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Imputation of untreated LDL-C in treated subjects with homozygous familial hypercholesterolaemia: An international collaboration.

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Title: Imputation of untreated LDL-C in treated subjects with homozygous familial hypercholesterolaemia: An international collaboration.
Authors: John Mancini GB; Centre for Cardiovascular Innovation, Dilawri Cardiovascular Institute, Division of Cardiology, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address: mancini@mail.ubc.ca., Ryomoto A; Centre for Cardiovascular Innovation, Dilawri Cardiovascular Institute, Division of Cardiology, University of British Columbia, Vancouver, British Columbia, Canada., Ruel I; Research Institute of the McGill University Health Center, Department of Medicine, Montreal, Quebec, Canada., Iatan I; Research Institute of the McGill University Health Center, Department of Medicine, Montreal, Quebec, Canada; Centre for Heart and Lung Innovation, Division of General Internal Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Raal FJ; Department of Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Santos RD; Academic Research Organization, Hospital Israelita Albert Einstein, Sao Paulo, Brazil; Lipid Clinic, Heart Institute (InCor) University of Sao Paulo, Medical School Hospital, Sao Paulo, Brazil., Marte AP; Lipid Clinic, Heart Institute (InCor) University of Sao Paulo, Medical School Hospital, Sao Paulo, Brazil., Hegele RA; Departments of Medicine and Biochemistry, Robarts Research Institute, University of Western Ontario, London, Ontario, Canada., Kennedy BA; Departments of Medicine and Biochemistry, Robarts Research Institute, University of Western Ontario, London, Ontario, Canada., Brunham LR; Centre for Heart and Lung Innovation, Division of General Internal Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Gaudet D; Department of Medicine and ECOGENE-21, University of Montreal, Chicoutimi, Quebec, Canada., Larouche M; Department of Medicine and ECOGENE-21, University of Montreal, Chicoutimi, Quebec, Canada., Brisson D; Department of Medicine and ECOGENE-21, University of Montreal, Chicoutimi, Quebec, Canada., Schonck W; Department of Vascular Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, Amsterdam, the Netherlands., Reeskamp LF; Department of Vascular Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, Amsterdam, the Netherlands., Genest J; Research Institute of the McGill University Health Center, Department of Medicine, Montreal, Quebec, Canada.
Corporate Authors: Canadian Homozygous Familial Hypercholesterolemia Registry and the Homozygous Familial Hypercholesterolemia International Clinical Collaboration
Source: Atherosclerosis [Atherosclerosis] 2026 Jan; Vol. 412, pp. 120590. Date of Electronic Publication: 2025 Nov 19.
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: Elsevier Country of Publication: Ireland NLM ID: 0242543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1484 (Electronic) Linking ISSN: 00219150 NLM ISO Abbreviation: Atherosclerosis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22John+Mancini+GB%22">John Mancini GB</searchLink>; Centre for Cardiovascular Innovation, Dilawri Cardiovascular Institute, Division of Cardiology, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address: mancini@mail.ubc.ca.<br /><searchLink fieldCode="AU" term="%22Ryomoto+A%22">Ryomoto A</searchLink>; Centre for Cardiovascular Innovation, Dilawri Cardiovascular Institute, Division of Cardiology, University of British Columbia, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Ruel+I%22">Ruel I</searchLink>; Research Institute of the McGill University Health Center, Department of Medicine, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Iatan+I%22">Iatan I</searchLink>; Research Institute of the McGill University Health Center, Department of Medicine, Montreal, Quebec, Canada; Centre for Heart and Lung Innovation, Division of General Internal Medicine, University of British Columbia, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Raal+FJ%22">Raal FJ</searchLink>; Department of Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.<br /><searchLink fieldCode="AU" term="%22Santos+RD%22">Santos RD</searchLink>; Academic Research Organization, Hospital Israelita Albert Einstein, Sao Paulo, Brazil; Lipid Clinic, Heart Institute (InCor) University of Sao Paulo, Medical School Hospital, Sao Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Marte+AP%22">Marte AP</searchLink>; Lipid Clinic, Heart Institute (InCor) University of Sao Paulo, Medical School Hospital, Sao Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Hegele+RA%22">Hegele RA</searchLink>; Departments of Medicine and Biochemistry, Robarts Research Institute, University of Western Ontario, London, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Kennedy+BA%22">Kennedy BA</searchLink>; Departments of Medicine and Biochemistry, Robarts Research Institute, University of Western Ontario, London, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Brunham+LR%22">Brunham LR</searchLink>; Centre for Heart and Lung Innovation, Division of General Internal Medicine, University of British Columbia, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Gaudet+D%22">Gaudet D</searchLink>; Department of Medicine and ECOGENE-21, University of Montreal, Chicoutimi, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Larouche+M%22">Larouche M</searchLink>; Department of Medicine and ECOGENE-21, University of Montreal, Chicoutimi, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Brisson+D%22">Brisson D</searchLink>; Department of Medicine and ECOGENE-21, University of Montreal, Chicoutimi, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Schonck+W%22">Schonck W</searchLink>; Department of Vascular Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Reeskamp+LF%22">Reeskamp LF</searchLink>; Department of Vascular Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Genest+J%22">Genest J</searchLink>; Research Institute of the McGill University Health Center, Department of Medicine, Montreal, Quebec, Canada.
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  Data: <searchLink fieldCode="JN" term="%220242543%22">Atherosclerosis</searchLink> [Atherosclerosis] 2026 Jan; Vol. 412, pp. 120590. <i>Date of Electronic Publication: </i>2025 Nov 19.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>Ireland <i>NLM ID: </i>0242543 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1879-1484 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200219150%22">00219150 </searchLink><i>NLM ISO Abbreviation: </i>Atherosclerosis <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.atherosclerosis.2025.120590
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        Text: English
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              Text: 2026 Jan
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