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Determinants of long-term response to patritumab deruxtecan in breast cancer patient-derived xenografts.

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Title: Determinants of long-term response to patritumab deruxtecan in breast cancer patient-derived xenografts.
Authors: Òdena A; Experimental Therapeutics Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.; Universitat de Barcelona (UB), Barcelona, Spain., Monserrat L; Experimental Therapeutics Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain., Brasó-Maristany F; Translational Genomics and Targeted Therapies in Solid Tumors, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.; Institute of Cancer and Blood Disease, Hospital Clinic of Barcelona, Barcelona, Spain.; Reveal Genomics, Barcelona, Spain., García-Galea E; Oncology Data Science Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain., Casals E; Universitat de Barcelona (UB), Barcelona, Spain.; Centro Nacional de Análisis Genómico (CNAG), Barcelona, Spain., Molina C; Experimental Therapeutics Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain., Herencia-Ropero A; Experimental Therapeutics Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain., Pedretti F; Experimental Therapeutics Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain., Domènech H; Experimental Therapeutics Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain., Guzmán M; Experimental Therapeutics Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain., Rodríguez O; Experimental Therapeutics Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain., Grueso J; Experimental Therapeutics Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain., Esteve-Codina A; Universitat de Barcelona (UB), Barcelona, Spain.; Centro Nacional de Análisis Genómico (CNAG), Barcelona, Spain., Dienstmann R; Oncology Data Science Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.; University of Vic - Central University of Catalonia, Vic, Spain., Chandarlapaty S; Departments of Pathology and Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Center for Molecular-Based Therapy, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Fan PD; Research and Development, Daiichi Sankyo, Inc, Basking Ridge, NJ, USA., Suto F; Research and Development, Daiichi Sankyo, Inc, Basking Ridge, NJ, USA., Oliveira M; Medical Oncology Department, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.; Breast Cancer Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain., Prat A; Translational Genomics and Targeted Therapies in Solid Tumors, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.; Institute of Cancer and Blood Disease, Hospital Clinic of Barcelona, Barcelona, Spain.; Reveal Genomics, Barcelona, Spain.; Department of Medicine, University of Barcelona, Barcelona, Spain.; Institute of Oncology (IOB) - Hospital Quirón Salud, Barcelona, Spain., Serra V; Experimental Therapeutics Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain. vserra@vhio.net.
Source: NPJ precision oncology [NPJ Precis Oncol] 2025 Nov 21; Vol. 9 (1), pp. 393. Date of Electronic Publication: 2025 Nov 21.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 101708166 Publication Model: Electronic Cited Medium: Print ISSN: 2397-768X (Print) Linking ISSN: 2397768X NLM ISO Abbreviation: NPJ Precis Oncol Subsets: PubMed not MEDLINE
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  Data: Determinants of long-term response to patritumab deruxtecan in breast cancer patient-derived xenografts.
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  Data: <searchLink fieldCode="AU" term="%22Òdena+A%22">Òdena A</searchLink>; Experimental Therapeutics Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.; Universitat de Barcelona (UB), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Monserrat+L%22">Monserrat L</searchLink>; Experimental Therapeutics Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Brasó-Maristany+F%22">Brasó-Maristany F</searchLink>; Translational Genomics and Targeted Therapies in Solid Tumors, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.; Institute of Cancer and Blood Disease, Hospital Clinic of Barcelona, Barcelona, Spain.; Reveal Genomics, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22García-Galea+E%22">García-Galea E</searchLink>; Oncology Data Science Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Casals+E%22">Casals E</searchLink>; Universitat de Barcelona (UB), Barcelona, Spain.; Centro Nacional de Análisis Genómico (CNAG), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Molina+C%22">Molina C</searchLink>; Experimental Therapeutics Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Herencia-Ropero+A%22">Herencia-Ropero A</searchLink>; Experimental Therapeutics Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Pedretti+F%22">Pedretti F</searchLink>; Experimental Therapeutics Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Domènech+H%22">Domènech H</searchLink>; Experimental Therapeutics Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Guzmán+M%22">Guzmán M</searchLink>; Experimental Therapeutics Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Rodríguez+O%22">Rodríguez O</searchLink>; Experimental Therapeutics Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Grueso+J%22">Grueso J</searchLink>; Experimental Therapeutics Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Esteve-Codina+A%22">Esteve-Codina A</searchLink>; Universitat de Barcelona (UB), Barcelona, Spain.; Centro Nacional de Análisis Genómico (CNAG), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Dienstmann+R%22">Dienstmann R</searchLink>; Oncology Data Science Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.; University of Vic - Central University of Catalonia, Vic, Spain.<br /><searchLink fieldCode="AU" term="%22Chandarlapaty+S%22">Chandarlapaty S</searchLink>; Departments of Pathology and Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Center for Molecular-Based Therapy, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Fan+PD%22">Fan PD</searchLink>; Research and Development, Daiichi Sankyo, Inc, Basking Ridge, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Suto+F%22">Suto F</searchLink>; Research and Development, Daiichi Sankyo, Inc, Basking Ridge, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Oliveira+M%22">Oliveira M</searchLink>; Medical Oncology Department, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.; Breast Cancer Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Prat+A%22">Prat A</searchLink>; Translational Genomics and Targeted Therapies in Solid Tumors, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.; Institute of Cancer and Blood Disease, Hospital Clinic of Barcelona, Barcelona, Spain.; Reveal Genomics, Barcelona, Spain.; Department of Medicine, University of Barcelona, Barcelona, Spain.; Institute of Oncology (IOB) - Hospital Quirón Salud, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Serra+V%22">Serra V</searchLink>; Experimental Therapeutics Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain. vserra@vhio.net.
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