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Remodeling of the immune microenvironment is linked to adverse outcome in pediatric T cell acute lymphoblastic leukemia.

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Title: Remodeling of the immune microenvironment is linked to adverse outcome in pediatric T cell acute lymphoblastic leukemia.
Authors: Wiggers CRM; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Cho EY; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Ozdemir M; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Bamgbose G; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Hegel J; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Frede J; Harvard Medical School, Boston, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Warlitz F; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Heavican-Foral TB; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Pop I; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Shraim R; Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Pölönen P; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA., Koch V; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Tran TH; Division of Pediatric Hematology-Oncology, Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire Sainte-Justine, Montreal, QC, Canada., Mullighan CG; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA., Teachey DT; Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Bledsoe JR; Department of Pathology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Pikman Y; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Department of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA., Harris MH; Department of Pathology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Place AE; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Department of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA., Silverman LB; Division of Pediatric Hematology, Oncology and Stem Cell Transplantation, Columbia University Irving Medical Center, New York, NY, USA., Lohr JG; Harvard Medical School, Boston, MA, USA. jens.lohr@hci.utah.edu.; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA. jens.lohr@hci.utah.edu.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. jens.lohr@hci.utah.edu.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. jens.lohr@hci.utah.edu., Knoechel B; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. birgit.knoechel@hci.utah.edu.; Harvard Medical School, Boston, MA, USA. birgit.knoechel@hci.utah.edu.; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA. birgit.knoechel@hci.utah.edu.; Department of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA. birgit.knoechel@hci.utah.edu.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. birgit.knoechel@hci.utah.edu.
Source: Nature communications [Nat Commun] 2025 Nov 21; Vol. 16 (1), pp. 10263. Date of Electronic Publication: 2025 Nov 21.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Remodeling of the immune microenvironment is linked to adverse outcome in pediatric T cell acute lymphoblastic leukemia.
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  Data: <searchLink fieldCode="AU" term="%22Wiggers+CRM%22">Wiggers CRM</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Cho+EY%22">Cho EY</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ozdemir+M%22">Ozdemir M</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Bamgbose+G%22">Bamgbose G</searchLink>; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Hegel+J%22">Hegel J</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Frede+J%22">Frede J</searchLink>; Harvard Medical School, Boston, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Warlitz+F%22">Warlitz F</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Heavican-Foral+TB%22">Heavican-Foral TB</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Pop+I%22">Pop I</searchLink>; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Shraim+R%22">Shraim R</searchLink>; Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Pölönen+P%22">Pölönen P</searchLink>; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Koch+V%22">Koch V</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Tran+TH%22">Tran TH</searchLink>; Division of Pediatric Hematology-Oncology, Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire Sainte-Justine, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Mullighan+CG%22">Mullighan CG</searchLink>; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Teachey+DT%22">Teachey DT</searchLink>; Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Bledsoe+JR%22">Bledsoe JR</searchLink>; Department of Pathology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Pikman+Y%22">Pikman Y</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Department of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Harris+MH%22">Harris MH</searchLink>; Department of Pathology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Place+AE%22">Place AE</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Department of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Silverman+LB%22">Silverman LB</searchLink>; Division of Pediatric Hematology, Oncology and Stem Cell Transplantation, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Lohr+JG%22">Lohr JG</searchLink>; Harvard Medical School, Boston, MA, USA. jens.lohr@hci.utah.edu.; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA. jens.lohr@hci.utah.edu.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. jens.lohr@hci.utah.edu.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. jens.lohr@hci.utah.edu.<br /><searchLink fieldCode="AU" term="%22Knoechel+B%22">Knoechel B</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. birgit.knoechel@hci.utah.edu.; Harvard Medical School, Boston, MA, USA. birgit.knoechel@hci.utah.edu.; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA. birgit.knoechel@hci.utah.edu.; Department of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA. birgit.knoechel@hci.utah.edu.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. birgit.knoechel@hci.utah.edu.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2025 Nov 21; Vol. 16 (1), pp. 10263. <i>Date of Electronic Publication: </i>2025 Nov 21.
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