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Cross-dataset pan-cancer detection by correlating cell-free DNA fragment coverage with open chromatin sites across cell types.

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Title: Cross-dataset pan-cancer detection by correlating cell-free DNA fragment coverage with open chromatin sites across cell types.
Authors: Olsen LR; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Odinokov D; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Holsting JQ; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Kondrup K; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Iisager L; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Rusan M; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Clinical Pharmacology, Aarhus University Hospital, Aarhus, Denmark., Buus S; Department of Oncology, Aarhus University Hospital, Aarhus, Denmark., Laursen BE; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Oncology, Aarhus University Hospital, Aarhus, Denmark.; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Borre M; Department of Urology, Aarhus University Hospital, Aarhus, Denmark., Jochumsen MR; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Nuclear Medicine & PET-Centre, Aarhus University Hospital, Aarhus, Denmark.; Department of Nuclear Medicine, Gødstrup Hospital, Herning, Denmark., Bouchelouche K; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Nuclear Medicine & PET-Centre, Aarhus University Hospital, Aarhus, Denmark., Frydendahl A; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Rasmussen MH; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Henriksen TV; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Nesic M; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Demuth C; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Lindskrog SV; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Nordentoft I; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Lamy P; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Therkildsen C; Department of Surgical Gastroenterology, Copenhagen University Hospital-Amager Hvidovre, Hvidovre, Denmark., Dyrskjøt L; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Sørensen KD; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Andersen CL; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Jakobsen Skanderup A; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Besenbacher S; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark. besenbacher@clin.au.dk.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. besenbacher@clin.au.dk.; Bioinformatics Research Center, Aarhus University, Aarhus, Denmark. besenbacher@clin.au.dk.
Source: Nature communications [Nat Commun] 2025 Nov 21; Vol. 16 (1), pp. 11522. Date of Electronic Publication: 2025 Nov 21.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Cross-dataset pan-cancer detection by correlating cell-free DNA fragment coverage with open chromatin sites across cell types.
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  Data: <searchLink fieldCode="AU" term="%22Olsen+LR%22">Olsen LR</searchLink>; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Odinokov+D%22">Odinokov D</searchLink>; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Holsting+JQ%22">Holsting JQ</searchLink>; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Kondrup+K%22">Kondrup K</searchLink>; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Iisager+L%22">Iisager L</searchLink>; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Rusan+M%22">Rusan M</searchLink>; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Clinical Pharmacology, Aarhus University Hospital, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Buus+S%22">Buus S</searchLink>; Department of Oncology, Aarhus University Hospital, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Laursen+BE%22">Laursen BE</searchLink>; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Oncology, Aarhus University Hospital, Aarhus, Denmark.; Department of Biomedicine, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Borre+M%22">Borre M</searchLink>; Department of Urology, Aarhus University Hospital, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Jochumsen+MR%22">Jochumsen MR</searchLink>; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Nuclear Medicine & PET-Centre, Aarhus University Hospital, Aarhus, Denmark.; Department of Nuclear Medicine, Gødstrup Hospital, Herning, Denmark.<br /><searchLink fieldCode="AU" term="%22Bouchelouche+K%22">Bouchelouche K</searchLink>; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Nuclear Medicine & PET-Centre, Aarhus University Hospital, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Frydendahl+A%22">Frydendahl A</searchLink>; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Rasmussen+MH%22">Rasmussen MH</searchLink>; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Henriksen+TV%22">Henriksen TV</searchLink>; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Nesic+M%22">Nesic M</searchLink>; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Demuth+C%22">Demuth C</searchLink>; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Lindskrog+SV%22">Lindskrog SV</searchLink>; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Nordentoft+I%22">Nordentoft I</searchLink>; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Lamy+P%22">Lamy P</searchLink>; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Therkildsen+C%22">Therkildsen C</searchLink>; Department of Surgical Gastroenterology, Copenhagen University Hospital-Amager Hvidovre, Hvidovre, Denmark.<br /><searchLink fieldCode="AU" term="%22Dyrskjøt+L%22">Dyrskjøt L</searchLink>; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Sørensen+KD%22">Sørensen KD</searchLink>; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Andersen+CL%22">Andersen CL</searchLink>; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Jakobsen+Skanderup+A%22">Jakobsen Skanderup A</searchLink>; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Besenbacher+S%22">Besenbacher S</searchLink>; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark. besenbacher@clin.au.dk.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. besenbacher@clin.au.dk.; Bioinformatics Research Center, Aarhus University, Aarhus, Denmark. besenbacher@clin.au.dk.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2025 Nov 21; Vol. 16 (1), pp. 11522. <i>Date of Electronic Publication: </i>2025 Nov 21.
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