Allosteric regulation of BH3-in-groove interactions by tail anchors of BCL-xL complexes limits BH3 mimetic antagonism.
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| Title: | Allosteric regulation of BH3-in-groove interactions by tail anchors of BCL-xL complexes limits BH3 mimetic antagonism. |
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| Authors: | Maillet L; INSERM, CNRS, CRCI2NA, U1307, UMR6075, Nantes Université, Nantes, France. laurent.maillet@inserm.fr.; Equipe Labellisée LIGUE Contre le Cancer, Paris, France. laurent.maillet@inserm.fr.; SIRIC ILIAD, Nantes, Angers, France. laurent.maillet@inserm.fr., Fétiveau A; INSERM, CNRS, CRCI2NA, U1307, UMR6075, Nantes Université, Nantes, France.; Equipe Labellisée LIGUE Contre le Cancer, Paris, France.; SIRIC ILIAD, Nantes, Angers, France., Lalier L; INSERM, CNRS, CRCI2NA, U1307, UMR6075, Nantes Université, Nantes, France.; Equipe Labellisée LIGUE Contre le Cancer, Paris, France.; SIRIC ILIAD, Nantes, Angers, France.; Institut de Cancérologie de l'Ouest, Saint Herblain, France., Martin N; INSERM, CNRS, CRCI2NA, U1307, UMR6075, Nantes Université, Nantes, France.; Equipe Labellisée LIGUE Contre le Cancer, Paris, France.; SIRIC ILIAD, Nantes, Angers, France., Barillé-Nion S; INSERM, CNRS, CRCI2NA, U1307, UMR6075, Nantes Université, Nantes, France.; Equipe Labellisée LIGUE Contre le Cancer, Paris, France.; SIRIC ILIAD, Nantes, Angers, France., Guette C; INSERM, CNRS, CRCI2NA, U1307, UMR6075, Nantes Université, Nantes, France.; Equipe Labellisée LIGUE Contre le Cancer, Paris, France.; SIRIC ILIAD, Nantes, Angers, France.; Institut de Cancérologie de l'Ouest, Angers, France., Gautier F; INSERM, CNRS, CRCI2NA, U1307, UMR6075, Nantes Université, Nantes, France.; Equipe Labellisée LIGUE Contre le Cancer, Paris, France.; SIRIC ILIAD, Nantes, Angers, France.; Institut de Cancérologie de l'Ouest, Angers, France., Téletchéa S; CNRS, US2B, UMR 6286, Nantes Université, Nantes, France., Juin PP; INSERM, CNRS, CRCI2NA, U1307, UMR6075, Nantes Université, Nantes, France. philippe.juin@univ-nantes.fr.; Equipe Labellisée LIGUE Contre le Cancer, Paris, France. philippe.juin@univ-nantes.fr.; SIRIC ILIAD, Nantes, Angers, France. philippe.juin@univ-nantes.fr.; Institut de Cancérologie de l'Ouest, Saint Herblain, France. philippe.juin@univ-nantes.fr. |
| Source: | Nature communications [Nat Commun] 2025 Nov 22; Vol. 16 (1), pp. 10621. Date of Electronic Publication: 2025 Nov 22. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41274891 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Allosteric regulation of BH3-in-groove interactions by tail anchors of BCL-xL complexes limits BH3 mimetic antagonism. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Maillet+L%22">Maillet L</searchLink>; INSERM, CNRS, CRCI2NA, U1307, UMR6075, Nantes Université, Nantes, France. laurent.maillet@inserm.fr.; Equipe Labellisée LIGUE Contre le Cancer, Paris, France. laurent.maillet@inserm.fr.; SIRIC ILIAD, Nantes, Angers, France. laurent.maillet@inserm.fr.<br /><searchLink fieldCode="AU" term="%22Fétiveau+A%22">Fétiveau A</searchLink>; INSERM, CNRS, CRCI2NA, U1307, UMR6075, Nantes Université, Nantes, France.; Equipe Labellisée LIGUE Contre le Cancer, Paris, France.; SIRIC ILIAD, Nantes, Angers, France.<br /><searchLink fieldCode="AU" term="%22Lalier+L%22">Lalier L</searchLink>; INSERM, CNRS, CRCI2NA, U1307, UMR6075, Nantes Université, Nantes, France.; Equipe Labellisée LIGUE Contre le Cancer, Paris, France.; SIRIC ILIAD, Nantes, Angers, France.; Institut de Cancérologie de l'Ouest, Saint Herblain, France.<br /><searchLink fieldCode="AU" term="%22Martin+N%22">Martin N</searchLink>; INSERM, CNRS, CRCI2NA, U1307, UMR6075, Nantes Université, Nantes, France.; Equipe Labellisée LIGUE Contre le Cancer, Paris, France.; SIRIC ILIAD, Nantes, Angers, France.<br /><searchLink fieldCode="AU" term="%22Barillé-Nion+S%22">Barillé-Nion S</searchLink>; INSERM, CNRS, CRCI2NA, U1307, UMR6075, Nantes Université, Nantes, France.; Equipe Labellisée LIGUE Contre le Cancer, Paris, France.; SIRIC ILIAD, Nantes, Angers, France.<br /><searchLink fieldCode="AU" term="%22Guette+C%22">Guette C</searchLink>; INSERM, CNRS, CRCI2NA, U1307, UMR6075, Nantes Université, Nantes, France.; Equipe Labellisée LIGUE Contre le Cancer, Paris, France.; SIRIC ILIAD, Nantes, Angers, France.; Institut de Cancérologie de l'Ouest, Angers, France.<br /><searchLink fieldCode="AU" term="%22Gautier+F%22">Gautier F</searchLink>; INSERM, CNRS, CRCI2NA, U1307, UMR6075, Nantes Université, Nantes, France.; Equipe Labellisée LIGUE Contre le Cancer, Paris, France.; SIRIC ILIAD, Nantes, Angers, France.; Institut de Cancérologie de l'Ouest, Angers, France.<br /><searchLink fieldCode="AU" term="%22Téletchéa+S%22">Téletchéa S</searchLink>; CNRS, US2B, UMR 6286, Nantes Université, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Juin+PP%22">Juin PP</searchLink>; INSERM, CNRS, CRCI2NA, U1307, UMR6075, Nantes Université, Nantes, France. philippe.juin@univ-nantes.fr.; Equipe Labellisée LIGUE Contre le Cancer, Paris, France. philippe.juin@univ-nantes.fr.; SIRIC ILIAD, Nantes, Angers, France. philippe.juin@univ-nantes.fr.; Institut de Cancérologie de l'Ouest, Saint Herblain, France. philippe.juin@univ-nantes.fr. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2025 Nov 22; Vol. 16 (1), pp. 10621. <i>Date of Electronic Publication: </i>2025 Nov 22. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101528555 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-1723 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220411723%22">20411723 </searchLink><i>NLM ISO Abbreviation: </i>Nat Commun <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41274891 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41467-025-65509-1 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 10621 Titles: – TitleFull: Allosteric regulation of BH3-in-groove interactions by tail anchors of BCL-xL complexes limits BH3 mimetic antagonism. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Maillet L – PersonEntity: Name: NameFull: Fétiveau A – PersonEntity: Name: NameFull: Lalier L – PersonEntity: Name: NameFull: Martin N – PersonEntity: Name: NameFull: Barillé-Nion S – PersonEntity: Name: NameFull: Guette C – PersonEntity: Name: NameFull: Gautier F – PersonEntity: Name: NameFull: Téletchéa S – PersonEntity: Name: NameFull: Juin PP IsPartOfRelationships: – BibEntity: Dates: – D: 22 M: 11 Text: 2025 Nov 22 Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 2041-1723 Numbering: – Type: volume Value: 16 – Type: issue Value: 1 Titles: – TitleFull: Nature communications Type: main |
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