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A comprehensive computational and experimental study of novel imidazole linked thiadiazole based amide derivatives as cholinesterase duel-target inhibitor for the treatment of Alzheimer's disease.

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Title: A comprehensive computational and experimental study of novel imidazole linked thiadiazole based amide derivatives as cholinesterase duel-target inhibitor for the treatment of Alzheimer's disease.
Authors: Khan Y; Department of Chemistry, COMSATS University Islamabad, Islamabad 45550, Pakistan. Electronic address: yousaf7n@gmail.com., Naeem MU; Life Sciences Department, Abasyn University, Islamabad, Pakistan. Electronic address: mujeebulnaeem@gmail.com., Arooj K; Department of Pharmaceutical Sciences, Southwest University, Chongqing, China. Electronic address: Komalaroojfatima@gmail.com., Naseem M; Department of Zoology, University of Balochistan, Quetta, Pakistan. Electronic address: mahrukhnaseem@rocketmail.com., Adnan R; Department of Computer Science, COMSATS University Islamabad, Islamabad 45550, Pakistan. Electronic address: rubina_adnan@comsats.edu.pk., Azmatullah; Department of Zoology, Quaid-e-Azam University Islamabad, Pakistan. Electronic address: azmat6520@gmail.com.
Source: Computational biology and chemistry [Comput Biol Chem] 2026 Feb; Vol. 120 (Pt 1), pp. 108789. Date of Electronic Publication: 2025 Nov 17.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 101157394 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-928X (Electronic) Linking ISSN: 14769271 NLM ISO Abbreviation: Comput Biol Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A comprehensive computational and experimental study of novel imidazole linked thiadiazole based amide derivatives as cholinesterase duel-target inhibitor for the treatment of Alzheimer's disease.
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  Data: <searchLink fieldCode="AU" term="%22Khan+Y%22">Khan Y</searchLink>; Department of Chemistry, COMSATS University Islamabad, Islamabad 45550, Pakistan. Electronic address: yousaf7n@gmail.com.<br /><searchLink fieldCode="AU" term="%22Naeem+MU%22">Naeem MU</searchLink>; Life Sciences Department, Abasyn University, Islamabad, Pakistan. Electronic address: mujeebulnaeem@gmail.com.<br /><searchLink fieldCode="AU" term="%22Arooj+K%22">Arooj K</searchLink>; Department of Pharmaceutical Sciences, Southwest University, Chongqing, China. Electronic address: Komalaroojfatima@gmail.com.<br /><searchLink fieldCode="AU" term="%22Naseem+M%22">Naseem M</searchLink>; Department of Zoology, University of Balochistan, Quetta, Pakistan. Electronic address: mahrukhnaseem@rocketmail.com.<br /><searchLink fieldCode="AU" term="%22Adnan+R%22">Adnan R</searchLink>; Department of Computer Science, COMSATS University Islamabad, Islamabad 45550, Pakistan. Electronic address: rubina_adnan@comsats.edu.pk.<br /><searchLink fieldCode="AU" term="%22Azmatullah%22">Azmatullah</searchLink>; Department of Zoology, Quaid-e-Azam University Islamabad, Pakistan. Electronic address: azmat6520@gmail.com.
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  Data: <searchLink fieldCode="JN" term="%22101157394%22">Computational biology and chemistry</searchLink> [Comput Biol Chem] 2026 Feb; Vol. 120 (Pt 1), pp. 108789. <i>Date of Electronic Publication: </i>2025 Nov 17.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101157394 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1476-928X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214769271%22">14769271 </searchLink><i>NLM ISO Abbreviation: </i>Comput Biol Chem <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.compbiolchem.2025.108789
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        Text: English
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      – TitleFull: A comprehensive computational and experimental study of novel imidazole linked thiadiazole based amide derivatives as cholinesterase duel-target inhibitor for the treatment of Alzheimer's disease.
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              Text: 2026 Feb
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              Value: 120
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