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Efficacy and safety of efsubaglutide alfa in individuals with type 2 diabetes (SUPER1): a randomised, double-blind, placebo-controlled, Phase IIb/III trial.

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Title: Efficacy and safety of efsubaglutide alfa in individuals with type 2 diabetes (SUPER1): a randomised, double-blind, placebo-controlled, Phase IIb/III trial.
Authors: Zhu D; Department of Endocrinology, Nanjing Drum Tower Hospital, affiliated with Nanjing University School of Medicine, Nanjing, China. zhudalong@nju.edu.cn., Ma J; Department of Endocrinology, Nanjing First Hospital, Nanjing, China., Wang W; Department of Endocrinology, Nanjing Drum Tower Hospital, affiliated with Nanjing University School of Medicine, Nanjing, China., Shi B; Department of Endocrinology and Metabolism, the First Affiliated Hospital of Soochow University, Suzhou, China., Dong X; Department of Endocrinology and Metabolism, Jinan Central Hospital Affiliated to Shandong First Medical University, Jinan, China., Bian F; Department of Endocrinology and Metabolism, Cangzhou People's Hospital, Cangzhou, China., Li Q; Department of Endocrinology and Metabolism, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China., Wang Y; Department of Endocrinology and Metabolism, Nanyang First People's Hospital, Nanyang, China., Jiang C; Department of Endocrinology and Metabolism, First People's Hospital of Zunyi, Zunyi, China., Wang X; Department of Endocrinology and Metabolism, Central Hospital of Jinzhou, Jinzhou, China., Wang K; Department of Endocrinology and Metabolism, Nanjing Jiangning Hospital, Nanjing, China., Ling H; Department of Endocrinology and Metabolism, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, China., Shi X; Department of Endocrinology and Metabolism, the First Affiliated Hospital of Nanyang Medical College, Nanyang, China., Cheng Z; Department of Endocrinology and Metabolism, the Fourth Affiliated Hospital of Harbin Medical University, Harbin, China., Yuan G; Department of Endocrinology and Metabolism, Affiliated Hospital of Jiangsu University, Zhenjiang, China., Li L; Department of Endocrinology and Metabolism, the First Affiliated Hospital of Henan University of Science & Technology, Luoyang, China., Su X; Department of Endocrinology and Metabolism, Cangzhou Hospital of Integrated TCM-WM Hebei, Cangzhou, China., Lu Y; Department of Endocrinology and Metabolism, the Second Hospital of Nanjing Medical University, Nanjing, China., Song W; Department of Endocrinology and Metabolism, Chenzhou First People's Hospital, Chenzhou, China., Zhang Y; Department of Endocrinology and Metabolism, Pingxiang People's Hospital, Pingxiang, China., Hu W; Department of Endocrinology and Metabolism, Huai'an Second People's Hospital, Huai'an, China., Zhang X; Department of Endocrinology and Metabolism, Genertec Liaoyou Gem Flower Hospital, Panjin, China., Wang H; Department of Endocrinology and Metabolism, Handan First Hospital, Handan, China., Liu Y; Department of Endocrinology and Metabolism, Sir Run Run Hospital of Nanjing Medical University, Nanjing, China., Li J; Department of Endocrinology and Metabolism, Puyang Oilfield General Hospital, Puyang, China., Zhang L; Department of Endocrinology and Metabolism, Jincheng General Hospital, Jincheng, China., Liu Y; Department of Endocrinology and Metabolism, the Third People's Hospital of Datong, Datong, China., Sun X; Department of Endocrinology and Metabolism, Jilin Guowen Hospital, Changchun, China., Wang X; Department of Endocrinology and Metabolism, Yueyang Central Hospital, Yueyang, China., Zhang K; Department of Endocrinology and Metabolism, Tongji Hospital of Tongji University, Shanghai, China., Zhao Y; Department of Endocrinology and Metabolism, Cangzhou Central Hospital, Cangzhou, China., Zhang L; Department of Endocrinology and Metabolism, the Second Hospital of Shijiazhuang, Shijiazhuang, China., Pan T; Department of Endocrinology and Metabolism, the Second Hospital of Anhui Medical University, Hefei, China., Li P; Department of Endocrinology and Metabolism, Yuncheng Central Hospital, Yuncheng, China., Li S; Department of Endocrinology and Metabolism, Huizhou Central Hospital Huizhou, Huizhou, China., Zhou H; Department of Endocrinology and Metabolism, First People's Hospital of Changde, Changde, China., Jiang C; Department of Endocrinology and Metabolism, the Second People's Hospital of Yibin, Yibin, China., Zheng X; Department of Endocrinology and Metabolism, Beijing Boai Hospital, Beijing, China., Ni L; Department of Endocrinology and Metabolism, First People's Hospital of Huzhou, Huzhou, China., Feng B; Department of Endocrinology and Metabolism, Shanghai East Hospital, Shanghai, China., Li F; Department of Endocrinology and Metabolism, First People's Hospital of Jining, Jining, China., Piao L; Department of Endocrinology and Metabolism, Yanbian University Hospital, Yanji, China., Jin H; Department of Endocrinology and Metabolism, Meihekou Central Hospital, Meihekou, China., Liu Y; Department of Endocrinology and Metabolism, Daqing People's Hospital, Daqing, China., Cao H; Department of Endocrinology and Metabolism, Chengdu Fifth People's Hospital, Chengdu, China., Li Y; Department of Endocrinology and Metabolism, Beijing Pinggu Hospital, Beijing, China., Cai H; Department of Endocrinology and Metabolism, the Second Hospital of Jilin University, Changchun, China., Mao H; Department of Endocrinology and Metabolism, the Central Hospital of Wuhan, Wuhan, China., Liang Y; Department of Endocrinology and Metabolism, Shunde Hospital of Southern Medical University, Foshan, China., Guo J; Department of Endocrinology and Metabolism, the Second Hospital of Tianjin Medical University, Tianjin, China., Wang Y; Department of Endocrinology and Metabolism, the Affiliated Hospital of Qingdao University, Qingdao, China., Li Y; Department of Endocrinology and Metabolism, Chongqing University Three Gorges Hospital, Chongqing, China., Xu N; Department of Endocrinology and Metabolism, the First People's Hospital of Lianyungang, Lianyungang, China., Zhang J; Department of Endocrinology and Metabolism, Shanghai Pudong New District Zhoupu Hospital, Shanghai, China., Zhang Q; Department of Endocrinology and Metabolism, the First Affiliated Hospital of Anhui Medical University, Hefei, China., Pang W; Department of Endocrinology and Metabolism, Huaihe Hospital of Henan University, Kaifeng, China., Yu J; Department of Endocrinology and Metabolism, Jiujiang University Affiliated Hospital, Jiujiang, China., Xu Y; Division of Clinical Development, Innogen Pharmaceutical Co. Ltd, Shanghai, China., Zhou Y; Department of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China., Li Y; Department of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China., Wang Q; Division of Clinical Development, Innogen Pharmaceutical Co. Ltd, Shanghai, China. qh_wang@fudan.edu.cn.; Department of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China. qh_wang@fudan.edu.cn.
Source: Diabetologia [Diabetologia] 2026 Jun; Vol. 69 (6), pp. 1494-1507. Date of Electronic Publication: 2025 Nov 21.
Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase II; Clinical Trial, Phase III
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0006777 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0428 (Electronic) Linking ISSN: 0012186X NLM ISO Abbreviation: Diabetologia Subsets: MEDLINE
Database: MEDLINE Ultimate
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DbLabel: MEDLINE Ultimate
An: 41272211
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Efficacy and safety of efsubaglutide alfa in individuals with type 2 diabetes (SUPER1): a randomised, double-blind, placebo-controlled, Phase IIb/III trial.
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  Data: <searchLink fieldCode="AU" term="%22Zhu+D%22">Zhu D</searchLink>; Department of Endocrinology, Nanjing Drum Tower Hospital, affiliated with Nanjing University School of Medicine, Nanjing, China. zhudalong@nju.edu.cn.<br /><searchLink fieldCode="AU" term="%22Ma+J%22">Ma J</searchLink>; Department of Endocrinology, Nanjing First Hospital, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Wang+W%22">Wang W</searchLink>; Department of Endocrinology, Nanjing Drum Tower Hospital, affiliated with Nanjing University School of Medicine, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Shi+B%22">Shi B</searchLink>; Department of Endocrinology and Metabolism, the First Affiliated Hospital of Soochow University, Suzhou, China.<br /><searchLink fieldCode="AU" term="%22Dong+X%22">Dong X</searchLink>; Department of Endocrinology and Metabolism, Jinan Central Hospital Affiliated to Shandong First Medical University, Jinan, China.<br /><searchLink fieldCode="AU" term="%22Bian+F%22">Bian F</searchLink>; Department of Endocrinology and Metabolism, Cangzhou People's Hospital, Cangzhou, China.<br /><searchLink fieldCode="AU" term="%22Li+Q%22">Li Q</searchLink>; Department of Endocrinology and Metabolism, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Endocrinology and Metabolism, Nanyang First People's Hospital, Nanyang, China.<br /><searchLink fieldCode="AU" term="%22Jiang+C%22">Jiang C</searchLink>; Department of Endocrinology and Metabolism, First People's Hospital of Zunyi, Zunyi, China.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Department of Endocrinology and Metabolism, Central Hospital of Jinzhou, Jinzhou, China.<br /><searchLink fieldCode="AU" term="%22Wang+K%22">Wang K</searchLink>; Department of Endocrinology and Metabolism, Nanjing Jiangning Hospital, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Ling+H%22">Ling H</searchLink>; 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  Data: <searchLink fieldCode="JN" term="%220006777%22">Diabetologia</searchLink> [Diabetologia] 2026 Jun; Vol. 69 (6), pp. 1494-1507. <i>Date of Electronic Publication: </i>2025 Nov 21.
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            NameFull: Liang Y
      – PersonEntity:
          Name:
            NameFull: Guo J
      – PersonEntity:
          Name:
            NameFull: Wang Y
      – PersonEntity:
          Name:
            NameFull: Li Y
      – PersonEntity:
          Name:
            NameFull: Xu N
      – PersonEntity:
          Name:
            NameFull: Zhang J
      – PersonEntity:
          Name:
            NameFull: Zhang Q
      – PersonEntity:
          Name:
            NameFull: Pang W
      – PersonEntity:
          Name:
            NameFull: Yu J
      – PersonEntity:
          Name:
            NameFull: Xu Y
      – PersonEntity:
          Name:
            NameFull: Zhou Y
      – PersonEntity:
          Name:
            NameFull: Li Y
      – PersonEntity:
          Name:
            NameFull: Wang Q
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 06
              Text: 2026 Jun
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1432-0428
          Numbering:
            – Type: volume
              Value: 69
            – Type: issue
              Value: 6
          Titles:
            – TitleFull: Diabetologia
              Type: main
ResultId 1