22">Akhtar Alvi S</searchLink>; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Langille+E%22">Langille E</searchLink>; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Pasini+E%22">Pasini E</searchLink>; Ajmera Transplant Centre, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Cheng+KCL%22">Cheng KCL</searchLink>; Computational Biology Program, Ontario Institute for Cancer Research, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Serafimova+E%22">Serafimova E</searchLink>; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Abd-Rabbo+D%22">Abd-Rabbo D</searchLink>; Computational Biology Program, Ontario Institute for Cancer Research, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Hou+H%22">Hou H</searchLink>; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Tsai+R%22">Tsai R</searchLink>; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Bhat+M%22">Bhat M</searchLink>; Ajmera Transplant Centre, University Health Network, Toronto, ON, Canada.; Division of Gastroenterology & Hepatology, Department of Medicine, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Schramek+D%22">Schramek D</searchLink>; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Wilson+MD%22">Wilson MD</searchLink>; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Reimand+J%22">Reimand J</searchLink>; Computational Biology Program, Ontario Institute for Cancer Research, Toronto, ON, Canada. Juri.Reimand@utoronto.ca.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada. Juri.Reimand@utoronto.ca.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. Juri.Reimand@utoronto.ca.
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